Ficha Cuerpo Académico
Esp
Bioenergetics and cell aging
Discipline Health Sciences
Academic Group Consolidated
Year of registration: 2014
Members
| Name | Lines of research |
| Dr. Adriana Alarcón Aguilar. | 1, 2, 3, 4, 6. |
| Dr. Laura Josefina Pérez Flores. | 4, 6. |
| Dr. Mina Konigsberg Fainstein. Leader of GA | 1, 2, 3, 4, 5, 6. |
| Dr. Norma Edith López Díaz Guerrero. | 1, 2, 3, 4, 5, 6. |
Knowledge Generation and Application Lines
1.- Aging and oxidative stress.
2.- Cellular senescence.
3.- Mitochondrial bioenergetics.
4.- Hormetic mechanisms.
5.- Oxidative stress.
6.- Evaluation of bioactive compounds.
Description
1.- One of the most accepted theories to explain aging is the one proposed by Harman in 1956, where he suggests that aging is caused by the accumulation of unrepaired oxidative damage in biomolecules. Therefore, in order to understand the participation of oxidative stress during aging, it is proposed to study oxidative damage in the main biomolecules: lipids, DNA and proteins. Along with the levels and activity of various antioxidant enzymes, as well as the redox state in various study models and different experimental conditions.
2.- It has been reported that the accumulation of ...
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1.- One of the most accepted theories to explain aging is the one proposed by Harman in 1956, where he suggests that aging is caused by the accumulation of unrepaired oxidative damage in biomolecules. Therefore, in order to understand the participation of oxidative stress during aging, it is proposed to study oxidative damage in the main biomolecules: lipids, DNA and proteins. Along with the levels and activity of various antioxidant enzymes, as well as the redox state in various study models and different experimental conditions.
2.- It has been reported that the accumulation of senescent cells is a phenomenon that contributes to deterioration during aging, so it is important to study the different pathways of induction of senescence (replicative senescence, stress-induced senescence, senescence induced by loss of proteostasis, etc) as well as its dependence on changes in the redox state and oxidative stress and particularly the secretion of cytokines and various factors known as SASP (Senescence-associated secretory phenotype).
3.- The mitochondrion has been highlighted as a source and target of reactive oxygen species, in addition to the loss of bioenergetic activity and alterations in mitochondrial dynamics (fusion and fission processes) have been related to aging and diseases of the elderly. Therefore, it is also of interest to understand the changes in bioenergetic metabolism (respiratory/glycolytic) and mitochondrial dynamics during senescence and aging in different experimental conditions.
4.- Hormesis can be defined as "the process by which exposure to a low dose of a chemical agent or environmental factor, which is harmful at high doses, induces an adaptive response and/or a beneficial effect in the cell or organism". Therefore, it has been pointed out that hormesis, mainly related to oxidative stress and inflammation, could contribute to successful aging and increased longevity. Therefore, it is relevant to study the hormetic mechanisms during aging and senescence in different models and under different experimental conditions.
5.- Oxidative damage is not only related to aging but also to a large number of diseases (such as cancer, neurodegenerative diseases, etc.) and to physiological alterations in general. Therefore, another field of interest of our AC is the study of oxidative stress in different models, as well as the implementation of different techniques that allow its evaluation.
6.- In recent years it has been reported that there are a large number of compounds of plant origin that have an important biological activity, so they have been called bioactive compounds (BAC). Among the functions that have been attributed to the CBA are those of being anti-inflammatory, anti-proliferative, anti-cancerous, etc. Therefore, our interest is to isolate certain CBA from different vegetables and test if they have antioxidant effect or if they delay the entry of cells to cellular senescence. It would also be interesting to evaluate whether CBA can modify the secretion of cytokines and chemokines produced by senescent cells, which together are known as SASP (senescence-associated secretory phenotype). It has been reported that SASP can have deleterious effects on neighboring cells, promoting the establishment of diseases such as cancer, neurodegenerative diseases and aging-associated deterioration.
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