Academic Work

• ORCID
• Google scholar
• Scopus

Sustainable Development Goals

Research interests

• Systemic lupus erythematosus
• Asymptomatic hyperuricemia
• Autoimmunity
• Inflammation
• COVID-19

Profile

Professor Luis Manuel Amezcua Guerra did his undergraduate degree in General Medicine at the Faculty of Medicine of the Universidad Nacional Autónoma de México (UNAM) within the Program of High Academic Demand (PAEA) or Educational Quality Nuclei (NUCE). He completed an undergraduate medical internship at the National Institute of Medical Sciences and Nutrition Salvador Zubirán (INCMNSZ).

He did a Specialty in Internal Medicine at the Hospital Regional 1 de Octubre of the Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE). Chief Resident of Internal Medicine. Subspecialty in Rheumatology at the Instituto Nacional de Cardiología Ignacio Chávez (INCICh). Chief Resident of Rheumatology.

Ph.D. in Biological and Health Sciences at the Universidad Autónoma Metropolitana (UAM) and received the University Merit Medal.

He is a Researcher in Medical Sciences at the Department of Immunology of the Instituto Nacional de Cardiología Ignacio Chávez (INCICh) and Coordinator of the Unidad de Investigación en Medicina Traslacional UNAM-INCICh. Head of the Department of Immunology of the Instituto Nacional de Cardiología Ignacio Chávez (INCICh).

Professor and Researcher of the Health Care Department of the Universidad Autónoma Metropolitana (UAM) Xochimilco Campus.

Member of the Mexican Council of Rheumatology (CMR). Member Level II of the National System of Researchers of the National Council of Science and Technology (CONACYT).

Information provided by the academic staff

Research interests

• Systemic lupus erythematosus
• Asymptomatic hyperuricemia
• Autoimmunity
• Inflammation
• COVID-19

Academic Work

On the following pages you can consult the research work:

• Google scholar

See publications

• Scopus

See publications

• ORCID

See publications

Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
OA	Amezcua-Guerra, L.M., Soberanes-García, M.G., Barragán-Huerta, L. and 11 more (...) (2026).Serum from Antiphospholipid Syndrome Patients Downregulates Endothelial lncRNAs HIF1A-AS1 and OIP5-AS1. International Journal of Molecular Sciences,27(10)
OA	Chan-Delgado, E., Lerma, C., Echeverría, J.C. and 8 more (...) (2026).Matrix metalloproteinase activation and TNF upregulation characterize the sclerotic phase of aortic valve disease. British journal of biomedical science,83	\| 3 \|
	Paulino-Gonzalez, D., Pardiño-Vega, M.A., Andrade-Arbaiza, E. and 5 more (...) (2026).SGLT-2 Inhibitors After Acute Coronary Syndrome As Preventive Approach for Heart Failure-Related Complications: A Meta-Analysis. American journal of therapeutics,33(3) e236-e247	\| 3 \|
OA	Espinosa-Bautista, F., Soberanes-García, M.G., Castillo-Martínez, D. and 3 more (...) (2026).Altered extracellular matrix remodeling accompanies decreased lncRNA HOTAIR expression in Takayasu arteritis. Frontiers in immunology,17
	Amezcua-Guerra, L.M., Brianza-Padilla, M., Martínez-García, M. and 1 more (...) (2026).Establishment of High-Altitude Reference Values for the Pan-Immune-Inflammation Value in Healthy Adults Living in Mexico City. Archives of Medical Research,57(1)
	García-García, A.J., Ruiz-Vásquez, U., Suárez-Aguilar, C. and 11 more (...) (2026).Impact of the American Heart Association/American College of Cardiology Blood Pressure Classification on Insulin Resistance. Archives of Medical Research,57(6)
OA	Soberanes-García, M.G., Barragán-Huerta, L., Brianza-Padilla, M. and 3 more (...) (2025).Serum levels of metalloproteinases as predictive biomarkers of adverse cardiovascular events in male patients with ST-segment elevation myocardial infarction. Archivos de Cardiologia de Mexico,95(3) 250-254	\| 3 \|
	Amezcua-Guerra, L.M., Roldán-Ortega, J., Mora-Ramírez, M. (2025).Rhupus syndrome: current knowledge and future perspectives. Expert Review of Clinical Immunology,21(12) 1709-1724
OA	Amezcua-Castillo, E., Amezcua-Castillo, L.M., Barragán-Huerta, L. and 2 more (...) (2025).Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach. Medical Hypotheses,201
	Amezcua-Guerra, B., Amezcua-Castillo, L.M., Guerra-López, J.A. and 3 more (...) (2025).Cytokine-Based Validation of the Inflammation-Based Risk Score in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Interferon and Cytokine Research,45(3) 91-98
OA	Espinosa-Bautista, F., Ramos-Rosillo, V., Vazquez-Panchos, Y. and 4 more (...) (2025).Insights into the clinical and immunological significance of anti-α-fodrin antibodies in systemic lupus erythematosus. Rheumatology and Immunology Research,6(1) 59-62
OA	Morales-Rentería, A., Ruiz-Santos, A., Amezcua-Castillo, L.M. and 5 more (...) (2025).MIR-155 as a potential biomarker for disease severity in st-segment elevation myocardial infarction: insights from a university-affiliated cardiovascular center. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,77(1) 013-025	\| 3 \|
OA	Espinosa-Bautista, F., Ramos-Rosillo, V., Vazquez-Panchos, Y. and 6 more (...) (2025).Influence of menopause status on T-helper cell profiles in acute myocardial infarction. Biomolecules and Biomedicine,25(11) 2513-2518
OA	Guzmán-Martín, C.A., Jiménez-Ortega, R.F., Ortega-Springall, M.F. and 6 more (...) (2025).miR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers. Scientific Reports,15(1)
OA	Martínez-Nava, G.A., Altamirano-Molina, E., Vázquez-Mellado, J. and 24 more (...) (2025).Metatranscriptomic analysis reveals gut microbiome bacterial genes in pyruvate and amino acid metabolism associated with hyperuricemia and gout in humans. Scientific Reports,15(1)
	Miranda-Mendoza, H., Paulino-González, D., Sesma-Soto, J. and 9 more (...) (2025).Establishing reference values for serum urate in healthy adults from Mexico City: Data from the Tlalpan 2020 cohort. Reumatologia Clinica,21(8)
OA	Peña-Peña, M., Bermúdez-Benítez, E., Sánchez-Gloria, J.L. and 12 more (...) (2025).A 14-Day Plant-Based Dietary Intervention Modulates the Plasma Levels of Rheumatoid Arthritis-Associated MicroRNAs: A Bioinformatics-Guided Pilot Study. Nutrients ,17(13)
	Guzmán-García, S., Sacoto-Flores, G., Román-Bermeo, J. and 5 more (...) (2025).Risk predictors for adverse COVID-19 outcomes in Latin American patients with autoimmune rheumatic diseases: A multicentre study in Ecuador and Mexico. Revista Colombiana de Reumatologia,32(2) 152-158	\| 3 \|
OA	Amezcua-Guerra, L.M., Velázquez-Espinosa, K.P., Piña-Soto, L.A. and 3 more (...) (2024).The Self-Reported Quality of Sleep and Its Relationship with the Development of Arterial Hypertension: Perspectives from the Tlalpan 2020 Cohort. Journal of Clinical Medicine,13(20)
OA	Sáenz-San Martín, A., Méndez-Ocampo, P., Gutiérrez-Moctezuma, I. and 1 more (...) (2024).C-reactive protein, cardiovascular issues of an acute-phase protein: an update for the clinician. Archivos de Cardiologia de Mexico,94(2) 191-202	\| 3 \|
	Castillo-Martínez, D., Mora-Ramírez, M., Molina-Sánchez, R. and 1 more (...) (2024).The 2023 ACR/EULAR antiphospholipid syndrome classification criteria identify patients at high risk of complications. Clinical Rheumatology,43(11) 3373-3377
OA	Cruz-Gregorio, A., Amezcua-Guerra, L.M., Fisher-Bautista, B. and 2 more (...) (2024).The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation. International Journal of Molecular Sciences,25(18)	\| 3 \|
OA	Amezcua-Guerra, L.M., Pazarán-Romero, G., Gutiérrez-Esparza, G.O. and 4 more (...) (2024).Gender assessment of sleep disorders in an adult urban population of Mexico City. Salud Publica de Mexico,66(6) 824-830	\| 10 \|
	Espinosa-Bautista, F., Salazar-Sánchez, M.I., Brianza-Padilla, M. and 5 more (...) (2024).Dysregulation of long non-coding RNAs in Takayasu arteritis: A proof-of-concept study. Clinical Rheumatology,43(3) 1253-1259	\| 3 \|
	Bocanegra-Zamora, F., Espinosa-Bautista, F., Jiménez-Rodríguez, G.M. and 6 more (...) (2024).Senescent CD4+ T-Cell Phenotypes and Inflammatory Milieu in the Coronary and Systemic Circulation in ST-Elevation Myocardial Infarction: An Exploratory Study. Journal of Vascular Research,61(5) 260-266	\| 3 \|
	Hernández-Solano, L., Amezcua-Castillo, E., Amezcua-Guerra, L.M. (2023).Dyslipidemia is not associated with interferon-regulated chemokines or disease activity in systemic lupus erythematosus. Clinical Rheumatology,42(7) 1993-1995
	Springall, R., Ortega-Springall, M.F., Guerrero-Ponce, A.E. and 2 more (...) (2023).Interleukin-17 and Tumor Necrosis Factor Show a Functional Hierarchy to Regulate the Production of Matrix Metalloproteases by Monocytes from Patients with Psoriasis. Journal of Interferon and Cytokine Research,43(3) 140-146
OA	Amezcua-Guerra, L.M., Sánchez-Muñoz, F., Guzmán-García, S. and 4 more (...) (2023).Mononuclear cells from patients with rhupus are influenced by TNF in their production of gp130/sIL-6Rb and APRIL. Lupus Science and Medicine,10(2)	\| 3 \|
OA	Amezcua-Castillo, E., González-Pacheco, H., Sáenz-San Martín, A. and 8 more (...) (2023).C-Reactive Protein: The Quintessential Marker of Systemic Inflammation in Coronary Artery Disease—Advancing toward Precision Medicine. Biomedicines,11(9)	\| 3 \|
OA	Díaz-Domínguez, K.A., Cruz-Melendez, A., Amezcua-Castillo, L.M. and 4 more (...) (2023).Should a recent SARS-CoV-2 infection be considered a risk or prognostic factor for ST-segment elevation myocardial infarction?. Archivos de Cardiologia de Mexico,9316-21	\| 3 \|
	Guzmán-Martín, C.A., Juárez-Vicuña, Y., Domínguez-López, A. and 4 more (...) (2023).lncRNAs dysregulation in monocytes from primary antiphospholipid syndrome patients: a bioinformatic and an experimental proof-of-concept approach. Molecular Biology Reports,50(1) 937-941
	Amezcua-Guerra, L.M., Carbonell-Bobadilla, N., Soto-Fajardo, C. and 8 more (...) (2023).Influence of anti-carbamylated protein antibodies on disease activity and joint erosions in seronegative and seropositive rheumatoid arthritis. Rheumatology International,43(12) 2245-2250
OA	Bojalil, R., Ruíz-Hernández, A., Villanueva-Arias, A. and 9 more (...) (2023).Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia. Biological Research,56(1)
	Amezcua-Guerra, L.M., Espinosa-Bautista, F., Hopf-Estandía, K. and 12 more (...) (2023).Senescent CD4+CD28null cells are increased in chronic hyperuricemia, show aberrant effector phenotypes, and are reversed after allopurinol therapy: a proof-of-concept pilot study. Clinical Rheumatology,42(8) 2181-2186
OA	Amezcua-Guerra, B., Amezcua-Castillo, L.M., Guerra-López, J.A. and 17 more (...) (2023).Diagnostic Performance of Serum MicroRNAs for ST-Segment Elevation Myocardial Infarction in the Emergency Department. Biomedicines,11(9)	\| 3 \|
OA	Amezcua-Guerra, L.M., Guzmán-Martín, C.A., Montúfar-Robles, I. and 5 more (...) (2023).CD147 rs8259T>A Variant Confers Susceptibility to COVID-19 Infection within the Mexican Population. Microorganisms,11(8)	\| 3 \|
OA	Amezcua-Guerra, L.M., Sánchez-Muñoz, F., Pichardo-Ontiveros, E. and 3 more (...) (2022).Interferon-alpha regulates expression of lncRNA MALAT1 and interferon-stimulated genes, as well as chemokine production, in primary Sjögren’s syndrome. Clinical and Experimental Rheumatology,40(12) 2275-2282
	Guerra-López, J.A., Amezcua-Castillo, L.M., González-Pacheco, H. and 1 more (...) (2022).Levels of Vascular Endothelial Growth Factor and Its Association with Pulmonary Embolism in COVID-19. Journal of Interferon and Cytokine Research,42(8) 444-448	\| 3 \|
	Espinosa-Bautista, F., Coronel, D., Ramos-Rosillo, V. and 1 more (...) (2022).Performance analysis of Luminex and ELISA to profile serum IP-10 as a biomarker in systemic lupus erythematosus. Lupus,31(13) 1660-1665
OA	Amezcua-Guerra, L.M., Mora-Ramirez, M., Vancini, G. and 2 more (...) (2022).Fibroblast Growth Factor 23 Levels in Pulmonary Involvement Associated With Systemic Sclerosis: A Proof-of-concept Study. Journal of Rheumatology,49(5) 542-544
	Brianza-Padilla, M., Juárez-Vicuña, Y., Springall, R. and 3 more (...) (2022).Antinuclear antibodies detected by Enzyme-Linked Immunosorbent Assay (ELISA) in severe COVID-19: Clinical and laboratory associations. European Review for Medical and Pharmacological Sciences,26(14) 5307-5310	\| 3 \|
OA	Hernández-Díazcouder, A., González-Ramírez, J., Sanchez, F. and 4 more (...) (2022).Negative Effects of Chronic High Intake of Fructose on Lung Diseases. Nutrients,14(19)	\| 3 \|
OA	Carbonell-Bobadilla, N., Soto-Fajardo, C., Amezcua-Guerra, L.M. and 7 more (...) (2022).Patients with seronegative rheumatoid arthritis have a different phenotype than seropositive patients: A clinical and ultrasound study. Frontiers in Medicine,9
OA	Springall, R., González-Flores, J., García-Ávila, C. and 14 more (...) (2022).Elevated Levels of Soluble CD147 are Associated with Hyperinflammation and Disease Severity in COVID-19: A Proof-of-Concept Clinical Study. Archivum Immunologiae et Therapiae Experimentalis,70(1)	\| 3 \|
OA	González-Flores, J., García-ávila, C., Springall, R. and 16 more (...) (2021).Usefulness of easy-to-use risk scoring systems rated in the emergency department to predict major adverse outcomes in hospitalized covid-19 patients. Journal of Clinical Medicine,10(16)	\| 3 \|
	Mora-Ramírez, M., Amezcua-Guerra, L.M. (2021).The role of type III interferons in systemic autoimmune diseases. Translational Autoimmunity: Etiology of Autoimmune Diseases,199-212
	Patlán, M., Páez, A., Massó, F. and 1 more (...) (2021).Relative increase of Th17 phenotype in senescent CD4+CD28null T cells from peripheral blood of patients with rheumatoid arthritis. Clinical and Experimental Rheumatology,39(4) 925-926
OA	Castillo-Martínez, D., Torres, Z., Amezcua-Guerra, L.M. and 1 more (...) (2021).Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?. Clinical Rheumatology,40(7) 3015-3019	\| 3 \|
	Juárez-Vicuña, Y., Guzmán-Martín, C.A., Martínez-Martínez, L.A. and 7 more (...) (2021).miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome. Rheumatology International,41(7) 1329-1335
OA	Juárez-Vicuña, Y., Pérez-Ramos, J., Adalid-Peralta, L. and 8 more (...) (2021).Interferon Lambda 3/4 (IFNλ3/4) rs12979860 Polymorphisms Is Not Associated With Susceptibility to Systemic Lupus Erythematosus, Although It Regulates OASL Expression in Patients With SLE. Frontiers in Genetics,12
OA	Amezcua-Guerra, L.M., Audelo, K., Guzmán, J. and 8 more (...) (2021).A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19. Inflammation Research,70(6) 731-742	\| 3 \|
	Juárez-Vicuña, Y., Pérez-Ramos, J., Adalid-Peralta, L. and 9 more (...) (2020).The presence of IFL3/4 rs12979860 C allele influences the in vitro IP-10 production by mononuclear cells from patients with systemic lupus erythematosus. Lupus,29(5) 482-489
OA	Marquez-Velasco, R., Vallejo, M., Catrip-Torres, J.M. and 6 more (...) (2020).RESECTION OF THE ATRIAL APPENDAGES AND ITS IMPACT IN THE NATRIURETIC HOMEOSTASIS: DEVELOPMENT AND VALIDATION OF AN ANIMAL MODEL IN AN ACADEMIC MEDICAL CENTER. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,72(2) 103-109
	Castillo-Martínez, D., Amezcua-Castillo, L.M., Granados, J. and 2 more (...) (2020).Is Takayasu arteritis the result of a Mycobacterium tuberculosis infection? The use of TNF inhibitors may be the proof-of-concept to demonstrate that this association is epiphenomenal. Clinical Rheumatology,39(6) 2003-2009	\| 3 \|
	Amezcua-Guerra, L.M., Ortega-Springall, M.F., Guerrero-Ponce, A.E. and 2 more (...) (2020).Interleukin-17A enhances the production of CD147/extracellular matrix metalloproteinase inducer by monocytes from patients with psoriasis. European Review for Medical and Pharmacological Sciences,24(20) 10601-10604
	Amezcua-Castillo, L.M., Juárez-Vicuña, Y., Márquez-Velasco, R. and 1 more (...) (2020).Activation Status of NLRP3 Inflammasome in Peripheral Blood Mononuclear Cells From Patients With Gout Flare. Journal of Clinical Rheumatology,26S208-S212
	Hernández-Rodríguez, R.T., Amezcua-Guerra, L.M. (2020).The potential role of microRNAs as biomarkers in atopic dermatitis: A systematic review. European Review for Medical and Pharmacological Sciences,24(22) 11804-11809

Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	26I	Trabajo de Investigación VIII	Posgrado
2	26I	Atención Integral del Adulto I	Licenciatura
3	25O	Atención Integral del Adulto I	Licenciatura
4	25O	Atención Integral del Adulto I	Licenciatura
5	25O	Trabajo de Investigación VII	Posgrado
6	25P	Atención Integral del Adulto I	Licenciatura
7	25P	Seminario VI	Posgrado
8	25P	Trabajo de Investigación VI	Posgrado
9	25I	Atención Integral del Adulto I	Licenciatura
10	25I	Seminario V	Posgrado
11	25I	Trabajo de Investigación V	Posgrado
12	24O	Atención Integral del Adulto I	Licenciatura
13	24O	Seminario IV	Posgrado
14	24O	Trabajo de Investigación IV	Posgrado
15	24P	Atención Integral del Adulto I	Licenciatura
16	24P	Trabajo de Investigación III	Posgrado
17	24P	Seminario III	Posgrado
18	24I	Atención Integral del Adulto I	Licenciatura
19	24I	Seminario II	Posgrado
20	24I	Trabajo de Investigación II	Posgrado
21	23O	Atención Integral del Adulto I	Licenciatura
22	23O	Seminario I	Posgrado
23	23O	Trabajo de Investigación I	Posgrado
24	23P	Atención Integral del Adulto I	Licenciatura
25	23I	Atención Integral del Adulto I	Licenciatura
26	22O	Atención Integral del Adulto I	Licenciatura
27	22P	Atención Integral del Adulto I	Licenciatura
28	22I	Atención Integral del Adulto I	Licenciatura

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