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Perfil investigador
Esp
Dr. Nelly María Molina Frechero

Professor
Departament of Health Care

Division of Biological and Health Sciences


Emeritus
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Xochimilco Campus

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Sites of interest

• Web of Science

Sustainable Development Goals

• 3 Good Health and Well-being

• 6 Clean Water and Sanitation


Research interests

• Preventive dentistry
• Pathogenesis of dental fluorosis
• Genetics of oral pathologies
• Water toxicology
• Oral pathology and medicine

Profile

Doctor Nelly Molina-Frechero is a Professor working in the area of clinical sciences of the Department of Health Care; her lines of research are Preventive Dentistry, Dental Fluorosis and Caries, Water Toxicology, Basic Sciences in Dentistry, Genetics of Oral Diseases, Pathology and Oral Medicine.

She belongs to the National System of Researchers with Level III of CONACYT, is responsible for the consolidated academic group Research in Oral Health, and has a PRODEP profile.

Professor Molina participated in the creation of the Master's Degree in Dental Sciences, where she is the first Coordinator. Training of human resources: B.Sc. 48, Master's 16, and Doctorate 4.

At the undergraduate level, she has taught in the Divisional Trunk of CBS, in the career of Stomatology. At the Postgraduate level in the Doctorate in Biological and Health Sciences and Master's Degree in Dental Sciences.

In other institutions in the Master's Degree in Stomatology Sciences Universidad Juarez del Estado de Durango, Master's Degree in Pediatric Stomatology. Universidad Autónoma de Chihuahua, Master's Degree in Oral Biology. School of Dentistry UDELAR Uruguay.

Publication of more than 100 scientific articles and more than 200 specialized events at national and international level.

She participates in institutionally approved research projects and collaborates in international projects. Implemented agreements and joint works with universities at national and international level. At the national level with the Universidad Nacional Autónoma de México (UNAM), the Universidad Juárez del Estado de Durango, the Universidad de Guadalajara, the Universidad Autónoma de Chihuahua and the Universidad de San Luis Potosí, among others. Internationally with the University of Buenos Aires UBA, the University of Uruguay UDELAR and the Catholic University, the Cooperative University of Colombia and the University of Modena Italy.

The research line is integrated to the objectives of the institution in relation to sustainable development where the goals are to provide attention to vulnerable groups through actions to reduce the gaps of social and territorial inequality between different areas of the Mexican Republic and in relation to drinking water, which aims to promote and ensure access to quality and quantity of drinking water, prioritizing historically discriminated groups, ensuring the health of the population and the ecosystems and watersheds.

Evaluator of international journals such as Oral Diseases, Community Dent Oral Epidemiology, BMC Oral Health. Int J Environ Res Public Health, Med Oral Patol Oral Cir Bucal, Dis Markers, Med Sci Monit, among others. Accredited evaluator of CONACYT, PRODEP and at international level of the National Agency of Science and Technology ANII of Uruguay.



Information provided by the academic staff

Research interests

• Preventive dentistry
• Pathogenesis of dental fluorosis
• Genetics of oral pathologies
• Water toxicology
• Oral pathology and medicine

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
Lavalle-Carrasco, J., Molina-Frechero, N., López-Verdín, S. and 1 more (...) (2025).Health Implications of Proinflammatory Cytokine Activity at Different Levels of Fluoride Exposure: A Systematic Review. Journal of Applied Toxicology,45(7) 1191-1202| 3| 6 |
OALavalle-Carrasco, J., Molina-Frechero, N., Hernández-Pérez, E. and 3 more (...) (2025).Systemic fluoride levels in toenails as biomarkers of exposure and their association with the severity of dental fluorosis in Mexican schoolchildren–a cross-sectional study. Biomarkers,30(2) 140-146
OAIsiordia-Espinoza, M.A., Aragon-Martinez, O.H., Serafín-Higuera, N.A. and 6 more (...) (2025).A Quantitative Systematic Review on the Analgesic Efficacy and Adverse Effects of Ketorolac in Third Molar Surgery. Clinics and Practice,15(4)
OAMora-Falcón, I.J., Amador-Beas, I.A., Bologna-Molina, R. and 5 more (...) (2025).Analgesic Efficacy of Postoperative Ibuprofen in Third Molar Surgery: A Meta-Analysis. Oral,5(3)
OAAragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Correction to: Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review (Oral and Maxillofacial Surgery, (2025), 29, 1, (123), 10.1007/s10006-025-01416-5). Oral and Maxillofacial Surgery,29(1)
Aragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Author's Reply to the Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". Oral and Maxillofacial Surgery,29(1)
Aragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review. Oral and Maxillofacial Surgery,29(1)
OABarrón-Márquez, M.C., González-González, R., Bobadilla-Morales, L. and 5 more (...) (2025).Retracted: Cowden Syndrome and Oral Lesions: A Case Report Using MLPA. The American journal of case reports,26
OAGamarra, J., Molina-Frechero, N., Gaona, E. and 3 more (...) (2025).FLUORIDE CONCENTRATION IN DRINKING WATER SOURCES AND ASSOCIATED HEALTH RISKS. Journal of Oral Research,14424-433
OABarrón-Márquez, M.C., González-González, R., Bobadilla-Morales, L. and 5 more (...) (2025).Cowden Syndrome and Oral Lesions: A Case Report Using MLPA. American Journal of Case Reports ,26| 3 |
OASilveira, F.M., Schuch, L.F., Pereira-Prado, V. and 7 more (...) (2025).Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma. World Journal of Experimental Medicine,15(2) | 3 |
OALópez-Verdín, S., Solorzano-López, J.A., Bologna-Molina, R. and 4 more (...) (2024).The Frequency of Risk Factors for Cleft Lip and Palate in Mexico: A Systematic Review. Diagnostics,14(16)
OAGamarra, J., Álvarez-Ordaz, D., Molina-Frechero, N. and 8 more (...) (2024).Association between fluoride intake from drinking water and severity of dental fluorosis in Northern and Western Mexico: systematic review and meta-analysis. BMC Oral Health,24(1) | 6 |
OASilveira, F.M., Schuch, L.F., Pereira-Prado, V. and 7 more (...) (2024).Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature. Medicina Oral Patologia Oral y Cirugia Bucal,29(4) e509-e516
OAHolguín-Meráz, C., Martínez-Martínez, R.E., Zaragoza-Contreras, E.A. and 7 more (...) (2024).Antibacterial Effect of Silver Nanoparticles against Oral Biofilms in Subjects with Motor and Intellectual Disabilities. Journal of Functional Biomaterials,15(7)
Lavalle-Carrasco, J., Vergara-Onofre, M., González-González, R. and 4 more (...) (2023).A Systematic Review and Meta-Analysis of the Relationship Between the Severity of Dental Fluorosis and Fluoride Biomarkers in Endemic Areas. Biological Trace Element Research,201(3) 1051-1062| 3| 6 |
OAGonzález-González, R., Bologna-Molina, R., Molina-Frechero, N. (2023).Editorial: Fluoride exposure, dental fluorosis, and health. Frontiers in Oral Health,4
Silveira, F.M., Molina-Frechero, N., López-Verdín, S. and 8 more (...) (2023).Connexin 43 expression in tooth germ and benign odontogenic tumors. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,135(5) 661-668
OAJuárez-López, M.L.A., Salazar-Treto, L.V., Hernández-Monjaraz, B. and 1 more (...) (2023).Etiological Factors of Molar Incisor Hypomineralization: A Systematic Review and Meta-Analysis. Dentistry Journal,11(5)
OABautista-Carbajal, A., Villanueva-Arriaga, R.E., Páez-Arenas, A. and 3 more (...) (2023).Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin v in Osteoclasts Cultured in Vitro. International Journal of Dentistry,2023
OAHernández-Venegas, P.A., Martínez-Martínez, R.E., Zaragoza-Contreras, E.A. and 6 more (...) (2023).Bactericidal Activity of Silver Nanoparticles on Oral Biofilms Related to Patients with and without Periodontal Disease. Journal of Functional Biomaterials,14(6)
OAPrieto-Correa, J.R., Bologna-Molina, R., González-González, R. and 5 more (...) (2023).DNA oxidative damage in oral cancer: 8-hydroxy-2´-deoxyguanosine immunoexpression assessment. Medicina Oral Patologia Oral y Cirugia Bucal,28(6) e530-e538| 3 |
OAGonzález-Casamada, C., Nevarez-Rascón, M., Nevarez-Rascón, A. and 5 more (...) (2022).Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review. Dentistry Journal,10(11)
OAGómez-Sánchez, E., Franco-de la Torre, L., Bologna-Molina, R.E. and 6 more (...) (2022).Local Tramadol Improves the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis. Healthcare (Switzerland),10(10)
OAJuárez-López, M.L.A., Miranda-Marin, M., Lavalle-Carrasco, J. and 3 more (...) (2022).Association of Age and Temperamental Traits with Children’s Behaviour during Dental Treatment. International Journal of Environmental Research and Public Health,19(3)
OAGonzález-Morelos, M., la Torre, L.F., Franco-González, D.L. and 5 more (...) (2022).Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis. Healthcare (Switzerland),10(6)
OAFranco-de la Torre, L., Gómez-Sánchez, E., Serafín-Higuera, N.A. and 5 more (...) (2022).Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis. Pharmaceuticals,15(7)
Jarquin-Yañez, L., Calderon Hernandez, J., Gonzalez, L. and 2 more (...) (2022).Urinary fluoride and micronutrients intake in children from San Luis Potosi, Mexico. International Journal of Environmental Health Research,32(6) 1304-1312| 6 |
OALópez-Verdín, S., Bologna-Molina, R., Aguirre-Cortes, D. and 4 more (...) (2022).Predisposing factors for taste loss in a group evaluated for SARS-CoV-2. Oral Diseases,28(2) 2544-2547| 3 |
OACruz-Ávila, J., Hernández-Pérez, E., González-González, R. and 2 more (...) (2022).Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review. Dentistry Journal,10(12) | 3 |
OAGuardado-Luevanos, I., Bologna-Molina, R., Zepeda-Nuño, J.S. and 5 more (...) (2022).Self-Reported Periodontal Disease and Its Association with SARS-CoV-2 Infection. International Journal of Environmental Research and Public Health,19(16) | 3 |
OADerderian, N., Pereira-Prado, V., Hernandez, M. and 7 more (...) (2022).Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma. Medicina Oral Patologia Oral y Cirugia Bucal,27(5) e403-e409| 3 |
OAGonzález, J.J.P., Romero, M.G.O., Bermúdez, B.S. and 4 more (...) (2022).Triacylglycerides and Cholesterol in Organic Milk from Chiapas, Mexico. Animals,12(10) | 2 |
OALa Torre, L.F.-D., Franco-González, D.L., Brennan-Bourdon, L.M. and 3 more (...) (2021).Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis. Behavioural Neurology,2021
Vázquez, C.C.R., Tolentino, R.G., Meléndez, A.B. and 8 more (...) (2021).EDUCATIONAL INTERVENTION TO DECREASE THE PREVALENCE OF OBESITY IN ADOLESCENTS OF MEXICO CITY, MEXICO. Revista Espanola de Nutricion Comunitaria,27(3) 166-176| 3 |
OASánchez-Pérez, L., Sáenz-Martínez, L.P., Molina-Frechero, N. and 3 more (...) (2021).Body mass index and dental caries, a five-year follow-up study in mexican children. International Journal of Environmental Research and Public Health,18(14) | 3 |
López-Verdín, S., Prieto-Correa, J.R., Molina-Frechero, N. and 1 more (...) (2021).Screening test for COVID-19 in dentai practice: Best options. American Journal of Dentistry,34(3) 127-131| 3 |
OAGonzález-González, R., Ortiz-Sarabia, G., Molina-Frechero, N. and 6 more (...) (2021).Epithelial–mesenchymal transition associated with head and neck squamous cell carcinomas: A review. Cancers,13(12) | 3 |
OASánchez-Romero, C., Pereira-Prado, V., Sicco, E. and 8 more (...) (2021).Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma. Medicina Oral Patologia Oral y Cirugia Bucal,26(2) e238-e245| 3 |
Sánchez-Romero, C., Carreón-Burciaga, R., Gónzalez-Gónzalez, R. and 3 more (...) (2021).Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma. Journal of Oral Pathology and Medicine,50(7) 708-715| 3 |
Pereira-Prado, V., Vigil-Bastitta, G., Sánchez-Romero, C. and 5 more (...) (2021).Immunoexpression of galectin-3 and its potential relation to hypoxia-inducible factor-1α in ameloblastomas. Biotechnic and Histochemistry,96(4) 296-301
OALavalle-Carrasco, J., Molina-Frechero, N., Nevárez-Rascón, M. and 6 more (...) (2021).Recent biomarkers for monitoring the systemic fluoride levels in exposed populations: A systematic review. International Journal of Environmental Research and Public Health,18(1) 1-14| 3| 6 |
OANevárez-Rascón, M., Adame, E., Almeida, E. and 4 more (...) (2020).Effectiveness of a microabrasion technique using 16% HCL with manual application on fluorotic teeth: A series of studies. World Journal of Clinical Cases,8(4) 743-756
OAMolina-Frechero, N., Nevarez-Rascón, M., Tremillo-Maldonado, O. and 6 more (...) (2020).Environmental exposure of arsenic in groundwater associated to carcinogenic risk in underweight children exposed to fluorides. International Journal of Environmental Research and Public Health,17(3) | 3| 6 |
OAIrigoyen-Camacho, M.E., Villanueva-Gutierrez, T., Castano-Seiquer, A. and 3 more (...) (2020).Evaluating the changes in molar incisor hypomineralization prevalence: A comparison of two cross-sectional studies in two elementary schools in Mexico City between 2008 and 2017. Clinical and Experimental Dental Research,6(1) 82-89
OAAngulo, M., Cuitiño, E., Molina-Frechero, N. and 1 more (...) (2020).The association between the prevalence of dental fluorosis and the socio-economic status and area of residence of 12-year-old students in Uruguay. Acta Odontologica Scandinavica,78(1) 26-30
OADuran-Merino, D., Molina-Frechero, N., Sánchez-Pérez, L. and 5 more (...) (2020).ENAM gene variation in students exposed to different fluoride concentrations. International Journal of Environmental Research and Public Health,17(6)
Tremillo-Maldonado, O., Molina-Frechero, N., González-González, R. and 5 more (...) (2020).DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental fluorosis. Archives of Oral Biology,110

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
25O
Trabajo de Investigación VIIPosgrado
2
25O
Trabajo de Investigación IXPosgrado
3
25O
Seminario VIIPosgrado
4
25O
Proceso Salud Enfermedad Bucal IIPosgrado
5
25P
Seminario VIPosgrado
6
25P
Trabajo de Investigación VIPosgrado
7
25P
Trabajo de Investigación VIIIPosgrado
8
25P
Proceso Salud Enfermedad Bucal IPosgrado
9
25P
Elaboración del Informe FinalPosgrado
10
25P
Elaboración del Informe FinalPosgrado
11
25I
Trabajo de Investigación VPosgrado
12
25I
Trabajo de Investigación VIIPosgrado
13
25I
Seminario VPosgrado
14
25I
Discusión de ResultadosPosgrado
15
25I
Discusión de ResultadosPosgrado
16
24O
Sistematización y Análisis de ResultadosPosgrado
17
24O
Seminario IVPosgrado
18
24O
Trabajo de Investigación IVPosgrado
19
24O
Seminario VIPosgrado
20
24O
Trabajo de Investigación VIPosgrado
21
24O
Trabajo de Investigación VIIPosgrado
22
24P
Diseño de la Investigación y Recolección de DatosPosgrado
23
24P
Trabajo de Investigación VPosgrado
24
24P
Seminario VPosgrado
25
24P
Trabajo de Investigación IIIPosgrado
26
24P
Seminario IIIPosgrado
27
24P
Elaboración del Informe FinalPosgrado
28
24P
Diseño de la Investigación y Recolección de DatosPosgrado
29
24P
Diseño de la Investigación y Recolección de DatosPosgrado
30
24P
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
31
24P
Elaboración del Informe FinalPosgrado
32
24I
Trabajo de Investigación IVPosgrado
33
24I
Discusión de ResultadosPosgrado
34
24I
Discusión de ResultadosPosgrado
35
24I
Proceso Salud Enfermedad Bucal IIPosgrado
36
24I
Proceso Salud Enfermedad Bucal IIPosgrado
37
24I
Seminario IVPosgrado
38
24I
Trabajo de Investigación IIPosgrado
39
24I
Seminario IIPosgrado
40
24I
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
41
23O
Trabajo de Investigación IIIPosgrado
42
23O
Seminario IIIPosgrado
43
23O
Proceso Salud Enfermedad Bucal IPosgrado
44
23O
Trabajo de Investigación IPosgrado
45
23O
Seminario IPosgrado
46
23O
Sistematización y Análisis de ResultadosPosgrado
47
23O
Proceso Salud Enfermedad Bucal IPosgrado
48
23O
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
49
23O
Sistematización y Análisis de ResultadosPosgrado
50
23P
Anatomía y Fisiología en el Diagnostico y Manejo ClínicoLicenciatura
51
23P
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
52
23P
Seminario IIPosgrado
53
23P
Trabajo de Investigación IIPosgrado
54
23P
Diseño de la Investigación y Recolección de DatosPosgrado
55
23P
Diseño de la Investigación y Recolección de DatosPosgrado
56
23I
Proceso Salud Enfermedad Bucal IIPosgrado
57
23I
Trabajo de Investigación VIPosgrado
58
23I
Seminario VIPosgrado
59
23I
Trabajo de Investigación IPosgrado
60
23I
Seminario IPosgrado
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