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Perfil investigador
Esp
Dr. Nelly María Molina Frechero

Professor
Departament of Health Care

Division of Biological and Health Sciences


Emeritus
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Xochimilco Campus

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Sites of interest

• Web of Science

Sustainable Development Goals

• 3 Good Health and Well-being

• 6 Clean Water and Sanitation


Research interests

• Preventive dentistry
• Pathogenesis of dental fluorosis
• Genetics of oral pathologies
• Water toxicology
• Oral pathology and medicine

Profile

Doctor Nelly Molina-Frechero is a Professor working in the area of clinical sciences of the Department of Health Care; her lines of research are Preventive Dentistry, Dental Fluorosis and Caries, Water Toxicology, Basic Sciences in Dentistry, Genetics of Oral Diseases, Pathology and Oral Medicine.

She belongs to the National System of Researchers with Level III of CONACYT, is responsible for the consolidated academic group Research in Oral Health, and has a PRODEP profile.

Professor Molina participated in the creation of the Master's Degree in Dental Sciences, where she is the first Coordinator. Training of human resources: B.Sc. 48, Master's 16, and Doctorate 4.

At the undergraduate level, she has taught in the Divisional Trunk of CBS, in the career of Stomatology. At the Postgraduate level in the Doctorate in Biological and Health Sciences and Master's Degree in Dental Sciences.

In other institutions in the Master's Degree in Stomatology Sciences Universidad Juarez del Estado de Durango, Master's Degree in Pediatric Stomatology. Universidad Autónoma de Chihuahua, Master's Degree in Oral Biology. School of Dentistry UDELAR Uruguay.

Publication of more than 100 scientific articles and more than 200 specialized events at national and international level.

She participates in institutionally approved research projects and collaborates in international projects. Implemented agreements and joint works with universities at national and international level. At the national level with the Universidad Nacional Autónoma de México (UNAM), the Universidad Juárez del Estado de Durango, the Universidad de Guadalajara, the Universidad Autónoma de Chihuahua and the Universidad de San Luis Potosí, among others. Internationally with the University of Buenos Aires UBA, the University of Uruguay UDELAR and the Catholic University, the Cooperative University of Colombia and the University of Modena Italy.

The research line is integrated to the objectives of the institution in relation to sustainable development where the goals are to provide attention to vulnerable groups through actions to reduce the gaps of social and territorial inequality between different areas of the Mexican Republic and in relation to drinking water, which aims to promote and ensure access to quality and quantity of drinking water, prioritizing historically discriminated groups, ensuring the health of the population and the ecosystems and watersheds.

Evaluator of international journals such as Oral Diseases, Community Dent Oral Epidemiology, BMC Oral Health. Int J Environ Res Public Health, Med Oral Patol Oral Cir Bucal, Dis Markers, Med Sci Monit, among others. Accredited evaluator of CONACYT, PRODEP and at international level of the National Agency of Science and Technology ANII of Uruguay.



Information provided by the academic staff

Research interests

• Preventive dentistry
• Pathogenesis of dental fluorosis
• Genetics of oral pathologies
• Water toxicology
• Oral pathology and medicine

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAGamarra, J., Pierdant-Rodríguez, A., Molina-Frechero, N. (2026).COMPARISON OF FLUORIDE CONCENTRATION AND PH LEVELS IN DRINKING WATER BETWEEN RAINY AND DRY SEASONS IN TLÁHUAC, MEXICO CITY. Revista Cientifica Odontologica,14(3) 6
OASánchez-Pérez, L., Sáenz Martínez, L.P., Molina Frechero, N. and 2 more (...) (2026).Predictors of Dental Caries Increment in Schoolchildren: A Longitudinal Study of Salivary and Behavioral Risk Factors. Dentistry Journal,14(6)
OAIsiordia-Espinoza, M.A., Hernández-Gómez, A., Bologna-Molina, R. and 5 more (...) (2026).Cyclooxygenase-2 selective inhibitors increase the risk of alveolar osteitis: A systematic review and meta-analysis. Medicina Oral Patologia Oral y Cirugia Bucal,31(3) 363-370
Aragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Author's Reply to the Comment on "Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review". Oral and Maxillofacial Surgery,29(1)
Aragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review. Oral and Maxillofacial Surgery,29(1)
Lavalle-Carrasco, J., Molina-Frechero, N., López-Verdín, S. and 1 more (...) (2025).Health Implications of Proinflammatory Cytokine Activity at Different Levels of Fluoride Exposure: A Systematic Review. Journal of Applied Toxicology,45(7) 1191-12023|6
OASilveira, F.M., Schuch, L.F., Pereira-Prado, V. and 7 more (...) (2025).Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma. World Journal of Experimental Medicine,15(2) 3
OAIsiordia-Espinoza, M.A., Aragon-Martinez, O.H., Serafín-Higuera, N.A. and 6 more (...) (2025).A Quantitative Systematic Review on the Analgesic Efficacy and Adverse Effects of Ketorolac in Third Molar Surgery. Clinics and Practice,15(4)
OAAragon-Martinez, O.H., Gómez-Sánchez, E., Bologna-Molina, R. and 6 more (...) (2025).Correction to: Pain control and adverse effects of parecoxib after wisdom teeth surgery: a quantitative systematic review (Oral and Maxillofacial Surgery, (2025), 29, 1, (123), 10.1007/s10006-025-01416-5). Oral and Maxillofacial Surgery,29(1)
OABarrón-Márquez, M.C., González-González, R., Bobadilla-Morales, L. and 5 more (...) (2025).Retracted: Cowden Syndrome and Oral Lesions: A Case Report Using MLPA. The American journal of case reports,26
OABarrón-Márquez, M.C., González-González, R., Bobadilla-Morales, L. and 5 more (...) (2025).Cowden Syndrome and Oral Lesions: A Case Report Using MLPA. American Journal of Case Reports ,263
OALavalle-Carrasco, J., Molina-Frechero, N., Hernández-Pérez, E. and 3 more (...) (2025).Systemic fluoride levels in toenails as biomarkers of exposure and their association with the severity of dental fluorosis in Mexican schoolchildren–a cross-sectional study. Biomarkers,30(2) 140-146
OAGamarra, J., Molina-Frechero, N., Gaona, E. and 3 more (...) (2025).FLUORIDE CONCENTRATION IN DRINKING WATER SOURCES AND ASSOCIATED HEALTH RISKS. Journal of Oral Research,14424-4333|6
OAMora-Falcón, I.J., Amador-Beas, I.A., Bologna-Molina, R. and 5 more (...) (2025).Analgesic Efficacy of Postoperative Ibuprofen in Third Molar Surgery: A Meta-Analysis. Oral,5(3)
OAHolguín-Meráz, C., Martínez-Martínez, R.E., Zaragoza-Contreras, E.A. and 7 more (...) (2024).Antibacterial Effect of Silver Nanoparticles against Oral Biofilms in Subjects with Motor and Intellectual Disabilities. Journal of Functional Biomaterials,15(7)
OAGamarra, J., Álvarez-Ordaz, D., Molina-Frechero, N. and 8 more (...) (2024).Association between fluoride intake from drinking water and severity of dental fluorosis in Northern and Western Mexico: systematic review and meta-analysis. BMC Oral Health,24(1) 6
OASilveira, F.M., Schuch, L.F., Pereira-Prado, V. and 7 more (...) (2024).Frequency of BRAF V600E immunoexpression in ameloblastomas: a multi-institutional analysis of 86 cases in Latin America and comprehensive review of the literature. Medicina Oral Patologia Oral y Cirugia Bucal,29(4) e509-e516
OALópez-Verdín, S., Solorzano-López, J.A., Bologna-Molina, R. and 4 more (...) (2024).The Frequency of Risk Factors for Cleft Lip and Palate in Mexico: A Systematic Review. Diagnostics,14(16)
OAGonzález-González, R., Bologna-Molina, R., Molina-Frechero, N. (2023).Editorial: Fluoride exposure, dental fluorosis, and health. Frontiers in Oral Health,4
OAJuárez-López, M.L.A., Salazar-Treto, L.V., Hernández-Monjaraz, B. and 1 more (...) (2023).Etiological Factors of Molar Incisor Hypomineralization: A Systematic Review and Meta-Analysis. Dentistry Journal,11(5)
OABautista-Carbajal, A., Villanueva-Arriaga, R.E., Páez-Arenas, A. and 3 more (...) (2023).Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin v in Osteoclasts Cultured in Vitro. International Journal of Dentistry,2023
OAPrieto-Correa, J.R., Bologna-Molina, R., González-González, R. and 5 more (...) (2023).DNA oxidative damage in oral cancer: 8-hydroxy-2´-deoxyguanosine immunoexpression assessment. Medicina Oral Patologia Oral y Cirugia Bucal,28(6) e530-e5383
OAHernández-Venegas, P.A., Martínez-Martínez, R.E., Zaragoza-Contreras, E.A. and 6 more (...) (2023).Bactericidal Activity of Silver Nanoparticles on Oral Biofilms Related to Patients with and without Periodontal Disease. Journal of Functional Biomaterials,14(6)
Lavalle-Carrasco, J., Vergara-Onofre, M., González-González, R. and 4 more (...) (2023).A Systematic Review and Meta-Analysis of the Relationship Between the Severity of Dental Fluorosis and Fluoride Biomarkers in Endemic Areas. Biological Trace Element Research,201(3) 1051-10623|6
Silveira, F.M., Molina-Frechero, N., López-Verdín, S. and 8 more (...) (2023).Connexin 43 expression in tooth germ and benign odontogenic tumors. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,135(5) 661-668
OACruz-Ávila, J., Hernández-Pérez, E., González-González, R. and 2 more (...) (2022).Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review. Dentistry Journal,10(12) 3
OAJuárez-López, M.L.A., Miranda-Marin, M., Lavalle-Carrasco, J. and 3 more (...) (2022).Association of Age and Temperamental Traits with Children’s Behaviour during Dental Treatment. International Journal of Environmental Research and Public Health,19(3)
OAGonzález, J.J.P., Romero, M.G.O., Bermúdez, B.S. and 4 more (...) (2022).Triacylglycerides and Cholesterol in Organic Milk from Chiapas, Mexico. Animals,12(10) 2
OALópez-Verdín, S., Bologna-Molina, R., Aguirre-Cortes, D. and 4 more (...) (2022).Predisposing factors for taste loss in a group evaluated for SARS-CoV-2. Oral Diseases,28(2) 2544-25473
OAGonzález-Morelos, M., la Torre, L.F., Franco-González, D.L. and 5 more (...) (2022).Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis. Healthcare (Switzerland),10(6)
OAGuardado-Luevanos, I., Bologna-Molina, R., Zepeda-Nuño, J.S. and 5 more (...) (2022).Self-Reported Periodontal Disease and Its Association with SARS-CoV-2 Infection. International Journal of Environmental Research and Public Health,19(16) 3
OAFranco-de la Torre, L., Gómez-Sánchez, E., Serafín-Higuera, N.A. and 5 more (...) (2022).Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis. Pharmaceuticals,15(7)
OAGonzález-Casamada, C., Nevarez-Rascón, M., Nevarez-Rascón, A. and 5 more (...) (2022).Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review. Dentistry Journal,10(11)
OAGómez-Sánchez, E., Franco-de la Torre, L., Bologna-Molina, R.E. and 6 more (...) (2022).Local Tramadol Improves the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis. Healthcare (Switzerland),10(10)
OADerderian, N., Pereira-Prado, V., Hernandez, M. and 7 more (...) (2022).Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma. Medicina Oral Patologia Oral y Cirugia Bucal,27(5) e403-e4093
Jarquin-Yañez, L., Calderon Hernandez, J., Gonzalez, L. and 2 more (...) (2022).Urinary fluoride and micronutrients intake in children from San Luis Potosi, Mexico. International Journal of Environmental Health Research,32(6) 1304-13126
OALa Torre, L.F.-D., Franco-González, D.L., Brennan-Bourdon, L.M. and 3 more (...) (2021).Analgesic Efficacy of Etoricoxib following Third Molar Surgery: A Meta-analysis. Behavioural Neurology,2021
Vázquez, C.C.R., Tolentino, R.G., Meléndez, A.B. and 8 more (...) (2021).EDUCATIONAL INTERVENTION TO DECREASE THE PREVALENCE OF OBESITY IN ADOLESCENTS OF MEXICO CITY, MEXICO. Revista Espanola de Nutricion Comunitaria,27(3) 166-1763
Pereira-Prado, V., Vigil-Bastitta, G., Sánchez-Romero, C. and 5 more (...) (2021).Immunoexpression of galectin-3 and its potential relation to hypoxia-inducible factor-1α in ameloblastomas. Biotechnic and Histochemistry,96(4) 296-301
Sánchez-Romero, C., Carreón-Burciaga, R., Gónzalez-Gónzalez, R. and 3 more (...) (2021).Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma. Journal of Oral Pathology and Medicine,50(7) 708-7153
López-Verdín, S., Prieto-Correa, J.R., Molina-Frechero, N. and 1 more (...) (2021).Screening test for COVID-19 in dentai practice: Best options. American Journal of Dentistry,34(3) 127-1313
OASánchez-Romero, C., Pereira-Prado, V., Sicco, E. and 8 more (...) (2021).Expression of caveolin-1 in tooth germ, ameloblastoma and ameloblastic carcinoma. Medicina Oral Patologia Oral y Cirugia Bucal,26(2) e238-e2453
OAGonzález-González, R., Ortiz-Sarabia, G., Molina-Frechero, N. and 6 more (...) (2021).Epithelial–mesenchymal transition associated with head and neck squamous cell carcinomas: A review. Cancers,13(12) 3
OALavalle-Carrasco, J., Molina-Frechero, N., Nevárez-Rascón, M. and 6 more (...) (2021).Recent biomarkers for monitoring the systemic fluoride levels in exposed populations: A systematic review. International Journal of Environmental Research and Public Health,18(1) 1-143|6
OASánchez-Pérez, L., Sáenz-Martínez, L.P., Molina-Frechero, N. and 3 more (...) (2021).Body mass index and dental caries, a five-year follow-up study in mexican children. International Journal of Environmental Research and Public Health,18(14) 3
Tremillo-Maldonado, O., Molina-Frechero, N., González-González, R. and 5 more (...) (2020).DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental fluorosis. Archives of Oral Biology,110
OAAngulo, M., Cuitiño, E., Molina-Frechero, N. and 1 more (...) (2020).The association between the prevalence of dental fluorosis and the socio-economic status and area of residence of 12-year-old students in Uruguay. Acta Odontologica Scandinavica,78(1) 26-30
OAIrigoyen-Camacho, M.E., Villanueva-Gutierrez, T., Castano-Seiquer, A. and 3 more (...) (2020).Evaluating the changes in molar incisor hypomineralization prevalence: A comparison of two cross-sectional studies in two elementary schools in Mexico City between 2008 and 2017. Clinical and Experimental Dental Research,6(1) 82-89
OANevárez-Rascón, M., Adame, E., Almeida, E. and 4 more (...) (2020).Effectiveness of a microabrasion technique using 16% HCL with manual application on fluorotic teeth: A series of studies. World Journal of Clinical Cases,8(4) 743-756
OADuran-Merino, D., Molina-Frechero, N., Sánchez-Pérez, L. and 5 more (...) (2020).ENAM gene variation in students exposed to different fluoride concentrations. International Journal of Environmental Research and Public Health,17(6)
OAMolina-Frechero, N., Nevarez-Rascón, M., Tremillo-Maldonado, O. and 6 more (...) (2020).Environmental exposure of arsenic in groundwater associated to carcinogenic risk in underweight children exposed to fluorides. International Journal of Environmental Research and Public Health,17(3) 3|6

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26P
Sistematización y Análisis de ResultadosPosgrado
2
26P
Sistematización y Análisis de ResultadosPosgrado
3
26P
Sistematización y Análisis de ResultadosPosgrado
4
26P
Seminario VIIPosgrado
5
26P
Trabajo de Redacción de Tesis IIPosgrado
6
26P
Trabajo de Investigación IXPosgrado
7
26P
Trabajo de Investigación VIIIPosgrado
8
26I
Diseño de la Investigación y Recolección de DatosPosgrado
9
26I
Diseño de la Investigación y Recolección de DatosPosgrado
10
26I
Diseño de la Investigación y Recolección de DatosPosgrado
11
26I
Trabajo de Investigación VIIIPosgrado
12
26I
Trabajo de Redacción de Tesis IPosgrado
13
25O
Trabajo de Investigación VIIPosgrado
14
25O
Proceso Salud Enfermedad Bucal IIPosgrado
15
25O
Seminario VIIPosgrado
16
25O
Trabajo de Investigación IXPosgrado
17
25P
Elaboración del Informe FinalPosgrado
18
25P
Elaboración del Informe FinalPosgrado
19
25P
Proceso Salud Enfermedad Bucal IPosgrado
20
25P
Seminario VIPosgrado
21
25P
Trabajo de Investigación VIPosgrado
22
25P
Trabajo de Investigación VIIIPosgrado
23
25I
Trabajo de Investigación VPosgrado
24
25I
Discusión de ResultadosPosgrado
25
25I
Discusión de ResultadosPosgrado
26
25I
Seminario VPosgrado
27
25I
Trabajo de Investigación VIIPosgrado
28
24O
Trabajo de Investigación VIIPosgrado
29
24O
Seminario IVPosgrado
30
24O
Seminario VIPosgrado
31
24O
Sistematización y Análisis de ResultadosPosgrado
32
24O
Trabajo de Investigación IVPosgrado
33
24O
Trabajo de Investigación VIPosgrado
34
24P
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
35
24P
Trabajo de Investigación VPosgrado
36
24P
Trabajo de Investigación IIIPosgrado
37
24P
Diseño de la Investigación y Recolección de DatosPosgrado
38
24P
Diseño de la Investigación y Recolección de DatosPosgrado
39
24P
Diseño de la Investigación y Recolección de DatosPosgrado
40
24P
Elaboración del Informe FinalPosgrado
41
24P
Elaboración del Informe FinalPosgrado
42
24P
Seminario IIIPosgrado
43
24P
Seminario VPosgrado
44
24I
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
45
24I
Trabajo de Investigación IVPosgrado
46
24I
Discusión de ResultadosPosgrado
47
24I
Discusión de ResultadosPosgrado
48
24I
Proceso Salud Enfermedad Bucal IIPosgrado
49
24I
Proceso Salud Enfermedad Bucal IIPosgrado
50
24I
Seminario IIPosgrado
51
24I
Seminario IVPosgrado
52
24I
Trabajo de Investigación IIPosgrado
53
23O
Crecimiento y Desarrollo del Infante y del Pre-EscolarLicenciatura
54
23O
Trabajo de Investigación IIIPosgrado
55
23O
Proceso Salud Enfermedad Bucal IPosgrado
56
23O
Proceso Salud Enfermedad Bucal IPosgrado
57
23O
Seminario IPosgrado
58
23O
Seminario IIIPosgrado
59
23O
Sistematización y Análisis de ResultadosPosgrado
60
23O
Sistematización y Análisis de ResultadosPosgrado
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