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Perfil investigador
Esp
Dr. Francisco Cruz Sosa

Professor
Departament of Biotechnology

Division of Biological and Health Sciences


Level 2
Member of the National System of Researchers
(SNII)

Agriculture, Farming, Forestry and Ecosystem Sciences



Iztapalapa Campus

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Sustainable Development Goals

• 3 Good Health and Well-being

• 4 Quality Education

• 15 Life on Land


Research interests

• Plant Biotechnology
• Plant cell cultures
• Secondary metabolites
• Plant cell suspension culture
• Protection of bioactive compounds

Profile

Professor Francisco Cruz Sosa obtained a chemical degree from the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM) in 1979, a master of science from the UNAM in 1984 a doctorate from the UNAM in 1988. He entered the Biotechnology Department of the Universidad Autónoma Metropolitana (UAM) Iztapalapa Campus in 1984, where he is currently a Professor with a permanent scholarship level. Since joining the Biotechnology Department, he was appointed professor of the general chemistry and organic chemistry courses, and from October 1989 to August 2008, he was head of the Natural Products Area of the Biotechnology Department.

His research focuses on the production of secondary metabolites as bioactive compounds of interest from plants and plant organs in plant cell cultures. Furthermore, he participates in the design of micro and nanoencapsulation systems to protect secondary metabolites as bioactive compounds and with controlled release capacity. He is the author of 86 publications, of which there are registered in indexed journals with peer review and impact factor 67 in Web of Science and 64 in Scopus, eight book chapters, and 11 diffusion articles.

He has taught continuously since 1984, as Associate Professor from 1984 to 1988 at the UAM Iztapalapa Campus, and as Professor from 1989 to date in the degrees of Food Engineering and Industrial Biochemical Engineering in the Division of Biological Sciences and of the Health of the UAM Iztapalapa Campus. He has organized five national congresses and presented six invited conferences. He is a member of the core of the Postgraduate in Biotechnology (International Quality) under his direction; two bachelor theses, eleven master's, and 22 doctorate theses have been completed.

In the Biotechnology Department of the UAM Iztapalapa Campus, he was the founder of the Laboratory of Plant Tissue cultures of which he is currently responsible for, and participate in internal research projects of the UAM Iztapalapa Campus and in research projects sponsored by CONACYT and PRODEP. In addition, he collaborates with researchers from other research groups at UAM and from external higher education institutions.

In recognition of his academic career, he has been invited to participate in evaluation committees of CONACYT: 1) Basic Science 2) CONACYT-PEI 3) National Problems 4) Postdoctoral Stays Abroad 5) Sabbatical Stays Abroad 6) FOMIX GTO-2018-01 7) FOMIX-Hidalgo 8) CONACYT-CDTI-2015. 9) Science of Border.

He has been invited to review research articles from indexed journals with impact factor 1) Elsevier ((Asian Pacific Journal of Tropical Medicine, Biocatalysis and Agricultural Biotechnology, Current Plant Biology, Environmental Science and Pollution Research, Food Hydrocolloids, Industrial Crops and Products, Journal of Ethnopharmacology, Journal of Functional Foods, South African Journal of Botany, The Plant Biotechnology Journal) 2) MDPI (Molecules). 3) Springer (Bioprocess and Biosystems Engineering, BMC Plant Biology, Cytotechnology, Environmental Science and Pollution Research, In vitro Plant Development Biology Plant Cell Tissue and Organ Culture, Scientific Reports). 4) Agronomic Act (National University of Colombia). 5) Bentham Science (The Natural Products Journal) 6) Hindawi (International Journal of Forestry Research, International Journal of Inflammation, Journal of Food Quality) 7) UAM-Iztapalapa (Mexican Journal of Chemical Engineering).



Information provided by the academic staff

Research interests

• Plant Biotechnology
• Plant cell cultures
• Secondary metabolites
• Plant cell suspension culture
• Protection of bioactive compounds

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OASánchez-Ramos, M., Guerrero-Alonso, A., Buendía-González, L. and 4 more (...) (2026).Therapeutic Value of Plant Saponins, Challenges and Opportunities: A Review. Natural Product Communications,21(2)
Nieto-Trujillo, A., Luria-Pérez, R., Cruz-Sosa, F. and 8 more (...) (2025).Metabolomic and Pharmacological Approaches for Exploring the Potential of Tanacetum parthenium L. Root Culture as a Source of Bioactive Phytochemicals. International Journal of Molecular Sciences,26(15)
OAHurtado-Díaz, I., Teta-Talixtacta, R., Bernabé-Antonio, A. and 5 more (...) (2025).GC-MS-Identified Alkamides and Evaluation of the Anti-Inflammatory, Antibacterial, and Antioxidant Activities of Wild Acmella radicans. International Journal of Molecular Sciences,26(16)
Gutiérrez-Rebolledo, G.A., Pérez-González, M.Z., Sánchez-Ramos, M. and 1 more (...) (2025).In vitro plant cultures as a viable biotechnological tool for the biosynthesis of steroidal hormones of clinical interest. Whole Cell Biocatalysis: Fundamentals and Applications,203-251| 9 |
Oidor-Chan, V.H., Arellano-Mauricio, A.B., del Valle-Mondragón, L. and 9 more (...) (2024).Chemical analysis of freeze-dried seeds of Stenocereus stellatus (white tunillo) components and evaluation of their effect on prediabetes reversion in an experimental model in female Wistar rats. Food and Function,15(18) 9235-9253
OAVazquez-Marquez, A.M., Bernabé-Antonio, A., Correa-Basurto, J. and 5 more (...) (2024).Changes in Growth and Heavy Metal and Phenolic Compound Accumulation in Buddleja cordata Cell Suspension Culture under Cu, Fe, Mn, and Zn Enrichment. Plants,13(8)
OAHurtado-Díaz, I., Ramírez-Cisneros, M.Á., Alvarez, L. and 5 more (...) (2024).Metabolites Profile of Extracts and Fractions of Erythroxylum mexicanum Kunth by UHPLC-QTOF-MS/MS and its Antibacterial, Cytotoxic and Nitric Oxide Inhibitory Activities. Chemistry and Biodiversity,21(3) | 3 |
OADomínguez-Colín, J.A., Buendía-González, L., Hernández-Jaimes, C. and 2 more (...) (2024).Cytotoxic activity of callus extract from Vachellia farnesiana (L) Wight & Arn.. 3 Biotech,14(10) | 3 |
OAGallardo-Ignacio, J., Santibáñez, A., Oropeza-Mariano, O. and 6 more (...) (2023).Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties. Molecules,28(12)
OAViera-Escareño, V., Perez-Molphe Balch, E., Gómez-Aguirre, Y.A. and 4 more (...) (2023).Alkaloid and Nitrogenated Compounds from Different Sections of Coryphantha macromeris Plants and Callus Cultures. Applied Sciences (Switzerland),13(17) | 15 |
OASánchez-Ramos, M., Marquina-Bahena, S., Alvarez, L. and 4 more (...) (2023).Obtaining 2,3-Dihydrobenzofuran and 3-Epilupeol from Ageratina pichinchensis (Kunth) R.King & Ho.Rob. Cell Cultures Grown in Shake Flasks under Photoperiod and Darkness, and Its Scale-Up to an Airlift Bioreactor for Enhanced Production. Molecules,28(2)
OAMotolinia-Alcántara, E.A., Franco-Vásquez, A.M., Nieto-Camacho, A. and 4 more (...) (2023).Phenolic Compounds from Wild Plant and In Vitro Cultures of Ageratina pichichensis and Evaluation of Their Antioxidant Activity. Plants,12(5)
OABarrera, K., González-Cortazar, M., Reyes-Pérez, R. and 5 more (...) (2023).Production of Two Isomers of Sphaeralcic Acid in Hairy Roots from Sphaeralcea angustifolia. Plants,12(5)
OASánchez-Ramos, M., Encarnación-García, J.G., Marquina-Bahena, S. and 5 more (...) (2023).Cytotoxic Activity of Wild Plant and Callus Extracts of Ageratina pichinchensis and 2,3-Dihydrobenzofuran Isolated from a Callus Culture. Pharmaceuticals,16(10) | 3 |
OAGallardo-Ignacio, J., Nicasio-Torres, P., Santibáñez, A. and 2 more (...) (2022).Ethnopharmacological study of the genus Coffea and compounds of biological importance Estudio etnofarmacológico del género Coffea y compuestos de importancia biológica. Revista Mexicana de Ingeniera Quimica,21(3)
OACornejo-Campos, J., Gómez-Aguirre, Y.A., Velázquez-Martínez, J.R. and 5 more (...) (2022).Impact of the Cooking Process on Metabolite Profiling of Acanthocereus tetragonus, a Plant Traditionally Consumed in Mexico. Molecules,27(12)
Joaquín-Cruz, E., Hernández-Rodríguez, L., Jiménez-Alvarado, R. and 3 more (...) (2022).Water-in-oil nanoemulsions loaded with Ardisia compressa K. bioactive compounds: evaluation of their physicochemical stability and functional activities. Journal of Dispersion Science and Technology,43(8) 1121-1134
OAAlbarrán-Mondragón, F.J., Orozco-Villafuerte, J., Mulia-Rodriguez, J. and 3 more (...) (2022).Total phenolic content in fruits and in in vitro cultures of Bromelia karatas L.. Revista Mexicana de Ingeniera Quimica,21(1) | 3 | 15 |
OAMartínez-Ceja, A., Romero-Estrada, A., Columba-Palomares, M.C. and 6 more (...) (2022).Anti-inflammatory, antibacterial and antioxidant activity of leaf and cell cultures extracts of Randia aculeata L. and its chemical components by GC-MS. South African Journal of Botany,144206-218| 3 |
OABernabé-Antonio, A., Sánchez-Sánchez, A., Romero-Estrada, A. and 6 more (...) (2021).Establishment of a cell suspension culture of eysenhardtia platycarpa: Phytochemical screening of extracts and evaluation of antifungal activity. Plants,10(2) 1-23
OANieto-Trujillo, A., Cruz-Sosa, F., Luria-Pérez, R. and 5 more (...) (2021).Arnica montana cell culture establishment, and assessment of its cytotoxic, antibacterial, α-amylase inhibitor, and antioxidant in vitro bioactivities. Plants,10(11) | 3 |
OACabañas-García, E., Areche, C., Gómez-Aguirre, Y.A. and 4 more (...) (2021).Biomass production and secondary metabolite identification in callus cultures of Coryphantha macromeris (Engelm.) Britton & Rose (Cactaceae), a traditional medicinal plant. South African Journal of Botany,1371-9
OASánchez-Ramos, M., Marquina-Bahena, S., Alvarez, L. and 3 more (...) (2021).Phytochemical, pharmacological, and biotechnological study of Ageratina pichinchensis: A native species of Mexico. Plants,10(10)
OAMotolinía‐alcántara, E.A., Castillo‐araiza, C.O., Rodríguez‐monroy, M. and 2 more (...) (2021).Engineering considerations to produce bioactive compounds from plant cell suspension culture in bioreactors. Plants,10(12)
Pérez-González, M.Z., Gutiérrez-Rebolledo, G.A., Jiménez-Arellanes, M.A. and 1 more (...) (2021).The chemical constituents and biological activities of Cnidoscolus chayamansa McVaugh, a Mexican medicinal species, and plant cell cultures for the production of bioactive secondary metabolites. Studies in Natural Products Chemistry,68317-346| 3 |
OAGómez-Covarrubias, S.I., Rivera-Cabrera, F., Mendoza-Gastelum, J.I. and 5 more (...) (2020).Effect of pasteurization on chemical and functional properties of xoconostle (opuntia joconostle) juice. Journal of Food Quality and Hazards Control,7(1) 11-17
OASánchez-Ramos, M., Alvarez, L., Romero-Estrada, A. and 3 more (...) (2020).Establishment of a cell suspension culture of ageratina pichinchensis (Kunth) for the improved production of anti-inflammatory compounds. Plants,9(10) 1-19
OACisneros-Tórres, D., Cruz-Sosa, F., Nicasio-Tórres, M.P. and 3 more (...) (2020).Establishment of a cell suspensioncontenidoculture from Calophyllum brasiliense and evaluation of its antioxidant and anti-inflammatory activity. Revista Mexicana de Ingeniera Quimica,19(1) 59-70
OAArano-Varela, H., Cruz-Sosa, F., Estrada-Zúñiga, M.E. and 1 more (...) (2020).Effects of phenylalanine and methyl jasmonate on verbascoside production in Buddleja cordata Kunth cell suspension cultures. South African Journal of Botany,13541-49
OAArano-Varela, H., Fernández, F.J., Estrada-Zúñiga, M.E. and 1 more (...) (2020).Verbascoside production in long-term Buddleja cordata Kunth cell suspension cultures. 3 Biotech,10(6)

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26I
Seminario IIPosgrado
2
26I
Trabajo Experimental IIIPosgrado
3
26I
Trabajo Experimental VIPosgrado
4
26I
Trabajo Experimental VIPosgrado
5
26I
Seminario de Examen PredoctoralPosgrado
6
25O
Seminario IPosgrado
7
25O
Trabajo Experimental IIPosgrado
8
25O
Trabajo Experimental VPosgrado
9
25O
Trabajo Experimental VPosgrado
10
25P
Trabajo Experimental IVPosgrado
11
25P
Trabajo Experimental IVPosgrado
12
25P
Trabajo Experimental IPosgrado
13
25I
Química Orgánica IILicenciatura
14
25I
Seminario de Proyecto DoctoralPosgrado
15
25I
Seminario de Proyecto DoctoralPosgrado
16
25I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
17
24O
Química Orgánica IILicenciatura
18
24P
Ingeniería de Alimentos ILicenciatura
19
24P
Validación FarmacéuticaLicenciatura
20
24P
Temas Selectos en Bioingeniería ILicenciatura
21
24P
Seminario de Informe TerminalPosgrado
22
24P
Seminario de Informe TerminalPosgrado
23
24P
Química Orgánica IILicenciatura
24
24I
Biología MolecularLicenciatura
25
24I
Biología MolecularLicenciatura
26
24I
Temas Selectos en Bioingeniería ILicenciatura
27
24I
Trabajo Experimental IIIPosgrado
28
24I
Trabajo Experimental IIIPosgrado
29
23O
Validación FarmacéuticaLicenciatura
30
23O
Trabajo Experimental IIPosgrado
31
23O
Trabajo Experimental IIPosgrado
32
23O
ToxicologíaLicenciatura
33
23O
Ingeniería FarmacéuticaLicenciatura
34
23O
Tecnología FarmacéuticaLicenciatura
35
23O
Química AnalíticaLicenciatura
36
23O
Laboratorio Integral de FarmaciaLicenciatura
37
23O
Ingeniería FarmacéuticaLicenciatura
38
23O
FarmacologíaLicenciatura
39
23O
Biología MolecularLicenciatura
40
23O
Biología MolecularLicenciatura
41
23O
Microbiología GeneralLicenciatura
42
23P
Paquete TecnológicoLicenciatura
43
23P
Validación FarmacéuticaLicenciatura
44
23P
Trabajo Experimental IPosgrado
45
23P
Trabajo Experimental IPosgrado
46
23P
Tecnología FarmacéuticaLicenciatura
47
23P
Seminario de Informe TerminalPosgrado
48
23P
Paquete TecnológicoLicenciatura
49
23P
Cultivo de Tejidos VegetalesPosgrado
50
23I
Biología MolecularLicenciatura
51
23I
Validación FarmacéuticaLicenciatura
52
23I
Trabajo Experimental XIIPosgrado
53
23I
Temas Selectos en Bioingeniería IIILicenciatura
54
23I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
55
23I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
56
22O
Biología MolecularLicenciatura
57
22O
Seminario de Informe TerminalPosgrado
58
22O
Temas Selectos en Bioingeniería IIILicenciatura
59
22O
Trabajo Experimental XIPosgrado
60
22P
Bioquímica Microbiana IndustrialLicenciatura
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Universidad Autónoma Metropolitana, 2026.