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Perfil investigador
Esp
Dr. Juan Francisco Cortés Benítez

Associate Professor
Departament of Biological Systems

Division of Biological and Health Sciences


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Xochimilco Campus

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Sustainable Development Goals

• 3 Good Health and Well-being


Research interests

• Computer-Aided Drug Design
• Medicinal Chemistry
• Organic synthesis
• Diabetes
• Cancer

Profile

Dr. Juan Francisco Cortés Benítez is a full-time Associate Professor at the Xochimilco Campus of the Universidad Autónoma Metropolitana (UAM). He has more than ten years of academic experience in the design and synthesis of molecules with pharmacological activity, as well as two years of industrial experience focused on the organic synthesis of bioactive compounds, both at the laboratory scale and in production plant scale-up.

He earned his degree as a Pharmaceutical Chemist Biologist (2011) from the Faculty of Chemistry at the National Autonomous University of Mexico (UNAM). He subsequently obtained his Master’s degree (2013) and Ph.D. in Chemical Sciences (2017), both with highest honors. He also completed a one-year research stay at the Centre hospitalier de l’Université Laval (CHUL) in Quebec City, Canada, where he focused on the design and organic synthesis of steroidal derivatives for the treatment of prostate cancer.

At UAM’s Xochimilco Campus, he has taught the following undergraduate courses in the Pharmaceutical Chemist Biologist program: “Synthesis and Reactivity of Organic Compounds,” “Preparation of Organic Compounds of Pharmaceutical Interest,” and “Applied Instrumental Analysis.” In the Graduate Program in Pharmaceutical Sciences, he has taught “Preparation and Evaluation of Molecules with Biological Activity and Therapeutic Application” and “Synthesis of Molecules with Biological Activity.” He also served as a faculty representative on the Academic Council of the Xochimilco Campus during the 2023–2024 term.

His research projects focus on the design—through molecular docking and molecular dynamics studies—organic synthesis, and biological evaluation of new molecules for the treatment of type 2 diabetes mellitus, obesity, and various types of cancer. He has received research funding from SECIHTI and PRODEP. In addition, he is responsible for the Molecular Modeling service of the Medicinal Chemistry platform at the Centre hospitalier de l’Université Laval (CHUL), which provides services to both industry and academia.

Dr. Cortés has supervised ten undergraduate theses, three master’s theses, and three doctoral dissertations. He is the author of 26 scientific articles and two books. He is a Level 2 member of Mexico’s National System of Researchers (SECIHTI), holds the PRODEP Desirable Profile recognition, and is a member of the Nomenclature and Terminology Committee of the Mexican Pharmacopoeia (FEUM).



Information provided by the academic staff

Research interests

• Computer-Aided Drug Design
• Medicinal Chemistry
• Organic synthesis
• Diabetes
• Cancer

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OADe-la-Cruz-Martínez, L., Martínez-Arellano, R., López-Sánchez, M. and 8 more (...) (2025).Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies. ChemMedChem,20(22) | 3 |
OAMendoza-Jasso, M.-E., Pérez-Villanueva, J., Alvarado-Rodríguez, J.G. and 2 more (...) (2024).3-Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B). ACS Omega,| 3 |
OADel Carmen Navarrete-Mondragón, R., Cortés-Benítez, F., Elena Mendieta-Wejebe, J. and 2 more (...) (2024).Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13-cis-Retinoic Acid is a PTP1B Inhibitor. ChemMedChem,19(23) | 3 |
OARodríguez-Villar, K., Cortés-Benítez, F., Palacios-Espinosa, J.F. and 1 more (...) (2024).Similarity searching for anticandidal agents employing a repurposing approach. Molecular Informatics,43(2)
OAÁlvarez-Almazán, S., Solís-Domínguez, L.C., Duperou-Luna, P. and 9 more (...) (2023).Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies. International Journal of Molecular Sciences,24(16) | 3 |
OACoronell-Tovar, A., Cortés-Benítez, F., González-Andrade, M. (2023).The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry,38(1) | 3 |
Matadamas-Martínez, F., Yépez-Mulia, L., Pérez-Koldenkova, V. and 6 more (...) (2022).Synthesis and Antitumor Activity of 2,3-Diphenyl-2H-indazole Derivatives as Potent Antitubulin Agents. ChemistrySelect,7(27) | 3 |
Poirier, D., Maltais, R., Rousseau, J.A. and 4 more (...) (2022).Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution. Bioorganic Chemistry,129| 3 |
OAPérez-Villanueva, J., Matadamas-Martínez, F., Yépez-Mulia, L. and 9 more (...) (2021).Synthesis and cytotoxic activity of combretastatin a-4 and 2,3-diphenyl-2h-indazole hybrids. Pharmaceuticals,14(8) | 3 |
OADe-La-cruz-martínez, L., Duran-Becerra, C., González-Andrade, M. and 8 more (...) (2021).Indole-and pyrazole-glycyrrhetinic acid derivatives as ptp1b inhibitors: Synthesis, in vitro and in silico studies. Molecules,26(14) | 3 |
Cortés-Benítez, F., Roy, J., Perreault, M. and 2 more (...) (2021).16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies. Journal of Steroid Biochemistry and Molecular Biology,210| 3 |
Pérez-Villanueva, J., Yépez-Mulia, L., Rodríguez-Villar, K. and 3 more (...) (2021).The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. European Journal of Medicinal Chemistry,211
OARodríguez-Villar, K., Hernández-Campos, A., Yépez-Mulia, L. and 8 more (...) (2021).Design, synthesis and anticandidal evaluation of indazole and pyrazole derivatives. Pharmaceuticals,14(3) 1-19
OARodríguez-Villar, K., Yépez-Mulia, L., Cortés-Gines, M. and 7 more (...) (2021).Synthesis, antiprotozoal activity, and cheminformatic analysis of 2-phenyl-2h-indazole derivatives. Molecules,26(8)

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
25O
Proyecto de Investigación IIIPosgrado
2
25O
Temas Selectos de Diseño, Obtención y Evaluación de Fármacos y BiomoléculasPosgrado
3
25O
Seminario de Investigación IIPosgrado
4
25O
Seminario de Avances de Investigación IIIPosgrado
5
25O
Trabajo de Investigación IIIPosgrado
6
25O
Trabajo de Redacción de Tesis IPosgrado
7
25O
Trabajo de Redacción de Tesis IIIPosgrado
8
25O
Síntesis y Reactividad de los Compuestos OrgánicosLicenciatura
9
25P
Trabajo de Investigación IIPosgrado
10
25P
Trabajo de Redacción de Tesis IIPosgrado
11
25P
Trabajo de Investigación IXPosgrado
12
25P
Seminario de Avances de Investigación VIIPosgrado
13
25P
Seminario de Avances de Investigación IIPosgrado
14
25P
Seminario de Investigación IPosgrado
15
25P
Obtención y Evaluación de Moléculas con Actividad Biológica y Aplicación TerapéuticaPosgrado
16
25P
Proyecto de Investigación IIPosgrado
17
25P
Análisis Instrumental AplicadoLicenciatura
18
25I
Obtención de Compuestos Orgánicos de Interés FarmacéuticoLicenciatura
19
25I
Proyecto de Investigación IPosgrado
20
25I
Planeación y Diseño de la Investigación en Ciencias FarmacéuticasPosgrado
21
25I
Seminario de Avances de Investigación IPosgrado
22
25I
Trabajo de Investigación IPosgrado
23
25I
Trabajo de Investigación VIII Posgrado
24
25I
Trabajo de Redacción de Tesis IPosgrado
25
24O
Síntesis y Reactividad de los Compuestos OrgánicosLicenciatura
26
24O
Trabajo de Redacción de Tesis IIIPosgrado
27
24O
Trabajo de Investigación IXPosgrado
28
24O
Trabajo de Investigación VIIPosgrado
29
24O
Seminario de Investigación IIPosgrado
30
24O
Temas Selectos de Diseño, Obtención y Evaluación de Fármacos y BiomoléculasPosgrado
31
24O
Seminario de Avances de Investigación VIIPosgrado
32
24P
Obtención de Compuestos Orgánicos de Interés FarmacéuticoLicenciatura
33
24P
Seminario de Investigación IPosgrado
34
24P
Seminario de Avances de Investigación VIPosgrado
35
24P
Trabajo de Investigación VIPosgrado
36
24P
Trabajo de Investigación VIII Posgrado
37
24P
Trabajo de Redacción de Tesis IIPosgrado
38
24I
Trabajo de Redacción de Tesis IPosgrado
39
24I
Trabajo de Investigación VIIPosgrado
40
24I
Trabajo de Investigación VPosgrado
41
24I
Seminario de Avances de Investigación VPosgrado
42
24I
Planeación y Diseño de la Investigación en Ciencias FarmacéuticasPosgrado
43
24I
Temas Selectos IIPosgrado
44
24I
Obtención de Compuestos Orgánicos de Interés FarmacéuticoLicenciatura
45
23O
Trabajo de Investigación IXPosgrado
46
23O
Trabajo de Investigación VIPosgrado
47
23O
Temas Selectos de Diseño, Obtención y Evaluación de Fármacos y BiomoléculasPosgrado
48
23O
Trabajo de Investigación IVPosgrado
49
23O
Seminario de Avances de Investigación IVPosgrado
50
23O
Seminario VIIPosgrado
51
23O
Obtención de Compuestos Orgánicos de Interés FarmacéuticoLicenciatura
52
23O
Seminario de Avances de Investigación VIPosgrado
53
23P
Obtención y Evaluación de Moléculas con Actividad Biológica y Aplicación TerapéuticaPosgrado
54
23P
Trabajo de Investigación VPosgrado
55
23P
Trabajo de Investigación IIIPosgrado
56
23P
Seminario de Avances de Investigación VPosgrado
57
23P
Seminario de Avances de Investigación IIIPosgrado
58
23P
Proyecto de Investigación IIIPosgrado
59
23P
Proyecto de Investigación IIIPosgrado
60
23P
Trabajo de Investigación VIIIPosgrado
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Universidad Autónoma Metropolitana, 2026.