Academic Work

• ORCID
• ResearchGate
• Scopus

Sustainable Development Goals

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Profile

Professor Ernesto Soto Reyes completed his doctoral studies in Biomedical Sciences at the Universidad Nacional Autónoma de México (UNAM). He was a researcher in Medical Sciences at the National Cancer Institute from 2010-2018.

Since 2018, he has been a Professor at the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus.

His main line of research is cancer epigenetics. He studies the different molecular processes such as DNA methylation profiles, histone post-translational modifications and non-coding RNAs involved in the deregulation of tumor suppressor genes and oncogenes in different cellular models.

He is currently focused on studying epigenetic master regulators such as CTCF, BORIS and histone demethylase KDM4A in different diseases such as cancer.

Information provided by the academic staff

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Academic Work

On the following pages you can consult the research work:

• ResearchGate

See publications

• Scopus

See publications

• ORCID

See publications

Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
OA	Ruiz-Pérez, S., Alcaraz, N., Torres-Arciga, K. and 6 more (...) (2025).Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum). Advanced Biology,9(10)
OA	Flores-Fortis, M., Perez-Añorve, I.X., Patiño-Morales, C.C. and 6 more (...) (2025).Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy. Clinical and Translational Oncology,	\| 3 \|
OA	de la Torre Guzmán, S.R., Pelayo-Chávez, B., García-Muro, A.M. and 2 more (...) (2025).The Role of Folic Acid in DNA Methylation and Breast Cancer. International Journal for Vitamin and Nutrition Research,95(2)	\| 3 \|
OA	Del Moral-Morales, A., Sámano, C., Ocampo-Cervantes, J.A. and 6 more (...) (2024).Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights From Aged and Juvenile Limbs. Scientifica,2024(1)
OA	Perez-Añorve, I.X., Flores-Fortis, M., Patiño-Morales, C.C. and 10 more (...) (2024).Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer. Advanced Therapeutics,7(7)	\| 3 \|
OA	Del Moral-Morales, A., Salgado-Albarrán, M., Sánchez-Pérez, Y. and 3 more (...) (2023).CTCF and Its Multi-Partner Network for Chromatin Regulation. Cells,12(10)
	Morales-Bárcenas, R., Sánchez-Pérez, Y., Santibáñez-Andrade, M. and 3 more (...) (2023).Airborne particulate matter (PM10) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells. Molecular Biology Reports,50(1) 107-119	\| 3 \|
	Carlos-Escalante, J.A., Mejía-Pérez, S.I., Soto-Reyes, E. and 23 more (...) (2023).Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker. Journal of Neuro-Oncology,161(1) 165-174	\| 3 \|
OA	del Moral-Morales, A., Salgado-Albarrán, M., Ortiz-Gutiérrez, E. and 2 more (...) (2022).Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer. Frontiers in Genetics,13	\| 3 \|
OA	Pérez-Aldana, B.E., Martínez-Magaña, J.J., Mayén-Lobo, Y.G. and 12 more (...) (2022).Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers in Psychiatry,13
OA	Salgado-Albarrán, M., Späth, J., González-Barrios, R. and 2 more (...) (2022).CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy. npj Systems Biology and Applications,8(1)	\| 3 \|
	Navarro-Delgado, E.I., Salgado-Albarrán, M., Torres-Arciga, K. and 4 more (...) (2021).Bioinformatics of transcription factor binding prediction. Bioinformatics and Human Genomics Research,203-221
OA	Mayén-Lobo, Y.G., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 7 more (...) (2021).Integrative genomic–epigenomic analysis of clozapine-treated patients with refractory psychosis. Pharmaceuticals,14(2) 1-16
OA	Sámano, C., González-Barrios, R., Castro-Azpíroz, M. and 4 more (...) (2021).Genomics and epigenomics of axolotl regeneration. International Journal of Developmental Biology,52
	Ramirez-Mejia, G., Gil-Lievana, E., Urrego-Morales, O. and 2 more (...) (2021).Class I HDAC inhibition improves object recognition memory consolidation through BDNF/TrkB pathway in a time-dependent manner. Neuropharmacology,187
OA	Carlos-Escalante, J.A., Gómez-Flores-Ramos, L., Bian, X. and 23 more (...) (2021).Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma. Cellular and Molecular Neurobiology,41(6) 1285-1297	\| 3 \|
OA	Salgado-Albarrán, M., Navarro-Delgado, E.I., Del Moral-Morales, A. and 4 more (...) (2021).Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. npj Systems Biology and Applications,7(1)	\| 3 \|
OA	Meléndez-Ramírez, C., Cuevas-Diaz Duran, R., Barrios-García, T. and 7 more (...) (2021).Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons. Scientific Reports,11(1)	\| 3 \|
OA	Quintas-Granados, L.I., Cortés, H., Carmen, M.G.-D. and 11 more (...) (2021).The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. Cancer Cell International,21(1)	\| 3 \|
OA	Patiño-Morales, C.C., Soto-Reyes, E., Arechaga-Ocampo, E. and 4 more (...) (2020).Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines. Redox Biology,28	\| 3 \|
OA	García-Cuellar, C.M., Chirino, Y.I., Morales-Bárcenas, R. and 4 more (...) (2020).Airborne particulate matter (PM10) inhibits apoptosis through PI3K/AKT/FoxO3a pathway in lung epithelial cells: The role of a second oxidant stimulus. International Journal of Molecular Sciences,21(2)	\| 3 \|

Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	25O	Proyecto Terminal I	Licenciatura
2	25O	Proyecto Terminal I	Licenciatura
3	25O	Biología Celular II	Licenciatura
4	25O	Seminario II	Posgrado
5	25O	Seminario II	Posgrado
6	25O	Seminario II	Posgrado
7	25O	Seminario II	Posgrado
8	25O	Seminario II	Posgrado
9	25O	Proyecto de Investigación II	Posgrado
10	25O	Proyecto de Investigación II	Posgrado
11	25O	Proyecto de Investigación II	Posgrado
12	25O	Proyecto de Investigación II	Posgrado
13	25O	Proyecto de Investigación II	Posgrado
14	25O	Trabajo de Investigación VII	Posgrado
15	25P	Introducción a la Biología Molecular	Licenciatura
16	25P	Técnicas de Biología Molecular III	Licenciatura
17	25P	Proyecto Terminal II	Licenciatura
18	25P	Proyecto Terminal III	Licenciatura
19	25P	Seminario VI	Posgrado
20	25P	Trabajo de Investigación VI	Posgrado
21	25P	Proyecto de Investigación I	Posgrado
22	25P	Proyecto de Investigación I	Posgrado
23	25P	Proyecto de Investigación I	Posgrado
24	25P	Proyecto de Investigación I	Posgrado
25	25P	Proyecto de Investigación I	Posgrado
26	25P	Temas Selectos II	Posgrado
27	25I	Técnicas de Biología Molecular II	Licenciatura
28	25I	Proyecto Terminal I	Licenciatura
29	25I	Proyecto Terminal II	Licenciatura
30	25I	Proyecto Terminal III	Licenciatura
31	25I	Biología Celular II	Licenciatura
32	25I	Seminario I	Posgrado
33	25I	Seminario I	Posgrado
34	25I	Seminario I	Posgrado
35	25I	Seminario I	Posgrado
36	25I	Seminario I	Posgrado
37	25I	Seminario V	Posgrado
38	25I	Trabajo de Investigación V	Posgrado
39	24O	Proyecto Terminal II	Licenciatura
40	24O	Temas Selectos en Biología Molecular I	Licenciatura
41	24O	Temas Selectos en Biología Molecular II	Licenciatura
42	24O	Proyecto Terminal I	Licenciatura
43	24O	Tópicos Selectos Interdisciplinarios V	Licenciatura
44	24O	Seminario IV	Posgrado
45	24O	Trabajo de Investigación IV	Posgrado
46	24P	Técnicas de Biología Molecular III	Licenciatura
47	24P	Proyecto Terminal I	Licenciatura
48	24P	Proyecto Terminal II	Licenciatura
49	24P	Proyecto Terminal III	Licenciatura
50	24P	Seminario III	Posgrado
51	24P	Seminario III	Posgrado
52	24P	Trabajo de Investigación III	Posgrado
53	24I	Temas Selectos en Biología Molecular I	Licenciatura
54	24I	Temas Selectos en Biología Molecular II	Licenciatura
55	24I	Técnicas de Biología Molecular II	Licenciatura
56	24I	Proyecto Terminal I	Licenciatura
57	24I	Proyecto Terminal I	Licenciatura
58	24I	Proyecto Terminal III	Licenciatura
59	24I	Proyecto Terminal III	Licenciatura
60	24I	Seminario II	Posgrado

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