Academic Work

• ORCID
• ResearchGate
• Scopus

Sustainable Development Goals

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Profile

Professor Ernesto Soto Reyes completed his doctoral studies in Biomedical Sciences at the Universidad Nacional Autónoma de México (UNAM). He was a researcher in Medical Sciences at the National Cancer Institute from 2010-2018.

Since 2018, he has been a Professor at the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus.

His main line of research is cancer epigenetics. He studies the different molecular processes such as DNA methylation profiles, histone post-translational modifications and non-coding RNAs involved in the deregulation of tumor suppressor genes and oncogenes in different cellular models.

He is currently focused on studying epigenetic master regulators such as CTCF, BORIS and histone demethylase KDM4A in different diseases such as cancer.

Information provided by the academic staff

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Academic Work

On the following pages you can consult the research work:

• ResearchGate

See publications

• Scopus

See publications

• ORCID

See publications

Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
OA	Ramírez-Mejía, G., Plata-Burgos, S., Cuevas-Díaz Duran, R. and 4 more (...) (2026).BORIS/CTCFL Reprograms Glioblastoma Transcriptional Networks through the Regulation of Tumor-Associated Genes such as CD36 and FBN2. Biocell,50(3)	\| 3 \|
OA	Ávila-Galicia, K.E., Alarcón-Aguilar, A., Soto-Reyes, E. and 1 more (...) (2026).Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload. Ageing Research Reviews,118	\| 3 \|
OA	Flores-Fortis, M., Perez-Añorve, I.X., Patiño-Morales, C.C. and 6 more (...) (2026).Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy. Clinical and Translational Oncology,28(4) 1285-1302	\| 3 \|
OA	Ruiz-Pérez, S., Alcaraz, N., Torres-Arciga, K. and 6 more (...) (2025).Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum). Advanced Biology,9(10)
OA	de la Torre Guzmán, S.R., Pelayo-Chávez, B., García-Muro, A.M. and 2 more (...) (2025).The Role of Folic Acid in DNA Methylation and Breast Cancer. International Journal for Vitamin and Nutrition Research,95(2)	\| 3 \|
OA	Perez-Añorve, I.X., Flores-Fortis, M., Patiño-Morales, C.C. and 10 more (...) (2024).Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer. Advanced Therapeutics,7(7)	\| 3 \|
OA	Del Moral-Morales, A., Sámano, C., Ocampo-Cervantes, J.A. and 6 more (...) (2024).Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights From Aged and Juvenile Limbs. Scientifica,2024(1)
	Carlos-Escalante, J.A., Mejía-Pérez, S.I., Soto-Reyes, E. and 23 more (...) (2023).Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker. Journal of Neuro-Oncology,161(1) 165-174	\| 3 \|
OA	Del Moral-Morales, A., Salgado-Albarrán, M., Sánchez-Pérez, Y. and 3 more (...) (2023).CTCF and Its Multi-Partner Network for Chromatin Regulation. Cells,12(10)
	Morales-Bárcenas, R., Sánchez-Pérez, Y., Santibáñez-Andrade, M. and 3 more (...) (2023).Airborne particulate matter (PM10) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells. Molecular Biology Reports,50(1) 107-119	\| 3 \|
OA	Salgado-Albarrán, M., Späth, J., González-Barrios, R. and 2 more (...) (2022).CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy. npj Systems Biology and Applications,8(1)	\| 3 \|
OA	del Moral-Morales, A., Salgado-Albarrán, M., Ortiz-Gutiérrez, E. and 2 more (...) (2022).Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer. Frontiers in Genetics,13	\| 3 \|
OA	Pérez-Aldana, B.E., Martínez-Magaña, J.J., Mayén-Lobo, Y.G. and 12 more (...) (2022).Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers in Psychiatry,13
OA	Carlos-Escalante, J.A., Gómez-Flores-Ramos, L., Bian, X. and 23 more (...) (2021).Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma. Cellular and Molecular Neurobiology,41(6) 1285-1297	\| 3 \|
OA	Quintas-Granados, L.I., Cortés, H., Carmen, M.G.-D. and 11 more (...) (2021).The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. Cancer Cell International,21(1)	\| 3 \|
OA	Meléndez-Ramírez, C., Cuevas-Diaz Duran, R., Barrios-García, T. and 7 more (...) (2021).Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons. Scientific Reports,11(1)
OA	Mayén-Lobo, Y.G., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 7 more (...) (2021).Integrative genomic–epigenomic analysis of clozapine-treated patients with refractory psychosis. Pharmaceuticals,14(2) 1-16
OA	Salgado-Albarrán, M., Navarro-Delgado, E.I., Del Moral-Morales, A. and 4 more (...) (2021).Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. npj Systems Biology and Applications,7(1)	\| 3 \|
OA	Sámano, C., González-Barrios, R., Castro-Azpíroz, M. and 4 more (...) (2021).Genomics and epigenomics of axolotl regeneration. International Journal of Developmental Biology,52
	Navarro-Delgado, E.I., Salgado-Albarrán, M., Torres-Arciga, K. and 4 more (...) (2021).Bioinformatics of transcription factor binding prediction. Bioinformatics and Human Genomics Research,203-221
	Ramirez-Mejia, G., Gil-Lievana, E., Urrego-Morales, O. and 2 more (...) (2021).Class I HDAC inhibition improves object recognition memory consolidation through BDNF/TrkB pathway in a time-dependent manner. Neuropharmacology,187
OA	Patiño-Morales, C.C., Soto-Reyes, E., Arechaga-Ocampo, E. and 4 more (...) (2020).Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines. Redox Biology,28	\| 3 \|
OA	García-Cuellar, C.M., Chirino, Y.I., Morales-Bárcenas, R. and 4 more (...) (2020).Airborne particulate matter (PM10) inhibits apoptosis through PI3K/AKT/FoxO3a pathway in lung epithelial cells: The role of a second oxidant stimulus. International Journal of Molecular Sciences,21(2)	\| 3 \|

Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	26I	Proyecto de Investigación III	Posgrado
2	26I	Proyecto de Investigación III	Posgrado
3	26I	Proyecto de Investigación III	Posgrado
4	26I	Proyecto de Investigación III	Posgrado
5	26I	Proyecto de Investigación III	Posgrado
6	26I	Proyecto Terminal I	Licenciatura
7	26I	Proyecto Terminal II	Licenciatura
8	26I	Proyecto Terminal II	Licenciatura
9	26I	Técnicas de Biología Molecular II	Licenciatura
10	26I	Trabajo de Investigación VIII	Posgrado
11	25O	Biología Celular II	Licenciatura
12	25O	Proyecto de Investigación II	Posgrado
13	25O	Proyecto de Investigación II	Posgrado
14	25O	Proyecto de Investigación II	Posgrado
15	25O	Proyecto de Investigación II	Posgrado
16	25O	Proyecto de Investigación II	Posgrado
17	25O	Proyecto Terminal I	Licenciatura
18	25O	Proyecto Terminal I	Licenciatura
19	25O	Seminario II	Posgrado
20	25O	Seminario II	Posgrado
21	25O	Seminario II	Posgrado
22	25O	Seminario II	Posgrado
23	25O	Seminario II	Posgrado
24	25O	Trabajo de Investigación VII	Posgrado
25	25P	Introducción a la Biología Molecular	Licenciatura
26	25P	Proyecto de Investigación I	Posgrado
27	25P	Proyecto de Investigación I	Posgrado
28	25P	Proyecto de Investigación I	Posgrado
29	25P	Proyecto de Investigación I	Posgrado
30	25P	Proyecto de Investigación I	Posgrado
31	25P	Proyecto Terminal II	Licenciatura
32	25P	Proyecto Terminal III	Licenciatura
33	25P	Seminario VI	Posgrado
34	25P	Técnicas de Biología Molecular III	Licenciatura
35	25P	Temas Selectos II	Posgrado
36	25P	Trabajo de Investigación VI	Posgrado
37	25I	Biología Celular II	Licenciatura
38	25I	Proyecto Terminal I	Licenciatura
39	25I	Proyecto Terminal II	Licenciatura
40	25I	Proyecto Terminal III	Licenciatura
41	25I	Seminario I	Posgrado
42	25I	Seminario I	Posgrado
43	25I	Seminario I	Posgrado
44	25I	Seminario I	Posgrado
45	25I	Seminario I	Posgrado
46	25I	Seminario V	Posgrado
47	25I	Técnicas de Biología Molecular II	Licenciatura
48	25I	Trabajo de Investigación V	Posgrado
49	24O	Proyecto Terminal I	Licenciatura
50	24O	Proyecto Terminal II	Licenciatura
51	24O	Seminario IV	Posgrado
52	24O	Temas Selectos en Biología Molecular I	Licenciatura
53	24O	Temas Selectos en Biología Molecular II	Licenciatura
54	24O	Tópicos Selectos Interdisciplinarios V	Licenciatura
55	24O	Trabajo de Investigación IV	Posgrado
56	24P	Proyecto Terminal I	Licenciatura
57	24P	Proyecto Terminal II	Licenciatura
58	24P	Proyecto Terminal III	Licenciatura
59	24P	Seminario III	Posgrado
60	24P	Seminario III	Posgrado

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