Academic Work

• ORCID
• ResearchGate
• Scopus

Sustainable Development Goals

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Profile

Professor Ernesto Soto Reyes completed his doctoral studies in Biomedical Sciences at the Universidad Nacional Autónoma de México (UNAM). He was a researcher in Medical Sciences at the National Cancer Institute from 2010-2018.

Since 2018, he has been a Professor at the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus.

His main line of research is cancer epigenetics. He studies the different molecular processes such as DNA methylation profiles, histone post-translational modifications and non-coding RNAs involved in the deregulation of tumor suppressor genes and oncogenes in different cellular models.

He is currently focused on studying epigenetic master regulators such as CTCF, BORIS and histone demethylase KDM4A in different diseases such as cancer.

Information provided by the academic staff

Research interests

• Epigenetics
• Cancer
• Proteins CTCF and BORIS
• Histone Demethylases
• Inhibitors and epidrugs
• Tissue regeneration in axolotl (Ambystoma mexicanum)

Academic Work

On the following pages you can consult the research work:

• ResearchGate

See publications

• Scopus

See publications

• ORCID

See publications

Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
OA	Ávila-Galicia, K.E., Alarcón-Aguilar, A., Soto-Reyes, E. and 1 more (...) (2026).Epigenetic remodeling induced by fatty acids: Chromatin modifications and cellular senescence during lipid overload. Ageing Research Reviews,118	3
OA	Ramírez-Mejía, G., Plata-Burgos, S., Cuevas-Díaz Duran, R. and 4 more (...) (2026).BORIS/CTCFL Reprograms Glioblastoma Transcriptional Networks through the Regulation of Tumor-Associated Genes such as CD36 and FBN2. Biocell,50(3)	3
OA	Flores-Fortis, M., Perez-Añorve, I.X., Patiño-Morales, C.C. and 6 more (...) (2026).Loss of miR-122 promotes cell migration and poor prognosis in triple-negative breast cancer treated by neoadjuvant chemotherapy. Clinical and Translational Oncology,28(4) 1285-1302	3
OA	de la Torre Guzmán, S.R., Pelayo-Chávez, B., García-Muro, A.M. and 2 more (...) (2025).The Role of Folic Acid in DNA Methylation and Breast Cancer. International Journal for Vitamin and Nutrition Research,95(2)	3
OA	Ruiz-Pérez, S., Alcaraz, N., Torres-Arciga, K. and 6 more (...) (2025).Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum). Advanced Biology,9(10)
OA	Del Moral-Morales, A., Sámano, C., Ocampo-Cervantes, J.A. and 6 more (...) (2024).Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights From Aged and Juvenile Limbs. Scientifica,2024(1)
OA	Perez-Añorve, I.X., Flores-Fortis, M., Patiño-Morales, C.C. and 10 more (...) (2024).Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer. Advanced Therapeutics,7(7)	3
OA	Del Moral-Morales, A., Salgado-Albarrán, M., Sánchez-Pérez, Y. and 3 more (...) (2023).CTCF and Its Multi-Partner Network for Chromatin Regulation. Cells,12(10)
	Morales-Bárcenas, R., Sánchez-Pérez, Y., Santibáñez-Andrade, M. and 3 more (...) (2023).Airborne particulate matter (PM10) induces cell invasion through Aryl Hydrocarbon Receptor and Activator Protein 1 (AP-1) pathway deregulation in A549 lung epithelial cells. Molecular Biology Reports,50(1) 107-119	3
	Carlos-Escalante, J.A., Mejía-Pérez, S.I., Soto-Reyes, E. and 23 more (...) (2023).Deep DNA sequencing of MGMT, TP53 and AGT in Mexican astrocytoma patients identifies an excess of genetic variants in women and a predictive biomarker. Journal of Neuro-Oncology,161(1) 165-174	3
OA	Salgado-Albarrán, M., Späth, J., González-Barrios, R. and 2 more (...) (2022).CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapy. npj Systems Biology and Applications,8(1)	3
OA	del Moral-Morales, A., Salgado-Albarrán, M., Ortiz-Gutiérrez, E. and 2 more (...) (2022).Transcriptomic and Drug Discovery Analyses Reveal Natural Compounds Targeting the KDM4 Subfamily as Promising Adjuvant Treatments in Cancer. Frontiers in Genetics,13	3
OA	Pérez-Aldana, B.E., Martínez-Magaña, J.J., Mayén-Lobo, Y.G. and 12 more (...) (2022).Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers in Psychiatry,13
OA	Sámano, C., González-Barrios, R., Castro-Azpíroz, M. and 4 more (...) (2021).Genomics and epigenomics of axolotl regeneration. International Journal of Developmental Biology,52
OA	Salgado-Albarrán, M., Navarro-Delgado, E.I., Del Moral-Morales, A. and 4 more (...) (2021).Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. npj Systems Biology and Applications,7(1)	3
OA	Mayén-Lobo, Y.G., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 7 more (...) (2021).Integrative genomic–epigenomic analysis of clozapine-treated patients with refractory psychosis. Pharmaceuticals,14(2) 1-16
OA	Meléndez-Ramírez, C., Cuevas-Diaz Duran, R., Barrios-García, T. and 7 more (...) (2021).Dynamic landscape of chromatin accessibility and transcriptomic changes during differentiation of human embryonic stem cells into dopaminergic neurons. Scientific Reports,11(1)
OA	Quintas-Granados, L.I., Cortés, H., Carmen, M.G.-D. and 11 more (...) (2021).The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. Cancer Cell International,21(1)	3
OA	Carlos-Escalante, J.A., Gómez-Flores-Ramos, L., Bian, X. and 23 more (...) (2021).Landscape of Germline Genetic Variants in AGT, MGMT, and TP53 in Mexican Adult Patients with Astrocytoma. Cellular and Molecular Neurobiology,41(6) 1285-1297	3
	Ramirez-Mejia, G., Gil-Lievana, E., Urrego-Morales, O. and 2 more (...) (2021).Class I HDAC inhibition improves object recognition memory consolidation through BDNF/TrkB pathway in a time-dependent manner. Neuropharmacology,187
	Navarro-Delgado, E.I., Salgado-Albarrán, M., Torres-Arciga, K. and 4 more (...) (2021).Bioinformatics of transcription factor binding prediction. Bioinformatics and Human Genomics Research,203-221
OA	Patiño-Morales, C.C., Soto-Reyes, E., Arechaga-Ocampo, E. and 4 more (...) (2020).Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines. Redox Biology,28	3
OA	García-Cuellar, C.M., Chirino, Y.I., Morales-Bárcenas, R. and 4 more (...) (2020).Airborne particulate matter (PM10) inhibits apoptosis through PI3K/AKT/FoxO3a pathway in lung epithelial cells: The role of a second oxidant stimulus. International Journal of Molecular Sciences,21(2)	3

Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	26P	Seminario VII	Posgrado
2	26P	Trabajo de Investigación IX	Posgrado
3	26P	Temas Selectos IV	Posgrado
4	26P	Seminario III	Posgrado
5	26P	Seminario III	Posgrado
6	26P	Seminario III	Posgrado
7	26P	Seminario III	Posgrado
8	26P	Seminario III	Posgrado
9	26P	Proyecto Terminal III	Licenciatura
10	26P	Proyecto Terminal III	Licenciatura
11	26P	Proyecto Terminal I	Licenciatura
12	26P	Técnicas de Biología Molecular III	Licenciatura
13	26P	Temas Selectos en Biología Molecular II	Licenciatura
14	26P	Temas Selectos en Biología Molecular I	Licenciatura
15	26I	Proyecto de Investigación III	Posgrado
16	26I	Proyecto de Investigación III	Posgrado
17	26I	Proyecto de Investigación III	Posgrado
18	26I	Proyecto de Investigación III	Posgrado
19	26I	Proyecto de Investigación III	Posgrado
20	26I	Proyecto Terminal I	Licenciatura
21	26I	Proyecto Terminal II	Licenciatura
22	26I	Proyecto Terminal II	Licenciatura
23	26I	Técnicas de Biología Molecular II	Licenciatura
24	26I	Trabajo de Investigación VIII	Posgrado
25	25O	Proyecto Terminal I	Licenciatura
26	25O	Biología Celular II	Licenciatura
27	25O	Proyecto de Investigación II	Posgrado
28	25O	Proyecto de Investigación II	Posgrado
29	25O	Proyecto de Investigación II	Posgrado
30	25O	Proyecto de Investigación II	Posgrado
31	25O	Proyecto de Investigación II	Posgrado
32	25O	Proyecto Terminal I	Licenciatura
33	25O	Seminario II	Posgrado
34	25O	Seminario II	Posgrado
35	25O	Seminario II	Posgrado
36	25O	Seminario II	Posgrado
37	25O	Seminario II	Posgrado
38	25O	Trabajo de Investigación VII	Posgrado
39	25P	Proyecto Terminal III	Licenciatura
40	25P	Introducción a la Biología Molecular	Licenciatura
41	25P	Proyecto de Investigación I	Posgrado
42	25P	Proyecto de Investigación I	Posgrado
43	25P	Proyecto de Investigación I	Posgrado
44	25P	Proyecto de Investigación I	Posgrado
45	25P	Proyecto de Investigación I	Posgrado
46	25P	Proyecto Terminal II	Licenciatura
47	25P	Seminario VI	Posgrado
48	25P	Técnicas de Biología Molecular III	Licenciatura
49	25P	Temas Selectos II	Posgrado
50	25P	Trabajo de Investigación VI	Posgrado
51	25I	Seminario I	Posgrado
52	25I	Técnicas de Biología Molecular II	Licenciatura
53	25I	Seminario I	Posgrado
54	25I	Seminario I	Posgrado
55	25I	Seminario I	Posgrado
56	25I	Proyecto Terminal II	Licenciatura
57	25I	Biología Celular II	Licenciatura
58	25I	Proyecto Terminal I	Licenciatura
59	25I	Seminario I	Posgrado
60	25I	Proyecto Terminal III	Licenciatura

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