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Perfil investigador
Esp
Dr. Alejandro Islas Jacome

Professor
Departament of Chemistry

Division of Basic Sciences and Engineering


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Iztapalapa Campus

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Academic Group



Sustainable Development Goals

• 3 Good Health and Well-Being

• 4 Quality Education

• 9 Industry, Innovation, and Infrastructure


Research interests

• Synthesis of Polyheterocycles via Multicomponent Reactions
• Drug synthesis
• Synthesis of ligands to assemble new MOFs
• Click reactions

Profile

Dr. Alejandro Islas Jácome got the Bs (Chemistry) in 2006 and PhD (Chemistry) in 2011, both under the guidance of Professor Eduardo González Zamora at UAM, awarded medal for university merit on both occasions.

Subsequently, he was a postdoctoral fellow from 2012 to 2016 at the University of Guanajuato under the advice of Dra. Rocío Gámez Montaño. Later, in 2017, he joined the Department of Chemistry at UAM as a Visiting Professor; and, finally, in 2020 he joined for an indefinite period the academic staff of the same Department as Full-Time Titular Professor "C".

Dr. Islas belongs to the SNII CONAHCyT level 2 and has the desirable PRODEP profile. His areas of specialty are Organic Synthesis and Pharmaco-chemistry. In this context, his lines of research include the synthesis of polyheterocycles via Multicomponent Reactions (MCRs), drug synthesis, synthesis of ligands to assemble new MOFs and click reactions. This has allowed him to publish 51 articles in journals indexed in the Journal of Citation Reports (JCR), in addition to 15 international proceedings.

In 2018 he obtained the diploma for research in the Basic Sciences and Engineering area. Dr. Islas has directed 18 terminal projects with a specialty in organic chemistry, 10 social services and has graduated 1 master's thesis student. He currently directs 2 social services, 1 bachelor's terminal project, 2 master's theses and 2 doctoral thesis. Likewise, it is worth highlighting that he serves as Academic Coordinator of the DCBI Chemistry Teaching Laboratories at the UAM.



Information provided by the academic staff

Research interests

• Synthesis of Polyheterocycles via Multicomponent Reactions
• Drug synthesis
• Synthesis of ligands to assemble new MOFs
• Click reactions

Academic Work

On the following pages you can consult the research work:




Academic Group

Consult the information provided by the Academic Group




Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAFlores-Reyes, J.C., Cotlame-Salinas, V.D.C., Ibarra, I.A. and 2 more (...) (2023).Pseudo-multicomponent reactions. RSC Advances,13(24) 16091-16125
Aguilar-Morales, C.M., Servín-García, G., del Río, R.E. and 4 more (...) (2023).Synthesis of novel hybrid 1,5-disusbtituted 1H-tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5-a]pyrazin-6-ones via high-order MCR-SN 2/intramolecular [3 + 2] cycloaddition sequence. Synthetic Communications,53(2) 127-134
OAFlores, J.G., Obeso, J.L., Martínez-Jiménez, V. and 11 more (...) (2023).Evaluation of the catalytic activity of Zn-MOF-74 for the alcoholysis of cyclohexene oxide. RSC Advances,13(39) 27174-27179
OAMorales-Salazar, I., Garduño-Albino, C.E., Montes-Enríquez, F.P. and 5 more (...) (2023).Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma. Pharmaceuticals,16(11) | 3 |
OABlanco-Carapia, R.E., Aguilar-Rangel, E.A., Rincón-Guevara, M.A. and 2 more (...) (2023).Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy. Molecules,28(10)
OAIslas-Jácome, P., García-Falcón, C., Castañón-Alonso, S.L. and 4 more (...) (2023).2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one. MolBank,2023(3)
Servín-García, G., Chacón-García, L., Islas-Jácome, A. and 4 more (...) (2023).Late-stage functionalization of Vouacapane derivatives from Caesalpinia platyloba by a Groebke−Blackburn−Bienaymé reaction. Journal of Heterocyclic Chemistry,60(11) 1903-1910
López-Cervantes, V.B., Obeso, J.L., Yañez-Aulestia, A. and 5 more (...) (2023).MFM-300(Sc): a chemically stable Sc(iii)-based MOF material for multiple applications. Chemical Communications,59(69) 10343-10359
OAMorales-Salazar, I., Rincón-Guevara, M.A., González-Zamora, E. and 1 more (...) (2022).2-Benzyl-3-morpholino-7-(thiophen-2-yl)-6-(thiophen-2-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one. MolBank,2022(4)
Obeso, J.L., López-Olvera, A., Flores, C.V. and 11 more (...) (2022).Methylene blue adsorption in DUT-5: Relatively strong host-guest interactions elucidated by FTIR, solid-state NMR, and XPS. Journal of Molecular Liquids,368
Niño-Pantoja, I., Gallardo-Alfonzo, A., Solis-Santos, M. and 5 more (...) (2022).Synthesis of 1,5-Disubstituted Tetrazole−Indolizine Bis-Heterocycles and Their Copper (II) Recognizing Properties. European Journal of Organic Chemistry,2022(34)
OABlanco-Carapia, R.E., Aguilar-Rangel, E.A., Islas-Jácome, A. and 1 more (...) (2022).Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine). MolBank,2022(3)
Morales-Salazar, I., Montes-Enríquez, F.P., Garduño-Albino, C.E. and 9 more (...) (2022).Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins. RSC Medicinal Chemistry,14(1) 154-165| 3 |
OAAguilar-Morales, C.M., Araujo-Huitrado, J.G., López-Hernández, Y. and 7 more (...) (2021).A one-pot six-component reaction for the synthesis of 1,5-disubstituted tetrazol-1,2,3-triazole hybrids and their cytotoxic activity against the mcf-7 cell line. Molecules,26(20) | 3 |
Flores-Reyes, J.C., Islas-Jácome, A., González-Zamora, E. (2021).The Ugi three-component reaction and its variants. Organic Chemistry Frontiers,8(19) 5460-5515
OACotlame-Salinas, V.D.C., López-Olvera, A., Islas-Jácome, A. and 2 more (...) (2021).CO2capture enhancement in MOFs: Via the confinement of molecules. Reaction Chemistry and Engineering,6(3) 441-453| 13 |
OAAlmaraz-Girón, M.A., Calderón-Jaimes, E., Carrillo, A.S. and 5 more (...) (2021).Search for non-protein protease inhibitors constituted with an indole and acetylene core. Molecules,26(13) | 3 |
OASánchez-González, E., Flores, J.G., Flores-Reyes, J.C. and 7 more (...) (2020).Bottleneck effect explained by Le Bail Refinements: Structure transformation of Mg-CUK-1 by confining H2O molecules. Materials,13(8) | 13 |
OACastañón-Alonso, S.L., Morales-Saavedra, O.G., Almaraz-Girón, M.A. and 7 more (...) (2020).Quadratic non-linear optical properties of the poly(2,5-bis(but-2-ynyloxy) benzoate containing the 2-(ethyl(4-(4-nitrophenyl)buta-1,3-diynyl) phenyl)amino)ethanol) chromophore. Polymers,12(1)
OAAlvarado-Alvarado, D., González-Estefan, J.H., Flores, J.G. and 9 more (...) (2020).Water Adsorption Properties of Fe(pz)[Pt(CN)4] and the Capture of CO2 and CO. Organometallics,39(7) 949-955| 13 |
OASegura-Olvera, D., García-González, A.N., Morales-Salazar, I. and 6 more (...) (2019).Synthesis of pyrrolo[3,4-b]pyridin-5-ones via multicomponent reactions and in vitro–in silico studies against SiHa, HeLa, and CaSki human cervical carcinoma cell lines. Molecules,24(14) | 3 |
Jurado-Vázquez, T., Sánchez-González, E., Campos-Reales-Pineda, A.E. and 4 more (...) (2019).MFM-300: From air pollution remediation to toxic gas detection. Polyhedron,157495-504
OARentería-Gómez, M.A., Islas-Jácome, A., Pharande, S.G. and 2 more (...) (2019).Synthesis of Tris-Heterocycles via a Cascade IMCR/Aza Diels-Alder + CuAAC Strategy. Frontiers in Chemistry,7
OAVázquez-Vera, Ó., Segura-Olvera, D., Rincón-Guevara, M.A. and 6 more (...) (2018).Synthesis of new 5-aryl-benzo[f][1,7]naphthyridines via a cascade process (Ugi-3CR/intramolecular aza-diels-alder cycloaddition)/aromatization. Molecules,23(8)
Ibarra, I.A., Islas-Jácome, A., González-Zamora, E. (2018).Synthesis of polyheterocycles via multicomponent reactions. Organic and Biomolecular Chemistry,16(9) 1402-1418
Alvarez-Rodríguez, N.V., Islas-Jácome, A., Rentería-Gómez, A. and 3 more (...) (2018).Synthesis of 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles]: Via two coupled one-pot processes Ugi-azide/Pictet-Spengler and oxidative spiro-rearrangement. New Journal of Chemistry,42(3) 1600-1603| 3 |
OAZamudio-Medina, A., García-González, A.N., Herrera-Carrillo, G.K. and 6 more (...) (2018).Synthesis of polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a one-pot (Ugi-3CR/aza diels-alder/N-acylation/aromatization/SN2) process. A suitable alternative towards novel Aza-analogues of falipamil. Molecules,23(4)
Basavanag, U.M.V., Islas-Jácome, A., Rentería-Gómez, A. and 6 more (...) (2017).Synthesis of 2-julolidin-imidazo[1,2-a] pyridines via Groebke-Blackburn-Bienaymé reaction and studies of optical properties. New Journal of Chemistry,41(9) 3450-3459
Sánchez-González, E., López-Olvera, A., Monroy, O. and 7 more (...) (2017).Synthesis of vanillin: Via a catalytically active Cu(II)-metal organic polyhedron. CrystEngComm,19(29) 4142-4146
Álvarez, J.R., Sánchez-González, E., Pérez, E. and 6 more (...) (2017).Structure stability of HKUST-1 towards water and ethanol and their effect on its CO2 capture properties. Dalton Transactions,46(28) 9192-9200| 13 |
Vázquez-Vera, Ó., Sánchez-Badillo, J.S., Islas-Jácome, A. and 7 more (...) (2017).An efficient Ugi-3CR/aza Diels-Alder/Pomeranz-Fritsch protocol towards novel aza-analogues of (±)-nuevamine, (±)-lennoxamine and magallanesine: a diversity oriented synthesis approach. Organic and Biomolecular Chemistry,15(11) 2363-2369
Islas-Jácome, A., Rentería-Gómez, A., Rentería-Gómez, M.A. and 3 more (...) (2016).Selective reaction route in the construction of the pyrrolo[3,4-b]pyridin-5-one core from a variety of 5-aminooxazoles and maleic anhydride. A DFT study. Tetrahedron Letters,57(31) 3496-3500
Islas-Jácome, A., Gutiérrez-Carrillo, A., García-Garibay, M.A. and 1 more (...) (2014).One-pot synthesis of nuevamine aza-analogues by combined use of an oxidative Ugi type reaction and aza-diels-alder cycloaddition. Synlett,25(3) 403-406

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Courses offered

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
23O
Proyecto Terminal I Química OrgánicaLicenciatura
2
23O
Química Orgánica IILicenciatura
3
23O
Resonancia MagnéticaPosgrado
4
23O
Trabajo de Investigación VPosgrado
5
23P
Química Orgánica ILicenciatura
6
23P
Síntesis de FármacosLicenciatura
7
23P
Temas Selectos en FarmoquímicaLicenciatura
8
23P
Proyecto Terminal II Química OrgánicaLicenciatura
9
23P
Proyecto Terminal II Química OrgánicaLicenciatura
10
23P
Proyecto Terminal II Química OrgánicaLicenciatura
11
23P
Trabajo de Investigación IVPosgrado
12
23I
Química Orgánica IIILicenciatura
13
23I
Síntesis de FármacosLicenciatura
14
23I
Proyecto Terminal I Química OrgánicaLicenciatura
15
23I
Proyecto Terminal I Química OrgánicaLicenciatura
16
23I
Proyecto Terminal I Química OrgánicaLicenciatura
17
23I
Proyecto Terminal II Química OrgánicaLicenciatura
18
23I
Proyecto Terminal II Química OrgánicaLicenciatura
19
23I
Trabajo de Investigación IIIPosgrado
20
22O
Química Orgánica IILicenciatura
21
22O
Temas Selectos en FarmoquímicaLicenciatura
22
22O
Proyecto Terminal I Química OrgánicaLicenciatura
23
22O
Proyecto Terminal I Química OrgánicaLicenciatura
24
22O
Proyecto Terminal II Química OrgánicaLicenciatura
25
22O
Trabajo de Investigación IIPosgrado
26
22P
Temas Selectos de Procesos QuímicosLicenciatura
27
22P
Proyecto Terminal I Química OrgánicaLicenciatura
28
22P
Proyecto Terminal II Química OrgánicaLicenciatura
29
22P
Proyecto Terminal II Química OrgánicaLicenciatura
30
22P
Proyecto Terminal II Química OrgánicaLicenciatura
31
22P
Proyecto Terminal II Química OrgánicaLicenciatura
32
22P
Proyecto Terminal III Manejo del AguaLicenciatura
33
22P
Química Orgánica ILicenciatura
34
22P
Laboratorio de Química OrgánicaLicenciatura
35
22P
Síntesis de FármacosLicenciatura
36
22P
Trabajo de Investigación IPosgrado
37
22I
Laboratorio de Química OrgánicaLicenciatura
38
22I
Síntesis de FármacosLicenciatura
39
22I
Temas Selectos en FarmoquímicaLicenciatura
40
22I
Proyecto Terminal I Química OrgánicaLicenciatura
41
22I
Proyecto Terminal I Química OrgánicaLicenciatura
42
22I
Proyecto Terminal I Química OrgánicaLicenciatura
43
22I
Proyecto Terminal I Química OrgánicaLicenciatura
44
22I
Temas Selectos de Procesos QuímicosLicenciatura
45
22I
Proyecto Terminal II Manejo del AguaLicenciatura
46
21O
Química Orgánica IIILicenciatura
47
21P
Química Orgánica IILicenciatura
48
21P
Síntesis de FármacosLicenciatura
49
21P
Síntesis TotalPosgrado
50
21I
Química Orgánica ILicenciatura
51
21I
Química Orgánica IILicenciatura
52
21I
Resonancia MagnéticaPosgrado
53
21I
Temas Selectos de Biotecnología IIPosgrado
54
20O
Química Orgánica IIILicenciatura
55
20O
Síntesis de FármacosLicenciatura
56
20O
Síntesis TotalPosgrado
57
20P
Química Orgánica IILicenciatura
58
20P
Resonancia MagnéticaPosgrado
59
20I
Química Orgánica ILicenciatura
60
20I
Química de Radicales LibresPosgrado
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Universidad Autónoma Metropolitana, 2024.