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Perfil investigador
Esp
Dr. Alejandro Islas Jacome

Professor
Departament of Chemistry

Division of Basic Sciences and Engineering


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Iztapalapa Campus

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Sustainable Development Goals

• 3 Good Health and Well-Being

• 4 Quality Education

• 9 Industry, Innovation, and Infrastructure


Research interests

• Synthesis of Polyheterocycles via Multicomponent Reactions
• Drug synthesis
• Synthesis of ligands to assemble new MOFs
• Click reactions

Profile

Dr. Alejandro Islas Jácome got the Bs (Chemistry) in 2006 and PhD (Chemistry) in 2011, both under the guidance of Professor Eduardo González Zamora at UAM, awarded medal for university merit on both occasions.

Subsequently, he was a postdoctoral fellow from 2012 to 2016 at the University of Guanajuato under the advice of Dra. Rocío Gámez Montaño. Later, in 2017, he joined the Department of Chemistry at UAM as a Visiting Professor; and, finally, in 2020 he joined for an indefinite period the academic staff of the same Department as Full-Time Titular Professor "C".

Dr. Islas belongs to the SNII CONAHCyT level 2 and has the desirable PRODEP profile. His areas of specialty are Organic Synthesis and Pharmaco-chemistry. In this context, his lines of research include the synthesis of polyheterocycles via Multicomponent Reactions (MCRs), drug synthesis, synthesis of ligands to assemble new MOFs and click reactions. This has allowed him to publish 51 articles in journals indexed in the Journal of Citation Reports (JCR), in addition to 15 international proceedings.

In 2018 he obtained the diploma for research in the Basic Sciences and Engineering area. Dr. Islas has directed 18 terminal projects with a specialty in organic chemistry, 10 social services and has graduated 1 master's thesis student. He currently directs 2 social services, 1 bachelor's terminal project, 2 master's theses and 2 doctoral thesis. Likewise, it is worth highlighting that he serves as Academic Coordinator of the DCBI Chemistry Teaching Laboratories at the UAM.



Information provided by the academic staff

Research interests

• Synthesis of Polyheterocycles via Multicomponent Reactions
• Drug synthesis
• Synthesis of ligands to assemble new MOFs
• Click reactions

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
Morales-Saavedra, O.G., Guarin, C.A., Hernández-Rojas, M.E. and 10 more (...) (2026).Synthesis and characterization of novel polymers containing poly((4-((4-nitrophenyl)ethynyl)phenyl)azanediyl)bis(ethane-2,1-diyl) as main chain and tolanic chromophores in the side chain with strong NLO-activity. Materials Chemistry and Physics,350
Frías-López, A.A., Vázquez-Fuentes, S., Garibay-Manríquez, C. and 6 more (...) (2025).Synthesis, In Vitro Activity, and Molecular Docking of 1,5-Disubstituted Tetrazol-1,2,3-triazole Hybrids against Fungal Plant Pathogen Botrytis cinerea and Colletotrichum gloeosporioides. Journal of Agricultural and Food Chemistry,73(43) 27233-27241| 2 |
OABlanco-Carapia, R.E., Hernández-López, R., Alcaraz-Estrada, S.L. and 9 more (...) (2025).Multi-Component Synthesis of New Fluorinated-Pyrrolo[3,4-b]pyridin-5-ones Containing the 4-Amino-7-chloroquinoline Moiety and In Vitro–In Silico Studies Against Human SARS-CoV-2. International Journal of Molecular Sciences,26(15) | 3 |
OAMarín-Rosas, P., Portillo-Veléz, N.S., Gabriel Flores, J. and 8 more (...) (2025).The Use of Porous Materials in Heterogeneous Catalysis. Journal of the Mexican Chemical Society,69(1) 259-267
OAPerez-Rangel, J.A., Servín-García, G., Gutiérrez-Carrillo, A. and 4 more (...) (2025).(5R,7R,11bR)-9-(di(1H-Indol-3-yl)methyl)-4,4,7,11b-tetramethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-5-yl Acetate. MolBank,2025(3)
OABlanco-Carapia, R.E., Islas-Jácome, A., González-Zamora, E. (2025).7,7′-(1,4-Phenylene)bis(2-benzyl-3-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one). MolBank,2025(4)
OASuárez-Moreno, G., Méndez, F., Gutierrez-Carrillo, A. and 4 more (...) (2025).NMR-Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza-Diels–Alder Cycloadditions. Magnetic Resonance in Chemistry,
OAFlores-Reyes, J.C., Amador-Sánchez, Y.A., Valderrama-Celestino, A. and 7 more (...) (2025).Dual-state emission of pyrazolyl-pyrrolo[3,4-b]pyridin-5-ones via excited-state intramolecular proton transfer (ESIPT): multicomponent synthesis and optical characterization. Organic Chemistry Frontiers,12(8) 2607-2616
OAMorales-Salazar, I., Bouillon, J.-P., González-Zamora, E. and 1 more (...) (2025).Non-Isocyanide-Based Three-Component Reactions: From Strecker to Nowadays. Journal of the Mexican Chemical Society,69(1) 185-258
OAMorales-Salazar, I., Islas-Jácome, P., Herrera-Zuñiga, L.D. and 5 more (...) (2025).Multicomponent Synthesis of Fluorine-Containing Bioactive Compounds and Drugs. European Journal of Organic Chemistry,28(38)
OAFlores-Reyes, J.C., Galano, A., Rojas-Montoya, S.M. and 6 more (...) (2024).Synthesis of BODIPY-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu/cascade reactions and studies of fluorescence response toward viscosity. Frontiers in Chemistry,12
Blanco-Carapia, R.E., Islas-Jácome, P., Gutiérrez-Carrillo, A. and 3 more (...) (2024).One-pot synthesis of phenyl- and biphenyl-linked bis-pyrrolo[3,4-b]pyridin-5-ones via a pseudo-repetitive Ugi-Zhu-5CR coupled to a double cascade process (aza-Diels-Alder/N-acylation/decarboxylation/dehydration). Tetrahedron Letters,151
Aguilar-Morales, C.M., Alejandre-Castaneda, V., Contreras-Celedon, C. and 5 more (...) (2024).A one-pot five component reaction for the synthesis of tetrazol-benzofuran hybrids and their inhibitory activity against Mucor lusitanicus. Organic and Biomolecular Chemistry,22(35) 7240-7244
Flores-Reyes, J.C., Valderrama-Celestino, A., Trejo-Velasco, M.F. and 6 more (...) (2024).Multicomponent synthesis of 7-(diethylamino)coumarin–pyrrolo[3,4-b]pyridin-5-one conjugates and modulation of their twisted intramolecular charge transfer (TICT) processes. Tetrahedron,168
Flores-Reyes, J.C., Rojas-Montoya, S.M., Blancarte-Carrazco, L. and 6 more (...) (2024).Multicomponent synthesis and photophysical properties of meso-thienyl BODIPY-pyrrolo[3,4-b]pyridin-5-ones. An experimental and theoretical study. Journal of Luminescence,273
Cortés-García, C.J., Mercado-Madrigal, A.I., Alejandre-Castañeda, V. and 9 more (...) (2024).Synthesis of Benzofuran-Based Hybrid Molecules: Molecular Docking and Antibacterial Activity Against Pseudomonas aeruginosa. Journal of Heterocyclic Chemistry,61(11) 1653-1667
OAGallo, L.M., Obeso, J.L., Portillo-Vélez, N.S. and 6 more (...) (2024).Effective BPA degradation in water: the integration of bimetallic UiO-66 Ce-Zr. RSC Advances,14(47) 35090-35096| 6 |
OAAguilar-Morales, C.M., Frías-López, A.A., Emilio-Velázquez, N.V. and 8 more (...) (2024).Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction. Beilstein Journal of Organic Chemistry,203077-3084| 3 |
OAMorales-Salazar, I., Garduño-Albino, C.E., Montes-Enríquez, F.P. and 8 more (...) (2024).In Vitro and In Silico Studies of Bis-furyl-pyrrolo[3,4-b]pyridin-5-ones on Dengue Virus. Journal of the Mexican Chemical Society,68(1) 170-183| 3 |
OABlanco-Carapia, R.E., Aguilar-Rangel, E.A., Rincón-Guevara, M.A. and 2 more (...) (2023).Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy. Molecules,28(10)
OAFlores-Reyes, J.C., Cotlame-Salinas, V.D.C., Ibarra, I.A. and 2 more (...) (2023).Pseudo-multicomponent reactions. RSC Advances,13(24) 16091-16125
OAIslas-Jácome, P., García-Falcón, C., Castañón-Alonso, S.L. and 4 more (...) (2023).2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one. MolBank,2023(3)
OAFlores, J.G., Obeso, J.L., Martínez-Jiménez, V. and 11 more (...) (2023).Evaluation of the catalytic activity of Zn-MOF-74 for the alcoholysis of cyclohexene oxide. RSC Advances,13(39) 27174-27179
Servín-García, G., Chacón-García, L., Islas-Jácome, A. and 4 more (...) (2023).Late-stage functionalization of Vouacapane derivatives from Caesalpinia platyloba by a Groebke−Blackburn−Bienaymé reaction. Journal of Heterocyclic Chemistry,60(11) 1903-1910
Aguilar-Morales, C.M., Servín-García, G., del Río, R.E. and 4 more (...) (2023).Synthesis of novel hybrid 1,5-disusbtituted 1H-tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5-a]pyrazin-6-ones via high-order MCR-SN 2/intramolecular [3 + 2] cycloaddition sequence. Synthetic Communications,53(2) 127-134
López-Cervantes, V.B., Obeso, J.L., Yañez-Aulestia, A. and 5 more (...) (2023).MFM-300(Sc): a chemically stable Sc(iii)-based MOF material for multiple applications. Chemical Communications,59(69) 10343-10359
OAMorales-Salazar, I., Garduño-Albino, C.E., Montes-Enríquez, F.P. and 5 more (...) (2023).Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma. Pharmaceuticals,16(11) | 3 |
OAMorales-Salazar, I., Rincón-Guevara, M.A., González-Zamora, E. and 1 more (...) (2022).2-Benzyl-3-morpholino-7-(thiophen-2-yl)-6-(thiophen-2-ylmethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one. MolBank,2022(4)
OAMorales-Salazar, I., Montes-Enríquez, F.P., Garduño-Albino, C.E. and 9 more (...) (2022).Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins. RSC Medicinal Chemistry,14(1) 154-165| 3 |
Niño-Pantoja, I., Gallardo-Alfonzo, A., Solis-Santos, M. and 5 more (...) (2022).Synthesis of 1,5-Disubstituted Tetrazole−Indolizine Bis-Heterocycles and Their Copper (II) Recognizing Properties. European Journal of Organic Chemistry,
OABlanco-Carapia, R.E., Aguilar-Rangel, E.A., Islas-Jácome, A. and 1 more (...) (2022).Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine). MolBank,2022(3)
Obeso, J.L., López-Olvera, A., Flores, C.V. and 11 more (...) (2022).Methylene blue adsorption in DUT-5: Relatively strong host-guest interactions elucidated by FTIR, solid-state NMR, and XPS. Journal of Molecular Liquids,368
Flores-Reyes, J.C., Islas-Jácome, A., González-Zamora, E. (2021).The Ugi three-component reaction and its variants. Organic Chemistry Frontiers,8(19) 5460-5515
OACotlame-Salinas, V.D.C., López-Olvera, A., Islas-Jácome, A. and 2 more (...) (2021).CO2capture enhancement in MOFs: Via the confinement of molecules. Reaction Chemistry and Engineering,6(3) 441-453| 13 |
OAAlmaraz-Girón, M.A., Calderón-Jaimes, E., Carrillo, A.S. and 5 more (...) (2021).Search for non-protein protease inhibitors constituted with an indole and acetylene core. Molecules,26(13) | 3 |
OAAguilar-Morales, C.M., Araujo-Huitrado, J.G., López-Hernández, Y. and 7 more (...) (2021).A one-pot six-component reaction for the synthesis of 1,5-disubstituted tetrazol-1,2,3-triazole hybrids and their cytotoxic activity against the mcf-7 cell line. Molecules,26(20) | 3 |
OAAlvarado-Alvarado, D., González-Estefan, J.H., Flores, J.G. and 9 more (...) (2020).Water Adsorption Properties of Fe(pz)[Pt(CN)4] and the Capture of CO2 and CO. Organometallics,39(7) 949-955| 13 |
OACastañón-Alonso, S.L., Morales-Saavedra, O.G., Almaraz-Girón, M.A. and 7 more (...) (2020).Quadratic non-linear optical properties of the poly(2,5-bis(but-2-ynyloxy) benzoate containing the 2-(ethyl(4-(4-nitrophenyl)buta-1,3-diynyl) phenyl)amino)ethanol) chromophore. Polymers,12(1)
OASánchez-González, E., Flores, J.G., Flores-Reyes, J.C. and 7 more (...) (2020).Bottleneck effect explained by Le Bail Refinements: Structure transformation of Mg-CUK-1 by confining H2O molecules. Materials,13(8) | 13 |

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
25O
Química Orgánica ILicenciatura
2
25O
Síntesis de FármacosLicenciatura
3
25O
Química AtmosféricaLicenciatura
4
25O
QuimiometríaLicenciatura
5
25O
Introducción a la Investigación IPosgrado
6
25O
Introducción a la Investigación IPosgrado
7
25O
Introducción a la Investigación IIIPosgrado
8
25O
Química y Física del AguaLicenciatura
9
25P
Temas Selectos en FarmoquímicaLicenciatura
10
25P
Introducción a la Investigación IIIPosgrado
11
25P
Introducción a la Investigación IIPosgrado
12
25P
Proyecto Terminal II Química OrgánicaLicenciatura
13
25P
Proyecto Terminal II Química OrgánicaLicenciatura
14
25P
Química Orgánica IIILicenciatura
15
25I
Introducción a la Investigación IPosgrado
16
25I
Introducción a la Investigación IIPosgrado
17
25I
Resonancia MagnéticaPosgrado
18
25I
Proyecto Terminal II Química OrgánicaLicenciatura
19
25I
Proyecto Terminal I Química OrgánicaLicenciatura
20
25I
Química Orgánica IIILicenciatura
21
25I
Síntesis de FármacosLicenciatura
22
25I
Proyecto Terminal I Química OrgánicaLicenciatura
23
24O
Temas Selectos en FarmoquímicaLicenciatura
24
24O
Proyecto Terminal I Química OrgánicaLicenciatura
25
24O
Proyecto Terminal II Química OrgánicaLicenciatura
26
24O
Resonancia MagnéticaPosgrado
27
24O
Introducción a la Investigación IPosgrado
28
24P
Proyecto Terminal I Química OrgánicaLicenciatura
29
24P
Trabajo de Investigación VIPosgrado
30
24P
Introducción a la Investigación IIIPosgrado
31
24P
Proyecto Terminal II Química OrgánicaLicenciatura
32
24P
Síntesis de FármacosLicenciatura
33
24P
Química Orgánica IILicenciatura
34
24I
Proyecto Terminal I Química OrgánicaLicenciatura
35
24I
Proyecto Terminal II Química OrgánicaLicenciatura
36
24I
Química Orgánica IIILicenciatura
37
24I
Síntesis de FármacosLicenciatura
38
24I
Temas Selectos en FarmoquímicaLicenciatura
39
24I
Introducción a la Investigación IIPosgrado
40
23O
Trabajo de Investigación VPosgrado
41
23O
Resonancia MagnéticaPosgrado
42
23O
Proyecto Terminal I Química OrgánicaLicenciatura
43
23O
Química Orgánica IILicenciatura
44
23P
Química Orgánica ILicenciatura
45
23P
Síntesis de FármacosLicenciatura
46
23P
Temas Selectos en FarmoquímicaLicenciatura
47
23P
Proyecto Terminal II Química OrgánicaLicenciatura
48
23P
Proyecto Terminal II Química OrgánicaLicenciatura
49
23P
Proyecto Terminal II Química OrgánicaLicenciatura
50
23P
Trabajo de Investigación IVPosgrado
51
23I
Síntesis de FármacosLicenciatura
52
23I
Trabajo de Investigación IIIPosgrado
53
23I
Proyecto Terminal II Química OrgánicaLicenciatura
54
23I
Proyecto Terminal II Química OrgánicaLicenciatura
55
23I
Proyecto Terminal I Química OrgánicaLicenciatura
56
23I
Proyecto Terminal I Química OrgánicaLicenciatura
57
23I
Proyecto Terminal I Química OrgánicaLicenciatura
58
23I
Química Orgánica IIILicenciatura
59
22O
Proyecto Terminal II Química OrgánicaLicenciatura
60
22O
Trabajo de Investigación IIPosgrado
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Universidad Autónoma Metropolitana, 2025.