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Perfil investigador
Esp
Dr. Silvestre de Jesús Alavez Espidio

Professor
Departament of Health Sciences

Division of Biological and Health Sciences


Level 2
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Lerma Campus

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Sustainable Development Goals

• 3 Good Health and Well-being


Research interests

• Molecular mechanisms of aging
• Pharmacological interventions targeting aging
• Natural products as geroprotectors
• Protein aggregation and aging
• Epidemiology of aging and disease in Mexican population

Profile

Doctor Silvestre Alavez is a Professor and Dean of the Biological and Health Sciences Division at the Universidad Autónoma Metropolitana (UAM) Lerma Campus. Professor Alavez obtained a degree in Chemistry and a Ph.D. in Biochemistry from the Universidad Nacional Autónoma de México (UNAM), where his area of expertise was Neurochemistry, and a very solid training and experience in aging research at the Buck Institute for Research on Aging in Novato, California. His work has been published in the most prestigious journals such as Nature, Cell Metabolism, and Aging Cell, and he is a member of the National System of Researchers at Level II.

Using the earthworm C. elegans as an experimental model, the objectives of his research are (i) to understand the role of protein homeostasis in aging (ii) the systematic identification of compounds with the potential to become pharmacological interventions to extend life expectancy and promote healthy aging in humans and (iii) to understand the epidemiological basis of aging and disease in the Mexican population.



Information provided by the academic staff

Research interests

• Molecular mechanisms of aging
• Pharmacological interventions targeting aging
• Natural products as geroprotectors
• Protein aggregation and aging
• Epidemiology of aging and disease in Mexican population

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAArroyo-Quiroz, C., Alavez, S. (2026).Impact of the SARS-CoV-2 pandemic on healthy aging and functionality in older Mexican adults: insights from the MHAS cohort. Aging Clinical and Experimental Research,38(1) 3
OAArroyo-Quiroz, C., Monroy, A., Alavez, S. (2026).Impact of the COVID-19 Pandemic on Coronary Heart Disease Admissions and Mortality in Mexico: An Ecological Study. Health Science Reports,9(4) 3
Gómez-Linton, D.R., Monroy, A., Alavez, S. and 1 more (...) (2026).An Update on the Therapeutic Potential of Bixin and Norbixin Apocarotenoids. Planta Medica,92(10) 945-962
OAValle-Jiménez, X., Osorio-Paz, I., Alavez, S. (2025).Phenolic Acids Commonly Found in Natural Products Modulate Protein Aggregation in Caenorhabditis elegans Neurodegeneration Models. ACS Omega,10(26) 27861-27868
OAKuschinski, N., Christen, J.A., Monroy, A. and 1 more (...) (2025).Modeling Oral Glucose Tolerance Test (OGTT) Data and Its Bayesian Inverse Problem. Springer Proceedings in Mathematics and Statistics,47961-713
OAArroyo-Quiroz, C., Brunauer, R., Alavez, S. (2023).Education and employment have a sex-dependent effect on healthy aging in Mexico. Geriatrics and Gerontology International,23(12) 980-981
OAOsorio-Paz, I., Valle-Jiménez, X., Brunauer, R. and 1 more (...) (2023).Vanillic Acid Improves Stress Resistance and Substantially Extends Life Span in Caenorhabditis elegans. Journals of Gerontology - Series A Biological Sciences and Medical Sciences,78(7) 1100-11073
OAFranco-Vásquez, D.C., Carreón-Hidalgo, J.P., Gómez-Linton, D.R. and 5 more (...) (2023).CONTENIDO Conventional and non-conventional extraction of functional compounds from jiotilla (Escontria chiotilla) fruits and evaluation of their antioxidant activity Volumen 8, número 3, 2009 / Volume 8, number 3, 2009. Revista Mexicana de Ingeniera Quimica,22(1)
OAGómez-Linton, D.R., Navarro-Ocaña, A., Alavez, S. and 5 more (...) (2022).Extraction of Lipophilic Antioxidants from Native Tomato Using Green Technologies. Food Technology and Biotechnology,60(1) 121-1317
Arroyo-Quiroz, C., Brunauer, R., Alavez, S. (2022).Sugar-Sweetened Beverages and Cancer Risk: A Narrative Review. Nutrition and Cancer,74(9) 3077-30953
Monroy, A., Mez-Laguna, L.G., Aranda-Flores, C.E. and 1 more (...) (2022).Insulin Resistance and Cancer: Clinical and Molecular Evidence. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects,32265-22823
Gómez-Linton, D.R., Navarro-Ocaña, A., Lobato-Ortiz, R. and 3 more (...) (2022).Effect of Tomato Extract on the Stress Resistance and Lifespan of Caenorhabditis elegans. Revista Brasileira de Farmacognosia,32(4) 645-650
OAGómez-Linton, D.R., Navarro-Ocaña, A., Román-Guerrero, A. and 4 more (...) (2021).Environmentally friendly achiote seed extracts with higher δ-tocotrienol content have higher in vitro and in vivo antioxidant activity than the conventional extract. Journal of Food Science and Technology,58(7) 2579-2588
Vargas, P., Moreles, M.A., Peña, J. and 2 more (...) (2021).Estimation and SVM classification of glucose-insulin model parameters from OGTT data: a comparison with the ADA criteria: Estimation and SM classification of glucose-insulin model parameters. International Journal of Diabetes in Developing Countries,41(1) 54-623
Gómez-Linton, D.R., Alavez, S., Navarro-Ocaña, A. and 3 more (...) (2020).Achiote (Bixa orellana) Lipophilic Extract, Bixin, and δ -tocotrienol Effects on Lifespan and Stress Resistance in Caenorhabditis elegans. Planta Medica,87(5) 368-374
OAArroyo-Quiroz, C., Brunauer, R., Alavez, S. (2020).Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults. Maturitas,13121-273
OAGómez-Linton, D.R., Navarro-Ocaña, A., Alavez, S. and 3 more (...) (2020).Effect of sonication on the content of bixin, norbixin, total phenols and antioxidant activity of extracts of five achiote accessions. Revista Mexicana de Ingeniera Quimica,19(3) 1083-1094
Osorio-Paz, I., Brunauer, R., Alavez, S. (2020).Beer and its non-alcoholic compounds in health and disease. Critical Reviews in Food Science and Nutrition,60(20) 3492-35053

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26P
Temas Selectos Interdivisionales en Ciencia y Tecnología de Alimentos ILicenciatura
2
26P
Tópicos Selectos Interdisciplinarios IIILicenciatura
3
26P
Temas Selectos Interdivisionales XIVLicenciatura
4
26P
Proyecto InterdisciplinarioLicenciatura
5
26I
Proyecto InterdisciplinarioLicenciatura
6
25O
Eje Integrador V: Practicas ProfesionalesLicenciatura
7
25O
Proyecto InterdisciplinarioLicenciatura
8
25P
Eje Integrador V: Practicas ProfesionalesLicenciatura
9
25P
Tópicos Selectos Interdisciplinarios IVLicenciatura
10
25I
Eje Integrador V: Practicas ProfesionalesLicenciatura
11
24O
Eje Integrador IV: Anteproyecto TerminalLicenciatura
12
24P
Temas Selectos en Ingeniería Biológica ILicenciatura
13
24P
Temas Selectos en Ingeniería Biológica IILicenciatura
14
24P
Temas Selectos en Ingeniería Biológica IIILicenciatura
15
24P
Temas Selectos Interdivisionales IILicenciatura
16
24P
Tópicos Selectos Interdisciplinarios IIILicenciatura
17
24I
Trabajo de Redacción de Tesis IIIPosgrado
18
24I
Tópicos Selectos Interdisciplinarios IIILicenciatura
19
23O
Temas Selectos Interdivisionales ILicenciatura
20
23O
Proyecto Terminal de Psicología Biomédica IILicenciatura
21
23O
Taller Optativo Interdivisional IILicenciatura
22
23O
Taller Optativo Interdivisional IIILicenciatura
23
23O
Taller Optativo Interdivisional XLicenciatura
24
23O
Tópicos Selectos Interdisciplinarios IVLicenciatura
25
23O
Trabajo de Redacción de Tesis IIPosgrado
26
23P
Proyecto Terminal de Psicología Biomédica IILicenciatura
27
23P
Introducción a Las GeocienciasLicenciatura
28
23P
Proyecto Terminal de Psicología Biomédica ILicenciatura
29
23P
Tópicos Selectos Interdisciplinarios VLicenciatura
30
23P
Trabajo de Redacción de Tesis IPosgrado
31
23I
Tópicos Selectos Interdisciplinarios IIILicenciatura
32
23I
Proyecto Terminal de Psicología Biomédica ILicenciatura
33
23I
Seminario VIIPosgrado
34
23I
Trabajo de Investigación IXPosgrado
35
22O
Tópicos Selectos Interdisciplinarios IIILicenciatura
36
22O
Trabajo de Investigación VIIIPosgrado
37
22P
Trabajo de Investigación VIIPosgrado
38
22P
Biología CelularLicenciatura
39
22P
Proyecto Terminal en Ciencia y Tecnología de Alimentos IILicenciatura
40
22P
Proyecto Terminal en Ciencia y Tecnología de Alimentos ILicenciatura
41
22P
Proyecto Terminal de Psicología Biomédica IILicenciatura
42
22P
Proyecto Terminal de Psicología Biomédica ILicenciatura
43
22P
Proyecto Terminal de Biología Ambiental IILicenciatura
44
22P
Proyecto Terminal de Biología Ambiental ILicenciatura
45
22P
Optativa Divisional de Ciencias Biológicas y de la Salud ILicenciatura
46
22P
Eje Integrador IV: Anteproyecto TerminalLicenciatura
47
22I
Eje Integrador II: Psicología EvolutivaLicenciatura
48
22I
Optativa Divisional de Ciencias Biológicas y de la Salud ILicenciatura
49
22I
Proyecto Terminal de Psicología Biomédica ILicenciatura
50
22I
Seminario VIPosgrado
51
22I
Trabajo de Investigación VIPosgrado
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Universidad Autónoma Metropolitana, 2026.