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Perfil investigador
Esp
Dr. Juan Carlos Sigala Alanís

Professor
Departament of Process and Technology

Division of Natural Sciences and Engineering


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Cuajimalpa Campus

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Sustainable Development Goals

• 4 Quality Education

• 7 Affordable and Clean Energy


Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Profile

Professor Juan Carlos Sígala Alanís is a graduate of the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM); he completed his Ph.D. in Sciences at the Institute of Biotechnology of the same University under the direction of Dr. Francisco Bolívar Zapata. He has two postdoctoral stays, one at the Institute of Biotechnology of the UNAM (2009) and another at the Institute of Bioengineering of the Technical University of Braunschweig, Germany (2010) in the group of Dr. Christoph Wittmann.

He has been involved in biotechnological projects, including the design and genetic modification of microorganisms, establishing the best conditions for growth and production, and the study of metabolism through various systems biology techniques.

In July 2011, he joined the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus. His research lines consider the following main topics: microbial physiology, metabolic engineering in bacteria, and characterization of microorganisms based on transcription analysis.

He has 18 scientific articles in international journals until 2019, one national divulgation article, and has been tutor of three bachelor's thesis, four master's thesis, and one specialization thesis. He is a National Researcher, Level I of the National System of Researchers in the period 2019-2021. He has taught several courses at the undergraduate and graduate level at the Cuajimalpa Campus of the UAM, at the Faculty of Chemistry of the UNAM, at the ITESM Campus Cd. de México.



Information provided by the academic staff

Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
Estrada-Graf, A.A., Sigala, J.-C., Sánchez-Pérez, M. and 1 more (...) (2024).Induction of lipid production through controlled acidification: A transcriptional insight into the metabolism of Scenedesmus obtusiusculus AT-UAM. Process Biochemistry,147175-185| 7 |
OALara, A.R., Kunert, F., Vandenbroucke, V. and 6 more (...) (2024).Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit. Biotechnology and Bioengineering,121(6) 1789-1802
OAArteaga, J.E., Rivera-Becerril, E., Le Borgne, S. and 1 more (...) (2024).Influence of furfural on the physiology of Acinetobacter baylyi ADP1. FEMS Microbiology Letters,371
Lara, A.R., Utrilla, J., Martínez, L.M. and 8 more (...) (2024).Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes. Biotechnology and Bioengineering,121(4) 1216-1230
OAde la Cruz, M., Kunert, F., Taymaz-Nikerel, H. and 4 more (...) (2024).Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered E. coli. Microorganisms,12(1)
OAIslas, F., Sabido, A., Sigala, J.-C. and 1 more (...) (2023).Design of microaerobically inducible miniR1 plasmids. mLife,2(1) 101-104
OACastillo-Plata, A.K., Sigala, J.C., Lappe-Oliveras, P. and 1 more (...) (2022).KCL/KOH supplementation improves acetic acid tolerance and ethanol production in a thermotolerant strain of kluyveromyces marxianus isolated from henequen (Agave fourcroydes). Revista Mexicana de Ingeniera Quimica,21(1) | 7 |
OAVelazquez, D., Sigala, J.-C., Martínez, L.M. and 3 more (...) (2022).Glucose transport engineering allows mimicking fed-batch performance in batch mode and selection of superior producer strains. Microbial Cell Factories,21(1)
Velazquez, D., Jaén, K.E., Sigala, J.-C. and 1 more (...) (2021).Minimized backbone and novel microaerobic promoters boost plasmid DNA production. Process Biochemistry,106130-136| 9 |
Arteaga, J.E., Cerros, K., Rivera-Becerril, E. and 3 more (...) (2021).Furfural biotransformation in Acinetobacter baylyi ADP1 and Acinetobacter schindleri ACE. Biotechnology Letters,43(5) 1043-1050
Juárez, M., González-De La Rosa, C.H., Sigala, J.C. and 1 more (...) (2021).Effect of vitreoscilla hemoglobin on recombinant protein expression and energy and redox state of cho cells. Revista Mexicana de Ingeniera Quimica,20(1) 281-288
Jaén, K.E., Velazquez, D., Sigala, J.-C. and 1 more (...) (2021).Enhancing microaerobic plasmid DNA production by chromosomal expression of Vitreoscilla hemoglobin in E. coli. Biochemical Engineering Journal,166
OALara, A.R., Galindo, J., Jaén, K.E. and 2 more (...) (2020).Physiological response of escherichia coli W3110 and BL21 to the aerobic expression of vitreoscilla hemoglobin. Journal of Microbiology and Biotechnology,30(10) 1592-1596
OAde la Cruz, M., Ramírez, E.A., Sigala, J.-C. and 2 more (...) (2020).Plasmid DNA production in proteome-reduced Escherichia coli. Microorganisms,8(9) 1-8

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
25O
Proyecto Terminal ILicenciatura
2
25O
Proyecto Terminal ILicenciatura
3
25O
Proyecto Terminal ILicenciatura
4
25O
Proyecto Terminal ILicenciatura
5
25O
Proyecto Terminal IILicenciatura
6
25O
Biología MolecularPosgrado
7
25O
Proyecto de Investigación Doctoral XIIPosgrado
8
25O
Ingeniería Genética y Técnicas MolecularesLicenciatura
9
25P
Introducción a la Ingeniería BiológicaLicenciatura
10
25P
Proyecto de Investigación Doctoral XIPosgrado
11
25P
Proyecto Terminal ILicenciatura
12
25P
MicrobiologíaLicenciatura
13
25I
Biología MolecularLicenciatura
14
25I
BioinformáticaLicenciatura
15
25I
Bioinformática IPosgrado
16
25I
Seminario Doctoral IVPosgrado
17
25I
Proyecto de Investigación Doctoral XPosgrado
18
24O
Proyecto de Investigación Doctoral IXPosgrado
19
24P
Proyecto Terminal IILicenciatura
20
24P
Proyecto de Investigación Doctoral VIIIPosgrado
21
24P
Seminario Doctoral IVPosgrado
22
24P
Seminario Doctoral IIIPosgrado
23
24P
Proyecto Terminal IILicenciatura
24
24I
Proyecto Terminal IILicenciatura
25
24I
Proyecto Terminal IILicenciatura
26
24I
Proyecto Terminal IILicenciatura
27
24I
Proyecto de Investigación Doctoral VIIPosgrado
28
24I
Proyecto de Investigación Doctoral XPosgrado
29
23O
Proyecto Terminal ILicenciatura
30
23O
Proyecto Terminal ILicenciatura
31
23O
Seminario Doctoral IIIPosgrado
32
23O
Proyecto de Investigación Doctoral IVPosgrado
33
23O
Proyecto de Investigación Doctoral VIPosgrado
34
23O
Proyecto de Investigación Doctoral IXPosgrado
35
23O
Proyecto de Investigación Doctoral XIIPosgrado
36
23P
Proyecto de Investigación Doctoral IIIPosgrado
37
23P
Proyecto de Investigación Doctoral VPosgrado
38
23P
Proyecto de Investigación Doctoral VIIIPosgrado
39
23P
Proyecto de Investigación Doctoral XIPosgrado
40
23P
Proyecto Terminal IILicenciatura
41
23P
Proyecto Terminal IILicenciatura
42
23P
Proyecto Terminal IILicenciatura
43
23P
Proyecto Terminal ILicenciatura
44
23I
Proyecto de Investigación Doctoral IIPosgrado
45
23I
Proyecto de Investigación Doctoral IVPosgrado
46
23I
Proyecto de Investigación IIIPosgrado
47
23I
Proyecto de Investigación Doctoral XPosgrado
48
23I
Proyecto de Investigación Doctoral VIIPosgrado
49
23I
Proyecto Terminal IILicenciatura
50
23I
Biología MolecularLicenciatura
51
22O
Proyecto de Investigación Doctoral IPosgrado
52
22O
Proyecto de Investigación Doctoral IXPosgrado
53
22O
Proyecto de Investigación Doctoral VIPosgrado
54
22O
Proyecto de Investigación Doctoral IIIPosgrado
55
22O
Seminario Doctoral IIPosgrado
56
22O
Proyecto de Investigación IIIPosgrado
57
22O
Trabajo de Especialidad IIIPosgrado
58
22O
Temas Selectos en Ingeniería Biológica IILicenciatura
59
22O
Temas Selectos en Ciencias ILicenciatura
60
22O
Proyecto Terminal IILicenciatura
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