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Perfil investigador
Esp
Dr. Juan Carlos Sigala Alanís

Professor
Departament of Process and Technology

Division of Natural Sciences and Engineering


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Cuajimalpa Campus

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Sustainable Development Goals

• 4 Quality Education

• 7 Affordable and Clean Energy


Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Profile

Professor Juan Carlos Sígala Alanís is a graduate of the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM); he completed his Ph.D. in Sciences at the Institute of Biotechnology of the same University under the direction of Dr. Francisco Bolívar Zapata. He has two postdoctoral stays, one at the Institute of Biotechnology of the UNAM (2009) and another at the Institute of Bioengineering of the Technical University of Braunschweig, Germany (2010) in the group of Dr. Christoph Wittmann.

He has been involved in biotechnological projects, including the design and genetic modification of microorganisms, establishing the best conditions for growth and production, and the study of metabolism through various systems biology techniques.

In July 2011, he joined the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus. His research lines consider the following main topics: microbial physiology, metabolic engineering in bacteria, and characterization of microorganisms based on transcription analysis.

He has 18 scientific articles in international journals until 2019, one national divulgation article, and has been tutor of three bachelor's thesis, four master's thesis, and one specialization thesis. He is a National Researcher, Level I of the National System of Researchers in the period 2019-2021. He has taught several courses at the undergraduate and graduate level at the Cuajimalpa Campus of the UAM, at the Faculty of Chemistry of the UNAM, at the ITESM Campus Cd. de México.



Information provided by the academic staff

Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAFragoso-Jiménez, J.C., Sigala, J.C., Delvigne, F. and 3 more (...) (2026).Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli. Biotechnology Journal,21(6)
OAEstrada-Graf, A.A., Sigala, J.-C., Sánchez-Pérez, M. and 1 more (...) (2026).Transcriptomic evidence supports a malate–oxaloacetate–pyruvate cycle linking photosynthetic overflow to lipid biosynthesis in Scenedesmus obtusiusculus AT-UAM. Process Biochemistry,169113-1257
Lara, A.R., Utrilla, J., Martínez, L.M. and 8 more (...) (2024).Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes. Biotechnology and Bioengineering,121(4) 1216-1230
Estrada-Graf, A.A., Sigala, J.-C., Sánchez-Pérez, M. and 1 more (...) (2024).Induction of lipid production through controlled acidification: A transcriptional insight into the metabolism of Scenedesmus obtusiusculus AT-UAM. Process Biochemistry,147175-1857
OALara, A.R., Kunert, F., Vandenbroucke, V. and 6 more (...) (2024).Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit. Biotechnology and Bioengineering,121(6) 1789-1802
OAde la Cruz, M., Kunert, F., Taymaz-Nikerel, H. and 4 more (...) (2024).Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered E. coli. Microorganisms,12(1)
OAArteaga, J.E., Rivera-Becerril, E., Le Borgne, S. and 1 more (...) (2024).Influence of furfural on the physiology of Acinetobacter baylyi ADP1. FEMS Microbiology Letters,371
OAIslas, F., Sabido, A., Sigala, J.-C. and 1 more (...) (2023).Design of microaerobically inducible miniR1 plasmids. mLife,2(1) 101-104
OAVelazquez, D., Sigala, J.-C., Martínez, L.M. and 3 more (...) (2022).Glucose transport engineering allows mimicking fed-batch performance in batch mode and selection of superior producer strains. Microbial Cell Factories,21(1)
OACastillo-Plata, A.K., Sigala, J.C., Lappe-Oliveras, P. and 1 more (...) (2022).KCL/KOH supplementation improves acetic acid tolerance and ethanol production in a thermotolerant strain of kluyveromyces marxianus isolated from henequen (Agave fourcroydes). Revista Mexicana de Ingeniera Quimica,21(1) 7
Arteaga, J.E., Cerros, K., Rivera-Becerril, E. and 3 more (...) (2021).Furfural biotransformation in Acinetobacter baylyi ADP1 and Acinetobacter schindleri ACE. Biotechnology Letters,43(5) 1043-1050
Juárez, M., González-De La Rosa, C.H., Sigala, J.C. and 1 more (...) (2021).Effect of vitreoscilla hemoglobin on recombinant protein expression and energy and redox state of cho cells. Revista Mexicana de Ingeniera Quimica,20(1) 281-288
Jaén, K.E., Velazquez, D., Sigala, J.-C. and 1 more (...) (2021).Enhancing microaerobic plasmid DNA production by chromosomal expression of Vitreoscilla hemoglobin in E. coli. Biochemical Engineering Journal,166
Velazquez, D., Jaén, K.E., Sigala, J.-C. and 1 more (...) (2021).Minimized backbone and novel microaerobic promoters boost plasmid DNA production. Process Biochemistry,106130-1369
OAde la Cruz, M., Ramírez, E.A., Sigala, J.-C. and 2 more (...) (2020).Plasmid DNA production in proteome-reduced Escherichia coli. Microorganisms,8(9) 1-8
OALara, A.R., Galindo, J., Jaén, K.E. and 2 more (...) (2020).Physiological response of escherichia coli W3110 and BL21 to the aerobic expression of vitreoscilla hemoglobin. Journal of Microbiology and Biotechnology,30(10) 1592-1596

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26P
Optativa de Movilidad de Intercambio IILicenciatura
2
26P
Optativa de Movilidad de Intercambio IIILicenciatura
3
26P
Optativa de Movilidad de Intercambio IIILicenciatura
4
26P
Optativa de Movilidad de Intercambio IVLicenciatura
5
26P
Optativa de Movilidad de Intercambio IVLicenciatura
6
26P
Optativa de Movilidad de Intercambio IILicenciatura
7
26P
Optativa de Movilidad de Intercambio IILicenciatura
8
26P
Optativa de Movilidad de Intercambio IILicenciatura
9
26P
Optativa de Movilidad de Intercambio IILicenciatura
10
26P
Optativa de Movilidad de Intercambio IILicenciatura
11
26P
Optativa de Movilidad de Intercambio IIILicenciatura
12
26P
Optativa de Movilidad de Intercambio IIILicenciatura
13
26P
Optativa de Movilidad de Intercambio IIILicenciatura
14
26P
Optativa de Movilidad de Intercambio IILicenciatura
15
26P
Optativa de Movilidad de Intercambio IILicenciatura
16
26P
Optativa de Movilidad de Intercambio IILicenciatura
17
26P
Optativa de Movilidad de Intercambio IIILicenciatura
18
26P
Optativa de Movilidad de Intercambio ILicenciatura
19
26P
Optativa de Movilidad de Intercambio ILicenciatura
20
26P
Optativa de Movilidad de Intercambio IILicenciatura
21
26P
Optativa de Movilidad de Intercambio ILicenciatura
22
26P
Optativa de Movilidad de Intercambio ILicenciatura
23
26P
Optativa de Movilidad de Intercambio ILicenciatura
24
26P
Optativa de Movilidad de Intercambio ILicenciatura
25
26P
Optativa de Movilidad de Intercambio ILicenciatura
26
26P
Optativa de Movilidad de Intercambio ILicenciatura
27
26P
Optativa de Movilidad de Intercambio ILicenciatura
28
26P
Optativa de Movilidad de Intercambio ILicenciatura
29
26P
Proyecto Terminal ILicenciatura
30
26P
Ingeniería Genética y Técnicas MolecularesLicenciatura
31
26P
Seminario sobre SustentabilidadLicenciatura
32
26P
Optativa de Movilidad de Intercambio IIILicenciatura
33
26P
Optativa de Movilidad de Intercambio IIILicenciatura
34
26P
Optativa de Movilidad de Intercambio IVLicenciatura
35
26P
Optativa de Movilidad de Intercambio IVLicenciatura
36
26P
Optativa de Movilidad de Intercambio IIILicenciatura
37
26P
Optativa de Movilidad de Intercambio IVLicenciatura
38
26P
Proyecto de Investigación IPosgrado
39
26P
Optativa de Movilidad de Intercambio IVLicenciatura
40
26P
Optativa de Movilidad de Intercambio IVLicenciatura
41
26P
Optativa de Movilidad de Intercambio IIILicenciatura
42
26P
Optativa de Movilidad de Intercambio IVLicenciatura
43
26P
Optativa de Movilidad de Intercambio IVLicenciatura
44
26P
Optativa de Movilidad de Intercambio IIILicenciatura
45
26P
Optativa de Movilidad de Intercambio IVLicenciatura
46
26P
Optativa de Movilidad de Intercambio IVLicenciatura
47
26I
Optativa de Movilidad de Intercambio ILicenciatura
48
26I
Optativa de Movilidad de Intercambio ILicenciatura
49
26I
Optativa de Movilidad de Intercambio ILicenciatura
50
26I
Optativa de Movilidad de Intercambio ILicenciatura
51
26I
Optativa de Movilidad de Intercambio IIILicenciatura
52
26I
Optativa de Movilidad de Intercambio IIILicenciatura
53
26I
Optativa de Movilidad de Intercambio IIILicenciatura
54
26I
Optativa de Movilidad de Intercambio IVLicenciatura
55
26I
Optativa de Movilidad de Intercambio IVLicenciatura
56
26I
Optativa de Movilidad de Intercambio IVLicenciatura
57
26I
Optativa de Movilidad de Intercambio IVLicenciatura
58
26I
Optativa de Movilidad de Intercambio IVLicenciatura
59
26I
Optativa de Movilidad de Intercambio IVLicenciatura
60
26I
Optativa de Movilidad de Intercambio IVLicenciatura
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Universidad Autónoma Metropolitana, 2026.