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Perfil investigador
Esp
Dr. Juan Carlos Sigala Alanís

Professor
Departament of Process and Technology

Division of Natural Sciences and Engineering


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Cuajimalpa Campus

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Sustainable Development Goals

• 4 Quality Education

• 7 Affordable and Clean Energy


Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Profile

Professor Juan Carlos Sígala Alanís is a graduate of the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM); he completed his Ph.D. in Sciences at the Institute of Biotechnology of the same University under the direction of Dr. Francisco Bolívar Zapata. He has two postdoctoral stays, one at the Institute of Biotechnology of the UNAM (2009) and another at the Institute of Bioengineering of the Technical University of Braunschweig, Germany (2010) in the group of Dr. Christoph Wittmann.

He has been involved in biotechnological projects, including the design and genetic modification of microorganisms, establishing the best conditions for growth and production, and the study of metabolism through various systems biology techniques.

In July 2011, he joined the Universidad Autónoma Metropolitana (UAM) Cuajimalpa Campus. His research lines consider the following main topics: microbial physiology, metabolic engineering in bacteria, and characterization of microorganisms based on transcription analysis.

He has 18 scientific articles in international journals until 2019, one national divulgation article, and has been tutor of three bachelor's thesis, four master's thesis, and one specialization thesis. He is a National Researcher, Level I of the National System of Researchers in the period 2019-2021. He has taught several courses at the undergraduate and graduate level at the Cuajimalpa Campus of the UAM, at the Faculty of Chemistry of the UNAM, at the ITESM Campus Cd. de México.



Information provided by the academic staff

Research interests

• Microbiology
• Metabolic Engineering
• Systems Biology
• Transcriptional Analysis
• Cellular Engineering

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
Lara, A.R., Utrilla, J., Martínez, L.M. and 8 more (...) (2024).Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes. Biotechnology and Bioengineering,121(4) 1216-1230
OALara, A.R., Kunert, F., Vandenbroucke, V. and 6 more (...) (2024).Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit. Biotechnology and Bioengineering,121(6) 1789-1802
OAde la Cruz, M., Kunert, F., Taymaz-Nikerel, H. and 4 more (...) (2024).Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered E. coli. Microorganisms,12(1)
OAArteaga, J.E., Rivera-Becerril, E., Le Borgne, S. and 1 more (...) (2024).Influence of furfural on the physiology of Acinetobacter baylyi ADP1. FEMS Microbiology Letters,371
Estrada-Graf, A.A., Sigala, J.-C., Sánchez-Pérez, M. and 1 more (...) (2024).Induction of lipid production through controlled acidification: A transcriptional insight into the metabolism of Scenedesmus obtusiusculus AT-UAM. Process Biochemistry,147175-185| 7 |
OAIslas, F., Sabido, A., Sigala, J.-C. and 1 more (...) (2023).Design of microaerobically inducible miniR1 plasmids. mLife,2(1) 101-104
OAVelazquez, D., Sigala, J.-C., Martínez, L.M. and 3 more (...) (2022).Glucose transport engineering allows mimicking fed-batch performance in batch mode and selection of superior producer strains. Microbial Cell Factories,21(1)
OACastillo-Plata, A.K., Sigala, J.C., Lappe-Oliveras, P. and 1 more (...) (2022).KCL/KOH supplementation improves acetic acid tolerance and ethanol production in a thermotolerant strain of kluyveromyces marxianus isolated from henequen (Agave fourcroydes). Revista Mexicana de Ingeniera Quimica,21(1) | 7 |
Arteaga, J.E., Cerros, K., Rivera-Becerril, E. and 3 more (...) (2021).Furfural biotransformation in Acinetobacter baylyi ADP1 and Acinetobacter schindleri ACE. Biotechnology Letters,43(5) 1043-1050
Juárez, M., González-De La Rosa, C.H., Sigala, J.C. and 1 more (...) (2021).Effect of vitreoscilla hemoglobin on recombinant protein expression and energy and redox state of cho cells. Revista Mexicana de Ingeniera Quimica,20(1) 281-288
Jaén, K.E., Velazquez, D., Sigala, J.-C. and 1 more (...) (2021).Enhancing microaerobic plasmid DNA production by chromosomal expression of Vitreoscilla hemoglobin in E. coli. Biochemical Engineering Journal,166
Velazquez, D., Jaén, K.E., Sigala, J.-C. and 1 more (...) (2021).Minimized backbone and novel microaerobic promoters boost plasmid DNA production. Process Biochemistry,106130-136| 9 |
OAde la Cruz, M., Ramírez, E.A., Sigala, J.-C. and 2 more (...) (2020).Plasmid DNA production in proteome-reduced Escherichia coli. Microorganisms,8(9) 1-8
OALara, A.R., Galindo, J., Jaén, K.E. and 2 more (...) (2020).Physiological response of escherichia coli W3110 and BL21 to the aerobic expression of vitreoscilla hemoglobin. Journal of Microbiology and Biotechnology,30(10) 1592-1596

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26I
BioinformáticaLicenciatura
2
26I
Optativa de Movilidad de Intercambio ILicenciatura
3
26I
Optativa de Movilidad de Intercambio ILicenciatura
4
26I
Optativa de Movilidad de Intercambio ILicenciatura
5
26I
Optativa de Movilidad de Intercambio ILicenciatura
6
26I
Optativa de Movilidad de Intercambio ILicenciatura
7
26I
Optativa de Movilidad de Intercambio ILicenciatura
8
26I
Optativa de Movilidad de Intercambio ILicenciatura
9
26I
Optativa de Movilidad de Intercambio ILicenciatura
10
26I
Optativa de Movilidad de Intercambio ILicenciatura
11
26I
Optativa de Movilidad de Intercambio ILicenciatura
12
26I
Optativa de Movilidad de Intercambio IIILicenciatura
13
26I
Optativa de Movilidad de Intercambio IIILicenciatura
14
26I
Optativa de Movilidad de Intercambio IIILicenciatura
15
26I
Optativa de Movilidad de Intercambio IIILicenciatura
16
26I
Optativa de Movilidad de Intercambio IIILicenciatura
17
26I
Optativa de Movilidad de Intercambio IIILicenciatura
18
26I
Optativa de Movilidad de Intercambio IIILicenciatura
19
26I
Optativa de Movilidad de Intercambio IIILicenciatura
20
26I
Optativa de Movilidad de Intercambio IIILicenciatura
21
26I
Optativa de Movilidad de Intercambio IVLicenciatura
22
26I
Optativa de Movilidad de Intercambio IVLicenciatura
23
26I
Optativa de Movilidad de Intercambio IVLicenciatura
24
26I
Optativa de Movilidad de Intercambio IVLicenciatura
25
26I
Optativa de Movilidad de Intercambio IVLicenciatura
26
26I
Optativa de Movilidad de Intercambio IVLicenciatura
27
26I
Optativa de Movilidad de Intercambio IVLicenciatura
28
26I
Optativa de Movilidad de Intercambio IVLicenciatura
29
26I
Optativa de Movilidad de Intercambio IVLicenciatura
30
26I
Proyecto Terminal IILicenciatura
31
26I
Proyecto Terminal IILicenciatura
32
26I
Proyecto Terminal IILicenciatura
33
26I
Proyecto Terminal IILicenciatura
34
26I
Seminario IPosgrado
35
26I
Seminario IPosgrado
36
25O
Biología MolecularPosgrado
37
25O
Ingeniería Genética y Técnicas MolecularesLicenciatura
38
25O
Proyecto de Investigación Doctoral XIIPosgrado
39
25O
Proyecto Terminal ILicenciatura
40
25O
Proyecto Terminal ILicenciatura
41
25O
Proyecto Terminal ILicenciatura
42
25O
Proyecto Terminal ILicenciatura
43
25O
Proyecto Terminal IILicenciatura
44
25P
Introducción a la Ingeniería BiológicaLicenciatura
45
25P
MicrobiologíaLicenciatura
46
25P
Proyecto de Investigación Doctoral XIPosgrado
47
25P
Proyecto Terminal ILicenciatura
48
25I
BioinformáticaLicenciatura
49
25I
Bioinformática IPosgrado
50
25I
Biología MolecularLicenciatura
51
25I
Proyecto de Investigación Doctoral XPosgrado
52
25I
Seminario Doctoral IVPosgrado
53
24O
Proyecto de Investigación Doctoral IXPosgrado
54
24P
Proyecto de Investigación Doctoral VIIIPosgrado
55
24P
Proyecto Terminal IILicenciatura
56
24P
Proyecto Terminal IILicenciatura
57
24P
Seminario Doctoral IIIPosgrado
58
24P
Seminario Doctoral IVPosgrado
59
24I
Proyecto de Investigación Doctoral VIIPosgrado
60
24I
Proyecto de Investigación Doctoral XPosgrado
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