Academic Work

• ORCID
• Google scholar
• ResearchGate
• Scopus

Sites of interest

• Investigación Médica
• CV

Sustainable Development Goals

Research interests

• Pharmacology of Natural Products
• Research into compounds for the treatment of chronic degenerative diseases
• Molecular pharmacology of plants, extracts, fractions and compounds with antidiabetic, anti-inflammatory and antihypertensive properties

Profile

Dr. Julio Cesar Almanza Pérez is an Experimental Biologist by training and holds a master’s and doctoral degree in Experimental Biology from the Universidad Autónoma Metropolitana, Iztapalapa Campus. He is currently a Full-Time Tenured Professor, Level C, at the Pharmacology Laboratory of the Department of Health Sciences, Division of Biological and Health Sciences. He has been recognized as a Professor with the Desired Profile (Prodep-SEP) and as a National Researcher Level II in Mexico’s National System of Researchers (SNI), under CONACYT.

For the past 15 years, he has conducted cutting-edge research within the Pharmacology research group at UAM, contributing to the advancement of knowledge in the line of research titled: “Pharmacology of medicinal plants and diseases related to metabolic syndrome,” as well as in parallel research lines within the same group. His contributions have been essential to the evolution and maintenance of these research lines, enabling the group to consolidate its position in the areas of Pharmacodynamics and Molecular Pharmacology of natural and synthetic products, focusing on elucidating mechanisms of pharmacological action. Additionally, Dr. Almanza has contributed to the implementation of various pharmacological evaluation models, including in vivo, in situ, in vitro, and in silico approaches. This has established his research group as a benchmark in the study of natural and synthetic resources with therapeutic potential for diseases associated with metabolic syndrome, such as obesity, diabetes, hypertension, and inflammation, both nationally and internationally.

Dr. Almanza has contributed to the publication of 75 research articles and the training of 70 human resources (43 undergraduate, 14 master’s, 9 doctoral, and 4 postdoctoral researchers). He has participated in 218 specialized scientific events (148 national and 70 international). His involvement also includes serving on evaluation committees for research projects, graduate academic commissions, examination and hiring committees, editorial boards, and as a peer reviewer for various indexed international journals. Furthermore, he has been the principal investigator on several research projects funded by institutions such as CONAHCYT, SECTEI, and SEP. He also maintains collaborative ties with researchers from various public health and educational institutions, both nationally and internationally.

Information provided by the academic staff

Research interests

Academic Work

On the following pages you can consult the research work:

• Google scholar

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• ResearchGate

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• Scopus

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• ORCID

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Other sites of interest

Consult the research work on other websites:

• Investigación Médica

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• CV

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Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
OA	De-la-Cruz-Martínez, L., Equihua-González, D., Torres-Chacón, D.L. and 7 more (...) (2026).Targeting Protein Tyrosine Phosphatase 1B (PTP1B) to Improve Insulin Sensitivity Using Indole-Fused Glycyrrhetinic Acid Conjugates with Amino Acids. ACS Medicinal Chemistry Letters,17(3) 679-687	\| 3 \|
OA	Giacoman-Martínez, A., Almanza-Pérez, J.C., Alarcón-Aguilar, F.J. and 6 more (...) (2026).New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies. Canadian Journal of Physiology and Pharmacology,104	\| 3 \|
OA	García-Mejía, C.D., Almanza-Pérez, J.C., Cofas-Vargas, L.F. and 4 more (...) (2026).Triazole-containing xanthone-furanose/pyranose hybrids: synthesis of potential α-glucosidase inhibitors. European Journal of Medicinal Chemistry,302
OA	González-Gallardo, G., Hernández-Vázquez, E., Almanza-Pérez, J.C. and 1 more (...) (2026).Methoxylated 3,4-diaryl-5-methyl-1(H)-pyrazoles: discovery of a new anti-inflammatory scaffold. Bioorganic Chemistry,175	\| 3 \|
OA	López-Sánchez, M., Mendoza-Mota, H., De-la-Cruz-Martínez, L. and 9 more (...) (2026).Optimization of Indole- and Pyrazole-fused Glycyrrhetinic Acid Derivatives as Potent PTP1B Inhibitors: In Silico, In Vitro, In Vivo, and Metabolomic Studies. ACS Bio and Med Chem Au,6(1) 15-35	\| 3 \|
OA	De-la-Cruz-Martínez, L., Martínez-Arellano, R., López-Sánchez, M. and 8 more (...) (2025).Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies. ChemMedChem,20(22)	\| 3 \|
OA	Alarcon-Aguilar, F.J., Rosiles-Alanis, R.W., Blancas-Flores, G. and 6 more (...) (2025).Cucurbita ficifolia regulates the secretomes of adipocytes and macrophages in co-culture, breaking meta-inflammation. Advances in Traditional Medicine,25(3) 709-721	\| 3 \|
OA	Jaimes-Ortega, G.A., Angeles-Floriano, T., Rivera-Torruco, G. and 6 more (...) (2025).Isthmin1 Upregulation in the Intestinal Microenvironment During Salmonella Typhimurium Infection: Identification and Characterization of Isthmin1-Producing Cells. Microorganisms,13(6)
	Arias-Durán, L., Estrada-Soto, S., Gaona-Tovar, E. and 5 more (...) (2025).Preclinical Exploration of 2-Phenyl-1-benzopyran-4-one as a Potential Antihypertensive Agent. Revista Brasileira de Farmacognosia,35(3) 559-566	\| 3 \|
OA	Almanza-Pérez, J.C., Garza, J., González, I. and 2 more (...) (2025).50 years of Chemistry at the Universidad Autónoma Metropolitana. Journal of the Mexican Chemical Society,69(1) i-ii
OA	Juárez-Cruz, S., Estrada-Soto, S., Colín-Lozano, B. and 8 more (...) (2024).Design and Synthesis of Barbiturates and Hydantoins with Multitarget Antidiabetic Effect. Journal of the Mexican Chemical Society,68(4) 609-623	\| 3 \|
OA	Almanza-Pérez, J.C., Garza, J., González, I. and 2 more (...) (2024).50 years of Chemistry at the Universidad Autónoma Metropolitana. Journal of the Mexican Chemical Society,68(4) iv-v
OA	Hurtado-Rios, J.J., Carrasco-Navarro, U., Almanza-Pérez, J.C. and 2 more (...) (2024).Transcriptional Analysis and Identification of a Peptidoglycan Hydrolase (PGH) and a Ribosomal Protein with Antimicrobial Activity Produced by Lactiplantibacillus paraplantarum. International Journal of Molecular Sciences,25(23)
OA	Alarcón-Aguilar, F.J., Almanza-Pérez, J.C., Blancas-Flores, G. and 4 more (...) (2024).Evolution of research in the Pharmacology Laboratory at the Universidad Autónoma Metropolitana-Iztapalapa: A Historical Review. Journal of the Mexican Chemical Society,68(4) 685-716
	Gaona-Tovar, E., Estrada-Soto, S., Ramírez-Hernández, A. and 4 more (...) (2024).Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids. Fitoterapia,179
OA	Méndez-Martínez, M., Zamilpa, A., Zavala-Sánchez, M.A. and 7 more (...) (2024).Anti-adipogenic effect of Malva parviflora on 3T3-L1 adipocytes. PLoS ONE,19(8)
OA	Montoya-Gress, L., Juárez-Rojas, L., Almanza-Pérez, J. and 7 more (...) (2024).Changes in D4 and GABAA subunit α3 receptors in the thalamic reticular nucleus caused by unilateral lesion of the globus pallidus. Acta Neurobiologiae Experimentalis,84(3) 275-287
	Rodríguez-Luévano, A., Almanza-Pérez, J.C., Ortiz-Andrade, R. and 7 more (...) (2024).Discovery of Palindrome Dual PPARγ-GPR40 Agonists for Treating Type 2 Diabetes. ChemMedChem,19(24)	\| 3 \|
OA	Ortiz-Barragán, E., Estrada-Soto, S., Giacoman-Martínez, A. and 7 more (...) (2024).Antihyperglycemic and Hypolipidemic Activities of Flavonoids Isolated from Smilax Dominguensis Mediated by Peroxisome Proliferator-Activated Receptors. Pharmaceuticals,17(11)	\| 3 \|
OA	Chávez-Ortega, M.P., Almanza-Pérez, J.C., Sánchez-Muñoz, F. and 7 more (...) (2024).Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet. Pharmaceuticals,17(2)	\| 3 \|
	Cabello-Arista, B., Melgarejo-Ramírez, Y., Retana-Flores, A. and 9 more (...) (2024).Effects of mesenchymal stem cell culture on radio sterilized human amnion or radio sterilized pig skin in burn wound healing. Cell and Tissue Banking,25(1) 255-267
OA	Castillo-García, E.L., Cossio-Ramírez, A.L., Córdoba-Méndez, Ó.A. and 11 more (...) (2023).In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative Stress Markers in a Metabolic Syndrome Model. Metabolites,13(12)	\| 3 \|
OA	Castro-Martínez, G., Herrera-Ruiz, M., González-Cortázar, M. and 3 more (...) (2023).Effects of Five Coumarins and Standardized Extracts from Tagetes lucida Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone. Pharmaceuticals,16(10)
OA	Estrada-Soto, S., Ornelas-Mendoza, K., Navarrete-Vázquez, G. and 10 more (...) (2023).Insulin Sensitization by PPARγ and GLUT-4 Overexpression/Translocation Mediates the Antidiabetic Effect of Plantago australis †. Pharmaceuticals,16(4)	\| 3 \|
OA	Cruz-Torres, K.C., Estrada-Soto, S., Arias-Durán, L. and 9 more (...) (2023).LC-MS Fingerprinting Development for Standardized Precipitate from Agastache mexicana, Which Induces Antihypertensive Effect through NO Production and Calcium Channel Blockade †. Pharmaceutics,15(9)
	Madrigal-Angulo, J.L., Ménez-Guerrero, C., Estrada-Soto, S. and 8 more (...) (2022).Synthesis, in vitro, in silico and in vivo hypoglycemic and lipid-lowering effects of 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones mediated by dual PPAR α/γ modulation. Bioorganic and Medicinal Chemistry Letters,70	\| 3 \|
	Cortés A, J., Sánchez-Mendoza, E., Zamilpa, A. and 8 more (...) (2022).Steroidal saponin from Agave marmorata Roezl modulates inflammatory response by inhibiting NF-κB and AP-1. Natural Product Research,36(4) 1123-1128	\| 3 \|
	Rosiles-Alanis, W., Zamilpa, A., García-Macedo, R. and 6 more (...) (2022).4-Hydroxybenzoic Acid and β-Sitosterol from Cucurbita ficifolia Act as Insulin Secretagogues, Peroxisome Proliferator-Activated Receptor-Gamma Agonists, and Liver Glycogen Storage Promoters: In Vivo, in Vitro, and in Silico Studies. Journal of Medicinal Food,25(6) 588-596	\| 3 \|
	Gaona-Tovar, E., Estrada-Soto, S., González-Trujano, M.E. and 5 more (...) (2022).Antinociceptive and gastroprotective activities of Bocconia arborea S. Watson and its bioactive metabolite dihydrosanguinarine in murine models. Journal of Ethnopharmacology,296
OA	Gutiérrez-Rojas, R.A., Aguayo-Cerón, K.A., Vargas-De-León, C. and 5 more (...) (2022).Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells. Life,12(11)	\| 3 \|
OA	Colin-Lozano, B., Torres-Gomez, H., Hidalgo-Figueroa, S. and 4 more (...) (2022).Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study. Pharmaceuticals,15(1)	\| 3 \|
OA	Porras-Dávila, S.L., Jiménez-Ferrer, E., Román Ramos, R. and 3 more (...) (2022).Herniarin, Dimethylfraxetin and Extracts from Tagetes lucida, in Psychosis Secondary to Ketamine and Its Interaction with Haloperidol. Plants,11(20)
OA	Hurtado-Rios, J.J., Carrasco-Navarro, U., Almanza-Pérez, J.C. and 1 more (...) (2022).Ribosomes: The New Role of Ribosomal Proteins as Natural Antimicrobials. International Journal of Molecular Sciences,23(16)
OA	Hernández-Díazcouder, A., González-Ramírez, J., Giacoman-Martínez, A. and 10 more (...) (2021).High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma. PeerJ,9
OA	Giacoman-Martínez, A., Alarcón-Aguilar, F.J., Zamilpa, A. and 4 more (...) (2021).α-Amyrin induces glut4 translocation mediated by AMPK and PPARδ/γ in c2c12 myoblasts. Canadian Journal of Physiology and Pharmacology,99(9) 935-942	\| 3 \|
	Hidalgo-Figueroa, S., Rodríguez-Luévano, A., Almanza-Pérez, J.C. and 4 more (...) (2021).Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes. European Journal of Pharmacology,907	\| 3 \|
OA	Mandujano-Lázaro, G., Galaviz-Hernández, C., Reyes-López, C.A. and 5 more (...) (2021).A short S-equol exposure has a long-term inhibitory effect on adipogenesis in mouse 3T3-L1 cells. Applied Sciences (Switzerland),11(20)	\| 3 \|
	Arias-Durán, L., Estrada-Soto, S., Hernández-Morales, M. and 5 more (...) (2021).Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies. Journal of Ethnopharmacology,273	\| 3 \|
	Romero-Nava, R., Alarcón-Aguilar, F.J., Giacoman-Martínez, A. and 7 more (...) (2021).Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes. Inflammation Research,70(5) 605-618	\| 3 \|
	Fortis-Barrera, M.D.L.Á., Alarcón-Aguilar, F.J., Becerril-García, A. and 6 more (...) (2020).Mechanism of the Hypoglycemic Activity and Hepatoprotective Effect of the Aqueous Extract of Cecropia obtusifolia Bertol. Journal of Medicinal Food,23(7) 783-792	\| 3 \|
	Loza-Rodríguez, H., Estrada-Soto, S., Alarcón-Aguilar, F.J. and 5 more (...) (2020).Oleanolic acid induces a dual agonist action on PPARγ/α and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes. European Journal of Pharmacology,883	\| 3 \|
	Giles-Rivas, D., Estrada-Soto, S., Aguilar-Guadarrama, A.B. and 5 more (...) (2020).Antidiabetic effect of Cordia morelosana, chemical and pharmacological studies. Journal of Ethnopharmacology,251	\| 3 \|
	Mora-Ramiro, B., Jiménez-Estrada, M., Zentella-Dehesa, A. and 5 more (...) (2020).Cacalol Acetate, a Sesquiterpene from Psacalium decompositum, Exerts an Anti-inflammatory Effect through LPS/NF-KB Signaling in Raw 264.7 Macrophages. Journal of Natural Products,83(8) 2447-2455	\| 3 \| 9 \|

Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	26I	Método Experimental	Posgrado
2	26I	Principios de Farmacología y Toxicología	Licenciatura
3	26I	Proyecto de Investigación III	Licenciatura
4	26I	Trabajo de Investigación VIII	Posgrado
5	26I	Trabajo de Redacción de Tesis II	Posgrado
6	26I	Farmacología Especial II	Licenciatura
7	25O	Farmacología Especial I	Licenciatura
8	25O	Proyecto de Investigación III	Licenciatura
9	25O	Seminario de Escritura de Tesis III	Posgrado
10	25O	Temas Selectos de Biología Experimental I	Posgrado
11	25O	Temas Selectos de Biología Experimental I	Posgrado
12	25O	Temas Selectos de Biología Experimental I	Posgrado
13	25O	Trabajo de Investigación VII	Posgrado
14	25O	Trabajo de Redacción de Tesis I	Posgrado
15	25O	Trabajo Experimental III	Posgrado
16	25P	Bioestadística Clínica	Posgrado
17	25P	Farmacología Especial I	Licenciatura
18	25P	Principios de Farmacología y Toxicología	Licenciatura
19	25P	Proyecto de Investigación II	Licenciatura
20	25P	Proyecto de Investigación III	Licenciatura
21	25P	Seminario de Avances de Investigación VII	Posgrado
22	25P	Seminario de Escritura de Tesis II	Posgrado
23	25P	Temas Selectos de Biología Experimental II	Posgrado
24	25P	Temas Selectos de Biología Experimental III	Posgrado
25	25P	Trabajo de Investigación IX	Posgrado
26	25P	Trabajo de Investigación VI	Posgrado
27	25P	Trabajo Experimental II	Posgrado
28	25I	Trabajo Experimental I	Posgrado
29	25I	Trabajo de Investigación VIII	Posgrado
30	25I	Trabajo de Investigación V	Posgrado
31	25I	Seminario de Escritura de Tesis I	Posgrado
32	25I	Proyecto de Investigación II	Licenciatura
33	25I	Proyecto de Investigación I	Licenciatura
34	25I	Principios de Farmacología y Toxicología	Licenciatura
35	25I	Farmacología Especial II	Licenciatura
36	25I	Proyecto de Investigación III	Licenciatura
37	24O	Crecimiento Económico I	Licenciatura
38	24O	Farmacología Especial I	Licenciatura
39	24O	Proyecto de Investigación I	Licenciatura
40	24O	Proyecto de Investigación II	Licenciatura
41	24O	Proyecto de Investigación III	Licenciatura
42	24O	Trabajo de Investigación IV	Posgrado
43	24O	Trabajo de Investigación IX	Posgrado
44	24O	Trabajo de Investigación VII	Posgrado
45	24P	Trabajo de Investigación III	Posgrado
46	24P	Trabajo de Investigación VIII	Posgrado
47	24P	Trabajo de Investigación VI	Posgrado
48	24P	Seminario de Escritura de Tesis III	Posgrado
49	24P	Seminario de Avances de Investigación VI	Posgrado
50	24P	Proyecto de Investigación II	Licenciatura
51	24P	Proyecto de Investigación III	Licenciatura
52	24P	Farmacología Especial I	Licenciatura
53	24P	Proyecto de Investigación I	Licenciatura
54	24P	Principios de Farmacología y Toxicología	Licenciatura
55	24I	Seminario de Escritura de Tesis II	Posgrado
56	24I	Trabajo de Investigación II	Posgrado
57	24I	Trabajo de Investigación V	Posgrado
58	24I	Trabajo de Investigación VII	Posgrado
59	24I	Trabajo de Redacción de Tesis III	Posgrado
60	24I	Trabajo de Redacción de Tesis III	Posgrado

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