Academic Work

• ORCID
• Scopus

Sites of interest

• Junta Directiva

Academic Group

• Cell Physiology

Research interests

• Effect of chronic ethanol intake in liver and pancreas
• Effect of lipid overload at cellular level
• Progression of cell damage in response to a second aggression
• Cellular response to cadmium exposure
• Molecular strategies for damage recovery after different aggressions

Profile

Professor María Concepción Gutiérrez Ruiz is a Chemist with a master's degree in Experimental Biology and a Ph.D. in Pharmacology. In 1976, she started working at the Health Sciences Department at the Universidad Autónoma Metropolitana, Unidad Iztapalapa, where she continues working. She has held different academic administrative positions, which stands out being the coordinator of the Master and Ph.D. studies of the Biological and Health Sciences Division.

Her field of knowledge is the study of the mechanism of damage and repair of different cell types, both at the cellular and molecular level, by different aggressors such as ethanol, acetaldehyde, lipid, and cholesterol overload, and heavy metals, among others.

Professor Gutiérrez has research collaborations with national and foreign researchers. She has published 121 research articles and 27 book chapters and has directed 40 theses of postgraduate students. She has been teaching for over 44 years at bachelors and graduate levels. In 2005, she was named Distinguished Professor of the University.

She has been a member of decision-making agencies in various educational, scientific, and technological development institutions: President of the evaluation committee for basic research projects in the area of health sciences of CONACYT, member of the Council for the Promotion and Scientific, Technological, and Innovation Development of the Secretariat of Science, Technology, and Innovation of Mexico City; the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Government Council; member of the commission of evaluation of professors and academic technicians of the Institute of Biomedical Research of UNAM since 2017; and member of the Awards Commission of the Mexican Academy of Sciences in the periods 2010-2012 and 2016-2018. She is currently a member of the UAM Board of Directors.

Information provided by the academic staff

Research interests

Academic Work

On the following pages you can consult the research work:

• Scopus

See publications

• ORCID

See publications

Other sites of interest

Consult the research work on other websites:

• Junta Directiva

See information

Academic Group

Consult the information provided by the Academic Group

• Cell Physiology

See information

Some examples of publications

Select the bibliographic reference to consult each publication:

Open Access	References	UN SDGs
	Gerardo-Ramírez, M., German-Ramirez, N., Escobedo-Calvario, A. and 6 more (...) (2023).The hepatic effects of GDF11 on health and disease. Biochimie,208129-140	\| 3 \|
OA	Torres-Flores, U., Díaz-Espinosa, F., López-Santaella, T. and 10 more (...) (2023).Spermiogenesis alterations in the absence of CTCF revealed by single cell RNA sequencing. Frontiers in Cell and Developmental Biology,11
OA	Pérez-Aguilar, B., Marquardt, J.U., Muñoz-Delgado, E. and 4 more (...) (2023).Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression. Cancers,15(18)	\| 3 \|
	Palestino-Domínguez, M., Escobedo-Calvario, A., Salas-Silva, S. and 7 more (...) (2023).Erk1/2 signaling mediates the HGF-induced protection against ethanol and acetaldehyde-induced toxicity in the pancreatic RINm5F cell line. Journal of Biochemical and Molecular Toxicology,37(4)
OA	Quevedo-Ocampo, J., Escobedo-Calvario, A., Souza-Arroyo, V. and 5 more (...) (2022).Folate Metabolism in Hepatocellular Carcinoma. What Do We Know So Far?. Technology in Cancer Research and Treatment,21	\| 3 \|
	Souza-Arroyo, V., Fabián, J.J., Bucio-Ortiz, L. and 3 more (...) (2022).The mechanism of the cadmium-induced toxicity and cellular response in the liver. Toxicology,480	\| 3 \|
OA	González-González, L., Gallego-Gutiérrez, H., Martin-Tapia, D. and 10 more (...) (2022).ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing. Tissue Barriers,10(2)
OA	Pérez-Pérez, W.D., Carrasco-Navarro, U., García‑Estrada, C. and 4 more (...) (2022).bZIP transcription factors PcYap1 and PcRsmA link oxidative stress response to secondary metabolism and development in Penicillium chrysogenum. Microbial Cell Factories,21(1)
	Salas-Silva, S., López-Ramirez, J., Barrera-Chimal, J. and 9 more (...) (2022).Hepatocyte growth factor reverses cholemic nephropathy associated with α-naphthylisothiocyanate-induced cholestasis in mice. Life Sciences,295
OA	Simoni-Nieves, A., Clavijo-Cornejo, D., Salas-Silva, S. and 6 more (...) (2021).HGF/c-Met regulates p22phox subunit of the NADPH oxidase complex in primary mouse hepatocytes by transcriptional and post-translational mechanisms. Annals of Hepatology,25
OA	Salgado-García, R., Coronel-Hernández, J., Delgado-Waldo, I. and 6 more (...) (2021).Negative regulation of ulk1 by microrna-106a in autophagy induced by a triple drug combination in colorectal cancer cells in vitro. Genes,12(2) 1-14	\| 3 \|
OA	Chávez-Rodríguez, L., Escobedo-Calvario, A., Salas-Silva, S. and 5 more (...) (2021).Fructose Consumption and Hepatocellular Carcinoma Promotion. Livers,1(4) 250-262	\| 3 \|
OA	Simoni-Nieves, A., Salas-Silva, S., Chávez-Rodríguez, L. and 10 more (...) (2021).The consumption of cholesterol-enriched diets conditions the development of a subtype of hcc with high aggressiveness and poor prognosis. Cancers,13(7)	\| 3 \|
OA	Salas-Silva, S., Simoni-Nieves, A., Chávez-Rodríguez, L. and 3 more (...) (2021).Mechanism of cholangiocellular damage and repair during cholestasis. Annals of Hepatology,26	\| 3 \|
	Hernandez, S., Simoni-Nieves, A., Gerardo-Ramírez, M. and 14 more (...) (2021).GDF11 restricts aberrant lipogenesis and changes in mitochondrial structure and function in human hepatocellular carcinoma cells. Journal of Cellular Physiology,236(5) 4076-4090	\| 3 \|
	Salas-Silva, S., Simoni-Nieves, A., Razori, M.V. and 10 more (...) (2020).HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress. Biochemical Pharmacology,174
	Bello-Monroy, O., Mata-Espinosa, D., Enríquez-Cortina, C. and 10 more (...) (2020).Hepatocyte growth factor enhances the clearance of a multidrug-resistant Mycobacterium tuberculosis strain by high doses of conventional chemotherapy, preserving liver function. Journal of Cellular Physiology,235(2) 1637-1648	\| 3 \|
	Yessica Eduviges, Z.-C., Martínez-Nava, G., Reyes-Hinojosa, D. and 18 more (...) (2020).Impact of cadmium toxicity on cartilage loss in a 3D in vitro model. Environmental Toxicology and Pharmacology,74
OA	Simoni-Nieves, A., Gerardo-Ramírez, M., Pedraza-Vázquez, G. and 6 more (...) (2019).GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies. Frontiers in Oncology,9	\| 3 \|
	Domínguez-Pérez, M., Simoni-Nieves, A., Rosales, P. and 10 more (...) (2019).Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis. Journal of Cellular Physiology,234(5) 7213-7223	\| 3 \|
	Salas-Silva, S., Simoni-Nieves, A., Lopez-Ramirez, J. and 4 more (...) (2019).Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies. Life Sciences,218324-339	\| 3 \|
	Fernández-Torres, J., Martínez-Nava, G.A., Zamudio-Cuevas, Y. and 10 more (...) (2019).Impact of the gene-gene interactions related to the HIF-1α signaling pathway with the knee osteoarthritis development. Clinical Rheumatology,38(10) 2897-2907
OA	Gerardo-Ramírez, M., Lazzarini-Lechuga, R., Hernández-Rizo, S. and 9 more (...) (2019).GDF11 exhibits tumor suppressive properties in hepatocellular carcinoma cells by restricting clonal expansion and invasion. Biochimica et Biophysica Acta - Molecular Basis of Disease,1865(6) 1540-1554	\| 3 \|
	Reyes-Hinojosa, D., Lozada-Pérez, C.A., Zamudio Cuevas, Y. and 8 more (...) (2019).Toxicity of cadmium in musculoskeletal diseases. Environmental Toxicology and Pharmacology,72
	Palestino-Dominguez, M., Pelaez-Luna, M., Lazzarini-Lechuga, R. and 8 more (...) (2018).Recombinant human hepatocyte growth factor provides protective effects in cerulein-induced acute pancreatitis in mice. Journal of Cellular Physiology,233(12) 9354-9364
	Simoni-Nieves, A., Clavijo-Cornejo, D., Gutiérrez-Ruiz, M.C. and 1 more (...) (2018).Acetaldehyde Effects on Cellular Redox State. The Liver: Oxidative Stress and Dietary Antioxidants,63-70
OA	López-Reyes, A., Clavijo-Cornejo, D., Fernández-Torres, J. and 11 more (...) (2018).Fast morphological gallbladder changes triggered by a hypercholesterolemic diet. Annals of Hepatology,17(5) 857-863	\| 3 \|
	Ahuactzin-Pérez, M., Tlecuitl-Beristain, S., García-Dávila, J. and 4 more (...) (2018).A novel biodegradation pathway of the endocrine-disruptor di(2-ethyl hexyl) phthalate by Pleurotus ostreatus based on quantum chemical investigation. Ecotoxicology and Environmental Safety,147494-499
	Ahuactzin-Pérez, M., Tlécuitl-Beristain, S., García-Dávila, J. and 4 more (...) (2018).Kinetics and pathway of biodegradation of dibutyl phthalate by Pleurotus ostreatus. Fungal Biology,122(10) 991-997
	Rosales-Cruz, P., Domínguez-Pérez, M., Reyes-Zárate, E. and 8 more (...) (2018).Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation. Toxicology,398-39941-51
OA	Ahuactzin-Pérez, M., Tlecuitl-Beristain, S., García-Dávila, J. and 4 more (...) (2018).Mineralization of high concentrations of the endocrine disruptor dibutyl phthalate by Fusarium culmorum. 3 Biotech,8(1)	\| 15 \|
OA	Enríquez-Cortina, C., Bello-Monroy, O., Rosales-Cruz, P. and 11 more (...) (2017).Cholesterol overload in the liver aggravates oxidative stressmediated DNA damage and accelerates hepatocarcinogenesis. Oncotarget,8(61) 104136-104148	\| 3 \|
	Ramírez-Fernández, O., Godínez, R., Zuñiga-Aguilar, E. and 4 more (...) (2017).Cell cocultures on coated scaffolds applied to liver models. International Journal of Medical Engineering and Informatics,9(4) 332-350
	Gómez-Quiroz, L.E., Gutiérrez-Ruiz, M.C., Marquardt, J.U. and 2 more (...) (2017).Redox Regulation by HGF/c-Met in Liver Disease. Liver Pathophysiology: Therapies and Antioxidants,375-387
OA	Pérez-Tejada, E., Morales-Corona, J., Gómez-Quiróz, L.E. and 2 more (...) (2017).Effect of synthesis variables of plasma synthesized polymers on growth of hepg2 cells. Biocell,41(2-3) 41-43
	Flores, D., Souza, V., Betancourt, M. and 7 more (...) (2017).Oxidative stress as a damage mechanism in porcine cumulus-oocyte complexes exposed to malathion during in vitro maturation. Environmental Toxicology,32(6) 1669-1678
OA	Fernández-Torres, J., Martínez-Nava, G.A., Gutiérrez-Ruíz, M.C. and 2 more (...) (2017).Role of HIF-1α signaling pathway in osteoarthritis: A systematic review. Revista Brasileira de Reumatologia,57(2) 162-173
OA	Fernández‐Torres, J., Martínez‐Nava, G.A., Gutiérrez‐Ruíz, M.C. and 2 more (...) (2017).Role of HIF‐1α signaling pathway in osteoarthritis: a systematic review. Revista Brasileira de Reumatologia,57(2) 162-173
OA	Medina-Luna, D., Santamaría-Olmedo, M.G., Zamudio-Cuevas, Y. and 12 more (...) (2017).Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress. Lipids in Health and Disease,16(1)	\| 3 \|
OA	López-Islas, A., Chagoya-Hazas, V., Pérez-Aguilar, B. and 6 more (...) (2016).Cholesterol enhances the toxic effect of ethanol and acetaldehyde in primary mouse hepatocytes. Oxidative Medicine and Cellular Longevity,2016	\| 3 \|
OA	Nuño-Lámbarri, N., Domínguez-Pérez, M., Baulies-Domenech, A. and 11 more (...) (2016).Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice. Oxidative Medicine and Cellular Longevity,2016
OA	Ramírez-Fernández, O., Zúñiga-Aguilar, E., Gómez-Quiroz, L.E. and 2 more (...) (2016).Organic-polymeric radial flow biorreactor for liver models. Revista Mexicana de Ingenieria Biomedica,37(3) 165-179
OA	Gomez-Quiroz, L.E., Seo, D., Lee, Y.-H. and 9 more (...) (2016).Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress. Toxicology,361-36239-48	\| 3 \|
	Reyes-Zárate, E., Sánchez-Pérez, Y., Gutiérrez-Ruiz, M.C. and 5 more (...) (2016).Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells. Environmental Pollution,214646-656	\| 3 \|
	Ahuactzin-Pérez, M., Tlecuitl-Beristain, S., García-Dávila, J. and 3 more (...) (2016).Degradation of di(2-ethyl hexyl) phthalate by Fusarium culmorum: Kinetics, enzymatic activities and biodegradation pathway based on quantum chemical modelingpathway based on quantum chemical modeling. Science of the Total Environment,566-5671186-1193	\| 15 \|
OA	Domínguez-Pérez, M., Nuño-Lámbarri, N., Clavijo-Cornejo, D. and 8 more (...) (2016).Hepatocyte growth factor reduces free cholesterol-mediated lipotoxicity in primary hepatocytes by countering oxidative stress. Oxidative Medicine and Cellular Longevity,2016
OA	Hernández, I., Domínguez-Pérez, M., Bucio, L. and 5 more (...) (2015).Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model. Food and Chemical Toxicology,76109-115
	López-Reyes, A.G., Martínez-Flores, K., Clavijo-Cornejo, D. and 8 more (...) (2015).Cholesterol accumulation in hepatocytes overactivates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase but abrogates protection response of the hepatocyte growth factor (HGF). Gaceta Medica de Mexico,151(4) 456-464	\| 3 \|
	Ramírez-Fernández, O., Godínez, R., Zuñiga-Aguilar, E. and 4 more (...) (2015).Superficial modification of biopolymeric scaffolds for tridimensional hepatic cell model. International Journal of Medical Engineering and Informatics,7(2) 110-123
	Ramírez-Fernández, O., Godínez, R., Morales, J. and 4 more (...) (2015).Hybrid scaffolds on radial flow bioreactor to generate liver tissue models. IFMBE Proceedings,49148-151
OA	Lozano-Sepulveda, S.A., Bryan-Marrugo, O.L., Cordova-Fletes, C. and 2 more (...) (2015).Oxidative stress modulation in hepatitis C virus infected cells. World Journal of Hepatology,7(29) 2880-2889	\| 3 \|
	Trejo-Vargas, A., Hernández-Mercado, E., Ordóñez-Razo, R.M. and 5 more (...) (2015).Bik subcellular localization in response to oxidative stress induced by chemotherapy, in Two different breast cancer cell lines and a Non-tumorigenic epithelial cell line. Journal of Applied Toxicology,35(11) 1262-1270	\| 3 \|
OA	Pérez-Aguilar, B., Vidal, C.J., Palomec, G. and 5 more (...) (2015).Acetylcholinesterase is associated with a decrease in cell proliferation of hepatocellular carcinoma cells. Biochimica et Biophysica Acta - Molecular Basis of Disease,1852(7) 1380-1387	\| 3 \|
OA	Pineda, C., Fuentes-Gómez, A.J., Hernández-Díaz, C. and 12 more (...) (2015).Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout. Arthritis Research and Therapy,17(1)
OA	Muñoz-Espinosa, L.E., Trujillo-Trujillo, M.E., Martínez-Macías, R.F. and 12 more (...) (2015).Increase of drug use and genotype 3 in HCV-infected patients from Central West and Northeast Mexico. Annals of Hepatology,14(5) 642-651
	Clavijo-Cornejo, D., Gutiérrez-Carrera, M., Palestino-Domínguez, M. and 8 more (...) (2014).Acetaldehyde targets superoxide dismutase 2 in liver cancer cells inducing transient enzyme impairment and a rapid transcriptional recovery. Food and Chemical Toxicology,69102-108	\| 3 \|
OA	Schmulson, M., Pulido-London, D., Rodríguez, Ó. and 5 more (...) (2013).IL-10 and TNF-α polymorphisms in subjects with irritable bowel syndrome in Mexico. Revista Espanola de Enfermedades Digestivas,105(7) 392-399
	Martínez Flores, K., Uribe Marín, B.C., Souza Arroyo, V. and 5 more (...) (2013).Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src. Toxicology in Vitro,27(3) 1031-1042
OA	Enriquez-Cortina, C., Almonte-Becerril, M., Clavijo-Cornejo, D. and 10 more (...) (2013).Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage. Toxicological Sciences,135(1) 26-36	\| 3 \|
OA	Clavijo-Cornejo, D., Enriquez-Cortina, C., López-Reyes, A. and 9 more (...) (2013).Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes. Biochimie,95(6) 1177-1184
	Ramírez-Fernández, O., Godínez, R., Morales, J. and 4 more (...) (2013).Crecimiento volumétrico de hepatocitos en estructuras basadas en biomateriales modificados superficialmente. IFMBE Proceedings,33104-107

Courses offered

*Courses are conducted in spanish

Num.	Trim.	Course Name	Level
1	23O	Temas Selectos de Biología Experimental I	Posgrado
2	23O	Trabajo Experimental I	Posgrado
3	23O	Trabajo de Investigación VIII	Posgrado
4	23O	Seminario de Escritura de Tesis I	Posgrado
5	23P	Trabajo de Investigación VII	Posgrado
6	23P	Trabajo de Investigación IX	Posgrado
7	23I	Trabajo Experimental III	Posgrado
8	23I	Trabajo de Investigación VI	Posgrado
9	23I	Trabajo de Investigación VIII	Posgrado
10	22O	Trabajo Experimental II	Posgrado
11	22O	Trabajo de Investigación V	Posgrado
12	22O	Trabajo de Investigación VII	Posgrado
13	22P	Trabajo Experimental I	Posgrado
14	22P	Trabajo de Investigación IV	Posgrado
15	22P	Trabajo de Investigación VI	Posgrado
16	22P	Seminario de Escritura de Tesis III	Posgrado
17	22I	Introducción a la Investigación II	Licenciatura
18	22I	Trabajo de Investigación III	Posgrado
19	22I	Trabajo de Investigación V	Posgrado
20	22I	Seminario de Escritura de Tesis II	Posgrado
21	21O	Seminario de Escritura de Tesis I	Posgrado
22	21O	Trabajo de Investigación II	Posgrado
23	21O	Trabajo de Investigación IV	Posgrado
24	21P	Introducción a la Investigación II	Licenciatura
25	21P	Temas Selectos de Biología Experimental III	Posgrado
26	21P	Trabajo de Investigación I	Posgrado
27	21P	Trabajo de Investigación III	Posgrado
28	21P	Trabajo de Investigación IX	Posgrado
29	21I	Trabajo de Investigación II	Posgrado
30	21I	Trabajo de Investigación VIII	Posgrado
31	20O	Introducción a la Investigación II	Licenciatura
32	20O	Temas Selectos de Biología Experimental I	Posgrado
33	20O	Temas Selectos de Biología Experimental I	Posgrado
34	20O	Trabajo de Investigación I	Posgrado
35	20O	Trabajo de Investigación VII	Posgrado
36	20P	Introducción a la Investigación II	Licenciatura
37	20P	Proyecto de Investigación III	Licenciatura
38	20P	Temas Selectos de Biología Experimental I	Licenciatura
39	20P	Trabajo Experimental III	Posgrado
40	20P	Trabajo de Investigación VI	Posgrado
41	20P	Trabajo de Investigación IX	Posgrado
42	20I	Proyecto de Investigación II	Licenciatura
43	20I	Trabajo Experimental II	Posgrado
44	20I	Trabajo de Investigación V	Posgrado
45	20I	Trabajo de Investigación VIII	Posgrado

Information provided by the Dirección de Sistemas Escolares

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