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Perfil investigador
Esp
Dr. Alma Elizabeth Cruz Guerrero

Professor
Departament of Biotechnology

Division of Biological and Health Sciences


Level 2
Member of the National System of Researchers
(SNII)

Biology and chemistry



Iztapalapa Campus

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Sustainable Development Goals

• 3 Good Health and Well-being

• 9 Industry, Innovation and Infrastructure


Research interests

• Enzymatic synthesis of oligosaccharides
• Food enzymology
• Milk technology and dairy products
• Probiotics and prebiotics
• Yeast technology

Profile

Doctor Alma Elizabeth Cruz has developed her career as a Professor-Researcher at the Universidad Autónoma Metropolitana (UAM) in the Biotechnology Department of the Iztapalapa Campus.

She studied for a Bachelor's degree in Food Engineering, a Master's degree in Biotechnology, and a Ph.D. in Biotechnology at UAM. She has been a National System of Researchers member since 2007, currently level II, and has been a Professor with a Desirable Profile since 1996.

Professor Cruz participates as responsible and collaborates in different research projects and agreements with the productive sector; she collaborates with national and international institutions in research projects and as co-director of graduate students. The lines of research in which she has worked are related to enzymology applied to food, yeast science, and technology, science and technology of milk and dairy products, probiotics and prebiotics, enzymatic synthesis of oligosaccharides in aqueous and non-aqueous media, nixtamalization technology, presence of aflatoxins in dairy products.

The result of her current scientific production is based on the trajectory of her cooperation with different research groups: Food Biotechnology (UAM Iztapalapa Campus), the research group of the Universidad Autónoma de Hidalgo, with professors from IBT, Universidad Nacional Autónoma de México (UNAM), with researchers from CIAD (Hidalgo) and Colegio de Posgraduados (Chapingo). This trajectory has led her to have a total of 52 publications, including articles and book chapters, one patent, human resources training, 60 social services, 14 research stays, eight undergraduate theses, nine specialization theses, 16 master's and doctoral theses, more than 100 presentations in national and international forums, 13 dissemination articles and multiple participations in project evaluation committees and national and international publications.

She has collaborated in agreements with the productive sector with the following companies: Ácidos Orgánicos, in the biochemical and functional characterization of yeast strains for baking; Unión General de obreros y campesinos de México, projects were carried out for the production of maguey honey, fruit canning and whey; Centro de Control S.A., in advisory services for arbitration on the quality of milk and dairy products; Comercializadora de Lácteos y Derivados S.A., under the project entitled "Increasing the production capacity of fermented milk beverages"; and Centro de Control S.A., under the project entitled "Increasing the production capacity of fermented milk beverages".

Concerning university participation, she was a coordinator of the Food Engineering degree, a member of the Divisional Review Commission, has participated in the commissions for the revision of study plans and programs of the Food Engineering degree, member of the commission of the Biotechnology Graduate Program in two periods, has participated in the commissions for the revision of study plans and programs of the Biotechnology Graduate Program.



Information provided by the academic staff

Research interests

• Enzymatic synthesis of oligosaccharides
• Food enzymology
• Milk technology and dairy products
• Probiotics and prebiotics
• Yeast technology

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAGranados-Martínez, M., Guzmán-Rodríguez, F., Cruz-Guerrero, A. and 1 more (...) (2026).Valorization of requesón Cheese Whey through Synthesis of Galactooligosaccharides with Fungal and Recombinant β-Galactosidases. ACS Food Science and Technology,6(4) 986-9959
OAPavón-Chimal, M.E., Alatorre-Santamaría, S., Guzmán-Rodríguez, F. and 3 more (...) (2026).Optimized of sonication-assisted extraction of α-L-fucosidase from Bifidobacterium spp. for the synthesis of fucosylated oligosaccharides. Revista Mexicana de Ingeniera Quimica,25(3)
OAGarcía-Curiel, L., Pérez-Flores, J.G., Pérez-Escalante, E. and 3 more (...) (2026).Aguamiel as a prebiotic ingredient: Composition, processing, and functional potential for gut microbiota modulation. Zanco Journal of Pure and Applied Sciences,38(4) 52-80
OATorres-Ochoa, C., Jiménez-Pérez, C., Tello-Solís, S.R. and 4 more (...) (2026).Calcium enhances hydrolytic and transfucosylation activities in α-L-fucosidase from Thermotoga maritima through catalytic loop stabilization: an MD simulation study. Applied Microbiology and Biotechnology,110(1)
OAPatlan-Velázquez, L.-F., González-Olivares, L.-G., García-Garibay, M. and 5 more (...) (2026).Bioactive Peptide-Enriched Requeson: A Functional Dairy Product From Whey Fermentation. Food Science and Nutrition,14(4) 12
OAVázquez-Cordero, J.Y., Jaimez-Ordaz, J., Añorve-Morga, J. and 5 more (...) (2026).Aguamiel enriched with whey proteins (WPC-80) as a probiotic vehicle with an inhibitory effect on DPP-IV. Measurement: Food,23
OARobles-Arias, M.A., Jímenez-Pérez, C., Gómez-Castro, C.Z. and 7 more (...) (2026).Effect of temperature on the structure of α-l-fucosidase from Thermotoga maritima: implications from molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics,44(11) 4977-49913
OACarrero-Puentes, S., Jiménez-Pérez, C., Guzmán-Rodríguez, F. and 6 more (...) (2025).Effect of an exopolysaccharide-producing strain of Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772 on the yield and quality of Requeson (Mexican cheese) added with a probiotic. Journal of Dairy Research,92(4) 566-573
Martha-Lucero, N., Cruz-Guerrero, A., Favela-Torres, E. and 3 more (...) (2025).Lactic acid production by direct fermentation of agave fructans. Journal of Chemical Technology and Biotechnology,100(5) 935-9419
OAPatlan-Velazquez, L.F., González-Olivares, L.G., García-Garibay, M. and 4 more (...) (2025).Whey as a substrate for biogenic production of exopolysaccharide. Revista Mexicana de Ingeniera Quimica,24(1)
OAHernández-Martínez, A., Roldán-Hernández, L., Razmkhah, K. and 4 more (...) (2025).Evaluation of aflatoxin M1 binding capacity of kefir exopolysaccharides produced with different fermentation media. International Dairy Journal,169
OARobles-Arias, M., Cruz-Guerrero, A. (2025).Design of an enzymatic process for the obtention of short-chain fructooligosaccharides from Agave salmiana leaves. Food Bioscience,719|12
OARobles-Arias, M., Guzmán-Rodríguez, F., Cruz-Guerrero, A. (2024).Evaluation of the Suitability of Agave salmiana Leaves for Fructooligosaccharydes Recovery. ACS Food Science and Technology,4(7) 1626-1631
OAGuzmán-Rodríguez, F., Gómez-Ruiz, L., Cruz-Guerrero, A. (2024).Antithrombotic and ACE-inhibitory activity of milk fermented by Lacticaseibacillus rhamnosus GG and Lactobacillus delbrueckii ssp. bulgaricus. International Journal of Food Science and Technology,59(12) 9417-9424
OAJiménez-Pérez, C., Roldán-Hernández, L., Cruz-Guerrero, A. and 1 more (...) (2024).Evaluation of the aflatoxin M1 retention capacity in a polysaccharide obtained by fermenting milk with kefir grains. Revista Mexicana de Ingeniera Quimica,23(2) 9
OAGallardo-Martínez, D., Viniegra-González, G., Figueroa-Martínez, F. and 2 more (...) (2024).Isolation and characterization of epiphytic, fructanolytic, homofermentative lactic acid bacteria from Agave salmiana. Revista Mexicana de Ingeniera Quimica,23(1)
OAAlcantar-Morales, S.L., Ramírez-Ortiz, A., Gallardo-Martínez, D. and 3 more (...) (2024).Kinetics and microbiology of pulp silage from decorticated Agave salmiana leaves. Mexican Journal of Biotechnology,9(4) 14-2915
OAHernández-Riveros, E., Olvera-Rosales, L.B., Jaimez-Ordaz, J. and 4 more (...) (2024).Production of an Ice Cream Base with Added Lacticaseibacillus rhamnosus GG and Aguamiel Syrup: Probiotic Viability and Antihypertensive Capacity. Dairy,5(3) 451-463
Patlan-Velázquez, L.-F., González-Olivares, L.-G., García-Garibay, M. and 4 more (...) (2024).Effect of biogenic exopolysaccharides in characteristics and stability of a novel Requeson-type cheese. Food Bioscience,59
OAOlvera-Rosales, L.B., Cruz-Guerrero, A.E., Jaimez-Ordaz, J. and 5 more (...) (2023).Differences in the Proteolytic System of Lactic Acid Bacteria Affect the Release of DPP-IV Inhibitory Peptides from Whey Proteins. Dairy,4(3) 515-526
OAJiménez-Pérez, C., Guzmán-Rodríguez, F., Cruz-Guerrero, A.E. and 1 more (...) (2023).The dual role of fucosidases: tool or target. Biologia,78(7) 1773-17883
OAOlvera-Rosales, L.B., Pérez-Escalante, E., Castañeda-Ovando, A. and 5 more (...) (2023).ACE-Inhibitory Activity of Whey Proteins Fractions Derived of Fermentation by Lacticaseibacillus rhamnosus GG and Streptococcus thermophilus SY-102. Foods,12(12)
OAPavón-Chimal, M.E., Jiménez-Pérez, C., Guzmán-Rodríguez, F. and 6 more (...) (2023).An In silico Analysis of Enzyme-Substrate Interaction in α-L-Fucosidases Belonging to the GH29 Family. Biointerface Research in Applied Chemistry,13(5)
OACastañeda-Ovando, A., Moreno-Vilet, L., Jaimez-Ordaz, J. and 7 more (...) (2023).Aguamiel syrup as a technological diversification product: Composition, bioactivity and present panorama. Future Foods,83
Cruz-Guerrero, A., Gómez-Ruiz, L., Guzmán-RodrÍguez, F. (2023).Xylooligosaccharides (XOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1243-12693
Guzmán-Rodríguez, F., Alatorre-Santamaría, S., Cruz-Guerrero, A. (2023).Human Milk Oligosaccharides (HMOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1383-1411
Alatorre-Santamaría, S., Cruz-Guerrero, A., Guzmán-Rodríguez, F. (2023).Fructooligosaccharides (FOS). Handbook of Food Bioactive Ingredients: Properties and Applications,1271-13003
Martha-Lucero, N., Viniegra-González, G., González-Olivares, L. and 1 more (...) (2023).Biofilm formation by agave epiphytic lactic acid bacteria fed with agave fructans. World Journal of Microbiology and Biotechnology,39(11)
Olvera-Rosales, L.B., Cruz-Guerrero, A.E., García-Garibay, J.M. and 4 more (...) (2023).Bioactive peptides of whey: obtaining, activity, mechanism of action, and further applications. Critical Reviews in Food Science and Nutrition,63(30) 10351-10381
Pavón-Chimal, M.E., Jiménez-Pérez, C., Guzmán-Rodriguez, F. and 6 more (...) (2023).Mechanistic insight into the synthesis of fucooligosaccharides by α-L-fucosidase from Thermotoga maritima belonging to the GH29 family: in silico study. Biologia,78(7) 1825-1832
OACarrero-Puentes, S., Fuenmayor, C., Jiménez-Pérez, C. and 6 more (...) (2022).Development and characterization of an exopolysaccharide-functionalized acid whey cheese (requesón) using Lactobacillus delbrueckii ssp. bulgaricus. Journal of Food Processing and Preservation,46(6)
Pérez-Escalante, E., Alatorre-Santamaría, S., Castañeda-Ovando, A. and 5 more (...) (2022).Human milk oligosaccharides as bioactive compounds in infant formula: recent advances and trends in synthetic methods. Critical Reviews in Food Science and Nutrition,62(1) 181-214
OARobles-Arias, M.A., Guzmán-Rodriguez, F., García-Garibay, M. and 4 more (...) (2021).α-L-fucosidase from Thermotoga maritima: Hydrolytic and transfucosylation activities. Revista Mexicana de Ingeniera Quimica,20(3)
Robles-Arias, M.A., García-Garibay, M., Alatorre-Santamaría, S. and 5 more (...) (2021).Improvement of Fucosylated Oligosaccharides Synthesis by α-L-Fucosidase from Thermotoga maritima in Water-Organic Cosolvent Reaction System. Applied Biochemistry and Biotechnology,193(11) 3553-3569
Jiménez-Pérez, C., Alatorre-Santamaría, S., Tello-Solís, S.R. and 4 more (...) (2021).Analysis of aflatoxin m1 contamination in milk and cheese produced in mexico: A review. World Mycotoxin Journal,14(3) 269-285
Guzmán-Rodríguez, F., Alatorre-Santamaría, S., Gómez-Ruiz, L. and 3 more (...) (2021).Synthesis of fucosylated oligosaccharides with α-l-fucosidase from Thermotoga maritima immobilized on Eupergit® CM. Extremophiles,25(3) 311-317
OAOlvera-Rosales, L.-B., Cruz-Guerrero, A.-E., Ramírez-Moreno, E. and 8 more (...) (2021).Impact of the gut microbiota balance on the health-disease relationship: The importance of consuming probiotics and prebiotics. Foods,10(6) 3
OASebastián-Nicolas, J.L., Contreras-López, E., Ramírez-Godínez, J. and 8 more (...) (2021).Milk fermentation by lacticaseibacillus rhamnosus GG and streptococcus thermophilus SY-102: Proteolytic profile and ACE-inhibitory activity. Fermentation,7(4)
OAde la Vega, M.I.C., Alatorre-Santamaría, S., Gómez-Ruiz, L. and 5 more (...) (2021).Influence of oat β-glucan on the survival and proteolytic activity of lactobacillus rhamnosus gg in milk fermentation: Optimization by response surface. Fermentation,7(4)
OAContreras-López, E., Jaimez-Ordaz, J., Rodríguez-Serrano, G.M. and 4 more (...) (2021).Contenido exopolysaccharide-producing bacteria improves survival and proteolytic profile of lactobacillus rhamnosus gg added to semi-ripened cheese volumen 8, número 3, 2009 / volume 8, number 3, 2009. Revista Mexicana de Ingeniera Quimica,20(3)
Jiménez-Pérez, C., Tello-Solís, S.R., Gómez-Castro, C.Z. and 6 more (...) (2020).Spectroscopic studies and molecular modelling of the aflatoxin M1-bovine α-lactalbumin complex formation. Journal of Photochemistry and Photobiology B: Biology,209
OASebastián-Nicolás, J.L., Cruz-Guerrero, A.E., Castañeda-Ovando, A. and 4 more (...) (2020).Enrichment of lactoferrin by a simple process based on solid phase extraction. Revista Mexicana de Ingeniera Quimica,19(1) 239-2493
Pérez-Escalante, E., Cruz-Guerrero, A.E., Álvarez-Romero, G.A. and 3 more (...) (2020).Urea as the best fibrin solubilizer in the thrombin inhibition analysis: Theoretical and experimental modeling of fibrinogen denaturation. Chemical Physics Letters,748
Sebastián-Nicolás, J.L., González-Olivares, L.G., Vázquez-Rodríguez, G.A. and 3 more (...) (2020).Valorization of whey using a biorefinery. Biofuels, Bioproducts and Biorefining,14(5) 1010-10277

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26P
Trabajo Experimental VIIPosgrado
2
26P
Trabajo Experimental VIIPosgrado
3
26P
Trabajo Experimental VIIPosgrado
4
26P
Trabajo Experimental VPosgrado
5
26P
Trabajo Experimental IPosgrado
6
26I
Trabajo Experimental IVPosgrado
7
26I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
8
26I
Trabajo Experimental IXPosgrado
9
26I
Trabajo Experimental VIPosgrado
10
26I
Trabajo Experimental VIPosgrado
11
26I
Trabajo Experimental VIPosgrado
12
25O
Trabajo Experimental VPosgrado
13
25O
Seminario de Proyecto DoctoralPosgrado
14
25O
Trabajo Experimental VPosgrado
15
25O
Trabajo Experimental VPosgrado
16
25O
Trabajo Experimental VIIIPosgrado
17
25P
Tecnología EnzimáticaLicenciatura
18
25P
Química y Enzimología de AlimentosLicenciatura
19
25P
Seminario de Informe TerminalPosgrado
20
25P
Trabajo Experimental IVPosgrado
21
25P
Trabajo Experimental IVPosgrado
22
25P
Trabajo Experimental VIIPosgrado
23
25I
Seminario de Proyecto DoctoralPosgrado
24
25I
Química y Enzimología de AlimentosLicenciatura
25
25I
Seminario de Informe TerminalPosgrado
26
25I
Seminario de Proyecto DoctoralPosgrado
27
25I
Tecnología EnzimáticaLicenciatura
28
25I
Trabajo Experimental IIIPosgrado
29
25I
Trabajo Experimental VIPosgrado
30
24O
Trabajo Experimental IIPosgrado
31
24O
Química y Enzimología de AlimentosLicenciatura
32
24O
Trabajo Experimental VPosgrado
33
24O
Trabajo Experimental XIIPosgrado
34
24P
Seminario de Informe TerminalPosgrado
35
24P
Química y Bioquímica de AlimentosPosgrado
36
24P
Química y Enzimología de AlimentosLicenciatura
37
24P
Seminario de Informe TerminalPosgrado
38
24P
Seminario de Informe TerminalPosgrado
39
24P
Trabajo Experimental IPosgrado
40
24P
Trabajo Experimental IVPosgrado
41
24P
Trabajo Experimental XIPosgrado
42
24I
Seminario de Proyecto DoctoralPosgrado
43
24I
Trabajo Experimental XIIPosgrado
44
24I
Trabajo Experimental XPosgrado
45
24I
Química y Enzimología de AlimentosLicenciatura
46
24I
Seminario de Revisión Bibliográfica y Proyecto ExperimentalPosgrado
47
24I
Trabajo Experimental IIIPosgrado
48
24I
Trabajo Experimental IIIPosgrado
49
24I
Trabajo Experimental IIIPosgrado
50
24I
Trabajo Experimental XIIPosgrado
51
23O
Trabajo Experimental IIPosgrado
52
23O
Química y Enzimología de AlimentosLicenciatura
53
23O
Tecnología EnzimáticaLicenciatura
54
23O
Tópicos de Biotecnología IIPosgrado
55
23O
Tópicos en Biotecnología IPosgrado
56
23O
Trabajo Experimental IIPosgrado
57
23O
Trabajo Experimental IIPosgrado
58
23O
Trabajo Experimental XIPosgrado
59
23O
Trabajo Experimental XIPosgrado
60
23P
Seminario de Informe TerminalPosgrado
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Universidad Autónoma Metropolitana, 2026.