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Perfil investigador
Esp
Dr. José Miguel Betancourt Rule

Professor
Departament of Health Sciences

Division of Biological and Health Sciences


Emeritus
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Iztapalapa Campus

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Sites of interest

• Personal Web Site

Sustainable Development Goals

• 3 Good Health and Well-Being


Research interests

• In vitro Fertilization in Mammals
• Reproductive Toxicology
• Asisted Experimental Reproduction

Profile

Professor José Miguel Betancourt Rule is a Biologist (1969) with a Master's degree (1971) and Ph.D. (1974) in Biology from the Faculty of Sciences of the Universidad Nacional Autónoma de México (UNAM).He joined the Universidad Autónoma Metropolitana (UAM) in 1974 as a full-time professor in the Department of Health Sciences, where he has worked uninterruptedly.

At UAM, he has held various positions, such as Coordinator of the teaching laboratories, Head of the Research Area in Cellular and Molecular Biology, and Head of the Department of Health Sciences in the division of CBS. He was also the first Coordinator of the Doctorate in Biological Health Sciences. Professor Betancourt has published more than 100 articles in international journals and more than 19 in national journals, with 1726 citations to articles registered in Research Gate and more than 14 chapters in specialized books and textbooks.

He has trained several students, now professors at UAM, who currently have their independent research groups in various fields of knowledge such as: "Malnutrition and analysis with flow cytometry," "Molecular biology and toxicology of gametogenesis," "Andrology," "Gene expression-proteomics" and Professor Betancourt's "Cell biology and fertilization in mammals."

He has received awards such as "Distinguished Professor" from the Academic College of the UAM in 1998. "Merit in Genetics" was awarded by the Mexican Society of Genetics in 1999. "Distinguished Academician" awarded by the Academy of Research in Reproductive Biology in 2011. He is a Mexican Society of Genetics member and the "Academia de Investigación en Biología de la Reproducción AC".

Throughout 50 years of doing scientific research in the field of biology in topics associated with health, the research group to which he belongs contributed initially to the knowledge of the effects of malnutrition at the cellular level, later in the field of assisted reproduction obtaining pigs and sheep by in vitro fertilization, and the impact of gamete cryopreservation. On the other hand, in the field of reproductive toxicology, they have provided information about the damage caused to health by various chemical agents to which we are exposed daily, such as insecticides, herbicides, perfluorinated products, and parabens. The research model used to date is mainly porcine oocytes and spermatozoa (in vitro studies).



Information provided by the academic staff

Research interests

• In vitro Fertilization in Mammals
• Reproductive Toxicology
• Asisted Experimental Reproduction

Academic Work

On the following pages you can consult the research work:



Other sites of interest

Consult the research work on other websites:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OARamírez-Jara, Y., Casado, B., Betancourt, M. and 9 more (...) (2026).Impact of Methylparaben on Cumulus Cell DNA Integrity and Porcine Oocyte Developmental Competence In Vitro. Journal of Applied Toxicology,46(9) 2985-29963
Núñez-Macías, E., Casillas, F., Ramírez-Jara, Y. and 8 more (...) (2026).Effect of Propylparaben on In Vitro Maturation of Porcine Oocytes and Embryo Development. Environmental Toxicology,3
Urrutia-Lopez, C., González-Carranza, L., Barajas-Salinas, A. and 11 more (...) (2026).Prenatal perfluorooctanoic sulfonate exposure is associated with polycystic ovary syndrome-like and related traits in female offspring mice. Molecular and Cellular Endocrinology,613
Barajas-Salinas, A., Bahena, I., Rodríguez-Mercado, J. and 9 more (...) (2025).Exposure of Porcine Oocytes to Methylparaben During In Vitro Maturation Alters the Expression of Genes Involved in Cumulus Cell Expansion and Steroidogenesis, Decreasing Hyaluronic Acid and Progesterone Synthesis. Journal of Applied Toxicology,45(4) 563-575
OABarraza, J., Cleofas, P., Villamil, S. and 14 more (...) (2024).In vitro exposure of porcine spermatozoa to methylparaben, and propylparaben, alone or in combination adversely affects sperm quality. Journal of Applied Toxicology,44(10) 1540-15543
Alcalá-Sánchez, X., Cuapio-Padilla, P., Salazar-López, C. and 8 more (...) (2024).Comparison of DNA damage in granulosa cells of women undergoing controlled ovarian stimulation in in vitro fertilization protocols with the recombinant human follicle-stimulating hormones Corneumon®, Gonal-F®, Pergoveris® and Puregon®: a randomized trial. Archives of Gynecology and Obstetrics,309(5) 2107-2114
OACasillas, F., Flores-González, A., Juárez-Rojas, L. and 6 more (...) (2023).Chronic stress decreases fertility parameters in female rats. Systems Biology in Reproductive Medicine,69(3) 234-244
Solano, F., Hernández, E., Juárez-Rojas, L. and 9 more (...) (2022).Reproductive disruption in adult female and male rats prenatally exposed to mesquite pod extract or daidzein. Reproductive Biology,22(3)
Juárez-Rojas, L., Casillas, F., López, A. and 3 more (...) (2022).Physiological role of reactive oxygen species in testis and epididymal spermatozoa. Andrologia,54(4)
OALópez, A., Betancourt, M., Casas, E. and 3 more (...) (2021).The need for regulation in the practice of human assisted reproduction in Mexico. An overview of the regulations in the rest of the world. Reproductive Health,18(1) 16
OALópez, A., Ducolomb, Y., Casas, E. and 3 more (...) (2021).Effects of Porcine Immature Oocyte Vitrification on Actin Microfilament Distribution and Chromatin Integrity During Early Embryo Development in vitro. Frontiers in Cell and Developmental Biology,9
OACasillas, F., Betancourt, M., Juárez-Rojas, L. and 6 more (...) (2021).Chronic stress detrimentally affects in vivo maturation in rat oocytes and oocyte viability at all phases of the estrous cycle. Animals,11(9)
OALópez, A., Betancourt, M., Ducolomb, Y. and 7 more (...) (2021).DNA damage in cumulus cells generated after the vitrification of in vitro matured porcine oocytes and its impact on fertilization and embryo development. Porcine Health Management,7(1)
Barajas-Salinas, A., Ducolomb, Y., Betancourt, M. and 9 more (...) (2021).Effects of methylparaben on in vitro maturation of porcine oocytes. Journal of Applied Toxicology,41(2) 330-337
Martínez-Quezada, R., González-Castañeda, G., Bahena, I. and 10 more (...) (2021).Effect of perfluorohexane sulfonate on pig oocyte maturation, gap-junctional intercellular communication, mitochondrial membrane potential and DNA damage in cumulus cells in vitro. Toxicology in Vitro,70
Retana-Márquez, S., Juárez-Rojas, L., Ávila-Quintero, A. and 5 more (...) (2020).Neuroendocrine disruption is associated to infertility in chronically stressed female rats. Reproductive Biology,20(4) 474-483
OACasillas, F., Ducolomb, Y., López, A. and 1 more (...) (2020).Effect of porcine immature oocyte vitrification on oocyte-cumulus cell gap junctional intercellular communication. Porcine Health Management,6(1)

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26P
Trabajo de Investigación VIIIPosgrado
2
26P
Análisis de Resultados y Escritura de TesisPosgrado
3
26P
Análisis de Resultados y Escritura de TesisPosgrado
4
26P
Trabajo Experimental IIIPosgrado
5
26P
Trabajo Experimental IIIPosgrado
6
26P
Seminario IIIPosgrado
7
26P
Seminario IIIPosgrado
8
26P
Introducción a la Investigación IILicenciatura
9
26I
Proyecto de Investigación IIILicenciatura
10
26I
Introducción a la Investigación IILicenciatura
11
26I
Seminario IIPosgrado
12
26I
Seminario IIPosgrado
13
26I
Trabajo de Investigación VIIPosgrado
14
26I
Trabajo Experimental IIPosgrado
15
26I
Trabajo Experimental IIPosgrado
16
25O
Seminario IPosgrado
17
25O
Introducción a la Investigación IILicenciatura
18
25O
Proyecto de Investigación IILicenciatura
19
25O
Seminario IPosgrado
20
25O
Seminario VIPosgrado
21
25O
Trabajo de Investigación VIPosgrado
22
25O
Trabajo Experimental IPosgrado
23
25O
Trabajo Experimental IPosgrado
24
25P
Seminario VPosgrado
25
25P
Trabajo de Investigación VPosgrado
26
25I
Trabajo de Investigación IVPosgrado
27
25I
Seminario IVPosgrado
28
24O
Seminario IIIPosgrado
29
24O
Temas Selectos IPosgrado
30
24O
Trabajo de Investigación IIIPosgrado
31
24P
Introducción a la Investigación IILicenciatura
32
24P
Proyecto de Investigación IIILicenciatura
33
24P
Seminario IIPosgrado
34
24P
Trabajo de Investigación IIPosgrado
35
24I
Seminario IPosgrado
36
24I
Introducción a la Investigación IILicenciatura
37
24I
Proyecto de Investigación IILicenciatura
38
24I
Proyecto de Investigación IIILicenciatura
39
24I
Trabajo de Investigación IPosgrado
40
23O
Introducción a la Investigación IILicenciatura
41
23O
Proyecto de Investigación ILicenciatura
42
23O
Proyecto de Investigación IILicenciatura
43
23P
Introducción a la Investigación IILicenciatura
44
23P
Proyecto de Investigación ILicenciatura
45
23I
Trabajo Experimental IIIPosgrado
46
23I
Análisis de Resultados y Escritura de TesisPosgrado
47
23I
Seminario IIIPosgrado
48
22O
Introducción a la Investigación IILicenciatura
49
22O
Seminario IPosgrado
50
22O
Seminario IIPosgrado
51
22O
Trabajo de Investigación VIIPosgrado
52
22O
Trabajo Experimental IPosgrado
53
22O
Trabajo Experimental IIPosgrado
54
22P
Seminario IPosgrado
55
22P
Análisis de Resultados y Escritura de TesisPosgrado
56
22P
Trabajo Experimental IIIPosgrado
57
22P
Trabajo Experimental IPosgrado
58
22P
Trabajo de Investigación VIPosgrado
59
22P
Temas Selectos de Biología de la Reproducción IPosgrado
60
22P
Seminario IIIPosgrado
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Universidad Autónoma Metropolitana, 2026.