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Perfil investigador
Esp
Dr. Marisol López López

Professor
Departament of Biological Systems

Division of Biological and Health Sciences


Emeritus
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Xochimilco Campus

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Research interests

• Pharmacogenomics
• Molecular human genetics
• Molecular genetics of neurological disorders
• Population genetics

Profile

Professor Marisol López López is a Biology Pharmaceutical Chemist who graduated from the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM) with an Honorable Mention; later, she carried out postgraduate studies: Master's in Science (Molecular Biology) at the UNAM Faculty of Sciences, where she obtained the Gabino Barreda Medal and received a Doctorate in Biomedical Sciences (Biochemistry) at the UNAM Faculty of Medicine.

Professor López has published 90 scientific articles (with 1454 citations), 11 popular articles, 25 book chapters, and four collective textbooks. Her first investigations were in molecular biology of plasmids in bacteria of clinical importance, followed by studies related to disorders of human sexual differentiation that impacted knowledge of molecular genetics and cytogenetics, providing relevant information in an era where knowledge of these disorders was limited and contributing with 24 scientific articles in this area.

Subsequently, she conducted significant research in the field of neurological disease genetics providing 24 scientific articles on Alzheimer's disease, Parkinson's disease, Huntington's disease, von Hippel-Lindau disease, prion diseases, cerebral vascular event, epilepsy, ectodermal dysplasia, and Niemann-Pick disease among other disorders. This research and publications on neurogenetics led her to establish a research agreement with the National Institute of Neurology and Neurosurgery Manuel Velasco Suárez (INNNMVS) signed on May 28, 2002 and effective to date without interruptions, with more than 20 research projects approved by the INNNMVS, and having won 8 awards at the Institute's Annual Research Meeting.

She is a pioneer in Mexico and one of the leading national and international researchers in pharmacogenomics and personalized medicine. In 2005, she published the original article "CYP2D6 genotype and phenotype determination in a Mexican Mestizo population," where for the first time, the frequency of slow and ultra-fast metabolizing in Mexican mestizo individuals for the metabolizing enzyme of CYP2D6 drugs of significant clinical relevance was determined. Since then, she has carried out studies on the genetic structure of the Mexican mestizo population and various ethnic populations of Mexico, contributing to the knowledge of the diversity and inter-individual variability of the Mexican population associated with response, metabolism, and adverse reactions to drugs. In addition to contributing to personalized medicine in Mexican patients with neurological and psychiatric diseases, another of her main investigations was published in the journal of Molecular Psychiatry-Nature (impact factor 11.973) with the name of "CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients", demonstrating that patients with major depression with ultrametabolizing phenotype for CYP2D6 are associated with a low adherence to treatment, this information contributes to improve clinical practice in patients under psychiatric treatment.

Professor López is a member of the Iberoamerican Network of Pharmacogenetics and Pharmacogenomics (SIFF-RIBEF; www.ribef.com) and of the CEIBA Consortium for the pharmacogenetic study of Iberoamerican populations, being responsible for the group in Mexico. To date, ten international scientific articles have been published in this consortium. She is also an honorary member of the Mexican Association of Human Genetics, A.C. and the Mexican Academy of Sciences.



Information provided by the academic staff

Research interests

• Pharmacogenomics
• Molecular human genetics
• Molecular genetics of neurological disorders
• Population genetics

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAMuñiz-Hernández, S., Velázquez-Fernández, J.B., Díaz-Chávez, J. and 5 more (...) (2025).Correction: STRA6 polymorphisms are associated with EGFR mutations in locally-advanced and metastatic non-small cell lung cancer patients (Frontiers in Oncology, (2020), 10, (579561), 10.3389/fonc.2020.579561). Frontiers in Oncology,15| 3 |
OAMonroy-Jaramillo, N., Ortega-Vázquez, A., López-López, M. and 1 more (...) (2025).Genetic Variants in Cytokines IL-10 and IL-17A Are Associated with the Risk and Severity of Sporadic Parkinson’s Disease in Mexican Patients. Life,15(9)
OASánchez-Badajos, S., Ortega-Vázquez, A., López-López, M. and 1 more (...) (2025).Valproic Acid and Lamotrigine Differentially Modulate the Telomere Length in Epilepsy Patients. Journal of Clinical Medicine,14(1)
OAZúñiga-Santamaría, T., Pérez-Aldana, B.E., Fricke-Galindo, I. and 6 more (...) (2025).Variants in Neurotransmitter-Related Genes Are Associated with Alzheimer’s Disease Risk and Cognitive Functioning but Not Short-Term Treatment Response. Neurology International,17(5)
OAChavaro-Francisco, G., Hernández-Zavala, A., Bravo-Cidro, C.E. and 10 more (...) (2024).Gene Variants in Components of the microRNA Processing Pathway in Chronic Myeloid Leukemia. Genes,15(8) | 3 |
OAChávez-Arreola, O.I., Lazalde, B., López-López, M. and 2 more (...) (2024).Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes. Frontiers in Pharmacology,15| 3 |
Sosa-Macías, M., Fricke-Galindo, I., Fariñas, H. and 16 more (...) (2023).Pharmacogenetics: ethnicity, treatment and health in Latin American populations. Pharmacogenomics,24(9) 489-492
OAMayén-Lobo, Y.G., Alcaraz-Zubeldia, M., Dávila-Ortiz de Montellano, D.J. and 8 more (...) (2023).Influence of glutathione-related genetic variants on the oxidative stress profile of Mexican patients with psychotic disorders. Brazilian Journal of Psychiatry,45(2) 117-126
OAOrtega-Vázquez, A., Sánchez-Badajos, S., Ramírez-García, M.Á. and 4 more (...) (2023).Longitudinal Changes in Mitochondrial DNA Copy Number and Telomere Length in Patients with Parkinson’s Disease. Genes,14(10)
OAZúñiga Santamaría, T., Yescas Gómez, P., Fricke Galindo, I. and 3 more (...) (2022).Pharmacogenetic studies in Alzheimer disease. Neurologia,37(4) 287-303
Monroy-Jaramillo, N., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 3 more (...) (2022).The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics,23(6) 371-392
Gutiérrez-Santana, J.C., Gerónimo-Gallegos, A., Martínez-Corona, M.B. and 4 more (...) (2022).High Rates of Extensively Drug-Resistant Pseudomonas aeruginosa in Children with Cystic Fibrosis. Current Microbiology,79(11) | 3 |
Fricke-Galindo, I., Pérez-Aldana, B.E., Macías-Kauffer, L.R. and 6 more (...) (2022).Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia. Archives of Medical Research,53(4) 388-398
OAPérez-Aldana, B.E., Martínez-Magaña, J.J., Mayén-Lobo, Y.G. and 12 more (...) (2022).Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers in Psychiatry,13
OAMayén-Lobo, Y.G., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 7 more (...) (2021).Integrative genomic–epigenomic analysis of clozapine-treated patients with refractory psychosis. Pharmaceuticals,14(2) 1-16
Fricke-Galindo, I., Jung-Cook, H., Martínez-Juárez, I.E. and 7 more (...) (2021).Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital. Pharmacogenomics,22(15) 983-996
OAMartínez-Ibarra, A., Martínez-Razo, L.D., MacDonald-Ramos, K. and 5 more (...) (2021).Multisystemic alterations in humans induced by bisphenol A and phthalates: Experimental, epidemiological and clinical studies reveal the need to change health policies. Environmental Pollution,271| 3 |
Ortega-Vázquez, A., Mayen-Lobo, Y.G., Dávila-Ortiz de Montellano, D.J. and 5 more (...) (2021).Alcohol intake potentiates clozapine adverse effects associated to CYP1A2*1C in patients with refractory psychosis. Drug Development Research,82(5) 685-694
OARodrigues-Soares, F., Peñas-Lledó, E.M., Tarazona-Santos, E. and 43 more (...) (2020).Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans. Clinical Pharmacology and Therapeutics,107(1) 257-268
OAGarcía-Delgado, C., Noriega-Juárez, M., Cervantes, A. and 13 more (...) (2020).High penetrance of EDA pathogenic variants in Mexican female carriers with hypohidrotic ectodermal dysplasia. Dermatologica Sinica,38(3) 172-175
Ortega-Vázquez, A., Fricke-Galindo, I., Dorado, P. and 7 more (...) (2020).Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy. Pharmacogenomics Journal,20(6) 845-856
Dávila-Ortiz de Montellano, D.J., González-del Rincón, M.D.L., Monroy-Jaramillo, N. and 6 more (...) (2020).First report of pathogenic SGCE variants in Mexican patients with myoclonus dystonia: A five-year follow-up study. Parkinsonism and Related Disorders,79117-120
OAMuñiz-Hernández, S., Velázquez-Fernández, J.B., Díaz-Chávez, J. and 5 more (...) (2020).STRA6 Polymorphisms Are Associated With EGFR Mutations in Locally-Advanced and Metastatic Non-Small Cell Lung Cancer Patients. Frontiers in Oncology,10| 3 |
Gutiérrez-Santana, J.C., Toscano-Garibay, J.D., López-López, M. and 1 more (...) (2020).Aptamers coupled to nanoparticles in the diagnosis and treatment of microbial infections. Enfermedades Infecciosas y Microbiologia Clinica,38(7) 331-337

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Courses taught by the professor in recent trimesters

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
26I
Proyecto de Investigación IIPosgrado
2
26I
Proyecto de Investigación IIPosgrado
3
26I
Trabajo de Investigación VIIIPosgrado
4
26I
Trabajo de Investigación VIIIPosgrado
5
26I
Trabajo de Investigación IPosgrado
6
26I
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
7
26I
Seminario de Investigación IPosgrado
8
26I
Seminario de Avances de Investigación IPosgrado
9
26I
Proyecto de Investigación IIPosgrado
10
26I
Proyecto de Investigación IIPosgrado
11
25O
Planeación y Diseño de la Investigación en Ciencias FarmacéuticasPosgrado
12
25O
Proyecto de Investigación IPosgrado
13
25O
Proyecto de Investigación IPosgrado
14
25O
Trabajo de Investigación VIIPosgrado
15
25O
Trabajo de Investigación VIIPosgrado
16
25P
Proyecto de Investigación IIIPosgrado
17
25P
Trabajo de Investigación VIPosgrado
18
25P
Trabajo de Investigación VIPosgrado
19
25P
Seminario VIPosgrado
20
25P
Seminario VIPosgrado
21
25P
Seminario de Investigación IIPosgrado
22
25P
Seminario de Investigación IIPosgrado
23
25I
Proyecto de Investigación IIPosgrado
24
25I
Seminario de Investigación IPosgrado
25
25I
Seminario de Investigación IPosgrado
26
25I
Seminario VPosgrado
27
25I
Seminario VPosgrado
28
25I
Trabajo de Investigación VPosgrado
29
25I
Trabajo de Investigación VPosgrado
30
24O
Planeación y Diseño de la Investigación en Ciencias FarmacéuticasPosgrado
31
24O
Trabajo de Investigación IVPosgrado
32
24O
Proyecto de Investigación IPosgrado
33
24O
Seminario IVPosgrado
34
24P
Seminario IIIPosgrado
35
24P
Seminario IIIPosgrado
36
24P
Trabajo de Investigación IIIPosgrado
37
24P
Trabajo de Investigación IIIPosgrado
38
24I
Seminario IIPosgrado
39
24I
Seminario IIPosgrado
40
24I
Trabajo de Investigación IIPosgrado
41
24I
Trabajo de Investigación IIPosgrado
42
23O
Temas Selectos de Farmacia Clínica y Servicios FarmacéuticosPosgrado
43
23O
Trabajo de Investigación IPosgrado
44
23O
Trabajo de Investigación IPosgrado
45
23O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
46
23O
Seminario IPosgrado
47
23O
Seminario IPosgrado
48
23P
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
49
23P
Trabajo de Redacción de Tesis IIIPosgrado
50
23I
Trabajo de Redacción de Tesis IIPosgrado
51
22O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
52
22O
Trabajo de Redacción de Tesis IPosgrado
53
22P
Seminario VIIPosgrado
54
22P
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
55
22P
Trabajo de Investigación IXPosgrado
56
22P
Trabajo de Redacción de Tesis IIIPosgrado
57
22I
Trabajo de Investigación VIIIPosgrado
58
22I
Trabajo de Redacción de Tesis IIPosgrado
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