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Perfil investigador
Esp
Dr. Marisol López López

Professor
Departament of Biological Systems

Division of Biological and Health Sciences


Emeritus
Member of the National System of Researchers
(SNII)

Medicine and Health Sciences



Xochimilco Campus

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Research interests

• Pharmacogenomics
• Molecular human genetics
• Molecular genetics of neurological disorders
• Population genetics

Profile

Professor Marisol López López is a Biology Pharmaceutical Chemist who graduated from the Faculty of Chemistry of the Universidad Nacional Autónoma de México (UNAM) with an Honorable Mention; later, she carried out postgraduate studies: Master's in Science (Molecular Biology) at the UNAM Faculty of Sciences, where she obtained the Gabino Barreda Medal and received a Doctorate in Biomedical Sciences (Biochemistry) at the UNAM Faculty of Medicine.

Professor López has published 90 scientific articles (with 1454 citations), 11 popular articles, 25 book chapters, and four collective textbooks. Her first investigations were in molecular biology of plasmids in bacteria of clinical importance, followed by studies related to disorders of human sexual differentiation that impacted knowledge of molecular genetics and cytogenetics, providing relevant information in an era where knowledge of these disorders was limited and contributing with 24 scientific articles in this area.

Subsequently, she conducted significant research in the field of neurological disease genetics providing 24 scientific articles on Alzheimer's disease, Parkinson's disease, Huntington's disease, von Hippel-Lindau disease, prion diseases, cerebral vascular event, epilepsy, ectodermal dysplasia, and Niemann-Pick disease among other disorders. This research and publications on neurogenetics led her to establish a research agreement with the National Institute of Neurology and Neurosurgery Manuel Velasco Suárez (INNNMVS) signed on May 28, 2002 and effective to date without interruptions, with more than 20 research projects approved by the INNNMVS, and having won 8 awards at the Institute's Annual Research Meeting.

She is a pioneer in Mexico and one of the leading national and international researchers in pharmacogenomics and personalized medicine. In 2005, she published the original article "CYP2D6 genotype and phenotype determination in a Mexican Mestizo population," where for the first time, the frequency of slow and ultra-fast metabolizing in Mexican mestizo individuals for the metabolizing enzyme of CYP2D6 drugs of significant clinical relevance was determined. Since then, she has carried out studies on the genetic structure of the Mexican mestizo population and various ethnic populations of Mexico, contributing to the knowledge of the diversity and inter-individual variability of the Mexican population associated with response, metabolism, and adverse reactions to drugs. In addition to contributing to personalized medicine in Mexican patients with neurological and psychiatric diseases, another of her main investigations was published in the journal of Molecular Psychiatry-Nature (impact factor 11.973) with the name of "CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients", demonstrating that patients with major depression with ultrametabolizing phenotype for CYP2D6 are associated with a low adherence to treatment, this information contributes to improve clinical practice in patients under psychiatric treatment.

Professor López is a member of the Iberoamerican Network of Pharmacogenetics and Pharmacogenomics (SIFF-RIBEF; www.ribef.com) and of the CEIBA Consortium for the pharmacogenetic study of Iberoamerican populations, being responsible for the group in Mexico. To date, ten international scientific articles have been published in this consortium. She is also an honorary member of the Mexican Association of Human Genetics, A.C. and the Mexican Academy of Sciences.



Information provided by the academic staff

Research interests

• Pharmacogenomics
• Molecular human genetics
• Molecular genetics of neurological disorders
• Population genetics

Academic Work

On the following pages you can consult the research work:






Some examples of publications

Select the bibliographic reference to consult each publication:


Open Access References UN SDGs
OAOrtega-Vázquez, A., Sánchez-Badajos, S., Ramírez-García, M.Á. and 4 more (...) (2023).Longitudinal Changes in Mitochondrial DNA Copy Number and Telomere Length in Patients with Parkinson’s Disease. Genes,14(10)
OAMayén-Lobo, Y.G., Alcaraz-Zubeldia, M., Dávila-Ortiz de Montellano, D.J. and 8 more (...) (2023).Influence of glutathione-related genetic variants on the oxidative stress profile of Mexican patients with psychotic disorders. Brazilian Journal of Psychiatry,45(2) 117-126
Sosa-Macías, M., Fricke-Galindo, I., Fariñas, H. and 16 more (...) (2023).Pharmacogenetics: ethnicity, treatment and health in Latin American populations. Pharmacogenomics,24(9) 489-492
Monroy-Jaramillo, N., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 3 more (...) (2022).The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics,23(6) 371-392
OAZúñiga Santamaría, T., Yescas Gómez, P., Fricke Galindo, I. and 3 more (...) (2022).Pharmacogenetic studies in Alzheimer disease. Neurologia,37(4) 287-303
Gutiérrez-Santana, J.C., Gerónimo-Gallegos, A., Martínez-Corona, M.B. and 4 more (...) (2022).High Rates of Extensively Drug-Resistant Pseudomonas aeruginosa in Children with Cystic Fibrosis. Current Microbiology,79(11) | 3 |
Fricke-Galindo, I., Pérez-Aldana, B.E., Macías-Kauffer, L.R. and 6 more (...) (2022).Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia. Archives of Medical Research,53(4) 388-398
OAPérez-Aldana, B.E., Martínez-Magaña, J.J., Mayén-Lobo, Y.G. and 12 more (...) (2022).Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers in Psychiatry,13
Ortega-Vázquez, A., Mayen-Lobo, Y.G., Dávila-Ortiz de Montellano, D.J. and 5 more (...) (2021).Alcohol intake potentiates clozapine adverse effects associated to CYP1A2*1C in patients with refractory psychosis. Drug Development Research,82(5) 685-694
OAMayén-Lobo, Y.G., Martínez-Magaña, J.J., Pérez-Aldana, B.E. and 7 more (...) (2021).Integrative genomic–epigenomic analysis of clozapine-treated patients with refractory psychosis. Pharmaceuticals,14(2) 1-16
Fricke-Galindo, I., Jung-Cook, H., Martínez-Juárez, I.E. and 7 more (...) (2021).Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital. Pharmacogenomics,22(15) 983-996
OAMartínez-Ibarra, A., Martínez-Razo, L.D., MacDonald-Ramos, K. and 5 more (...) (2021).Multisystemic alterations in humans induced by bisphenol A and phthalates: Experimental, epidemiological and clinical studies reveal the need to change health policies. Environmental Pollution,271| 3 |
Ortega-Vázquez, A., Fricke-Galindo, I., Dorado, P. and 7 more (...) (2020).Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy. Pharmacogenomics Journal,20(6) 845-856
Dávila-Ortiz de Montellano, D.J., González-del Rincón, M.D.L., Monroy-Jaramillo, N. and 6 more (...) (2020).First report of pathogenic SGCE variants in Mexican patients with myoclonus dystonia: A five-year follow-up study. Parkinsonism and Related Disorders,79117-120
Gutiérrez-Santana, J.C., Toscano-Garibay, J.D., López-López, M. and 1 more (...) (2020).Aptamers coupled to nanoparticles in the diagnosis and treatment of microbial infections. Enfermedades Infecciosas y Microbiologia Clinica,38(7) 331-337
OARodrigues-Soares, F., Peñas-Lledó, E.M., Tarazona-Santos, E. and 43 more (...) (2020).Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans. Clinical Pharmacology and Therapeutics,107(1) 257-268
OAMuñiz-Hernández, S., Velázquez-Fernández, J.B., Díaz-Chávez, J. and 5 more (...) (2020).STRA6 Polymorphisms Are Associated With EGFR Mutations in Locally-Advanced and Metastatic Non-Small Cell Lung Cancer Patients. Frontiers in Oncology,10| 3 |
OAGarcía-Delgado, C., Noriega-Juárez, M., Cervantes, A. and 13 more (...) (2020).High penetrance of EDA pathogenic variants in Mexican female carriers with hypohidrotic ectodermal dysplasia. Dermatologica Sinica,38(3) 172-175
OAMartínez-Ibarra, A., Martínez-Razo, L.D., Vázquez-Martínez, E.R. and 7 more (...) (2019).Unhealthy levels of phthalates and bisphenol a in mexican pregnant women with gestational diabetes and its association to altered expression of miRNAs involved with metabolic disease. International Journal of Molecular Sciences,20(13) | 3 |
OAFricke-Galindo, I., Jung-Cook, H., LLerena, A. and 1 more (...) (2018).Pharmacogenetics of adverse reactions to antiepileptic drugs. Neurologia,33(3) 165-176
Naranjo, M.-E.G., Rodrigues-Soares, F., Peñas-Lledó, E.M. and 43 more (...) (2018).Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 ibero-and native Americans: RIBEF-CEIBA consortium report on population pharmacogenomics. OMICS A Journal of Integrative Biology,22(9) 575-588
Fricke-Galindo, I., LLerena, A., Jung-Cook, H. and 1 more (...) (2018).Carbamazepine adverse drug reactions. Expert Review of Clinical Pharmacology,11(7) 705-718
Favela-Mendoza, A.F., Rangel-Villalobos, H., Fricke-Galindo, I. and 3 more (...) (2018).Genetic variability among Mexican Mestizo and Amerindian populations based on three ABCB1 polymorphisms. Molecular Biology Reports,45(6) 2525-2533
OAFricke-Galindo, I., Llerena, A., López-López, M. (2017).An update on HLA alleles associated with adverse drug reactions. Drug Metabolism and Personalized Therapy,32(2) 73-87
Monroy-Jaramillo, N., Abad-Flores, J.D., García-Delgado, C. and 12 more (...) (2017).Mutational spectrum of EDA and EDAR genes in a cohort of Mexican mestizo patients with hypohidrotic ectodermal dysplasia. Journal of the European Academy of Dermatology and Venereology,31(7) e321-e324
OAFricke-Galindo, I., Jung-Cook, H., Llerena, A. and 1 more (...) (2016).Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: A report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics). Drug Metabolism and Personalized Therapy,31(2) 61-81
Sesar, A., Cacheiro, P., López-López, M. and 11 more (...) (2016).Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico. Journal of the Neurological Sciences,362321-325
OACéspedes-Garro, C., Rodrigues-Soares, F., Jiménez-Arce, G. and 41 more (...) (2016).Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population. Revista de Biologia Tropical,64(3) 1067-1076
Fricke-Galindo, I., Ortega-Vázquez, A., Monroy-Jaramillo, N. and 5 more (...) (2016).Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers. Pharmacogenomics,17(17) 1913-1930
OAOrtega-Vázquez, A., Dorado, P., Fricke-Galindo, I. and 7 more (...) (2016).CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. Pharmacogenomics Journal,16(3) 286-292
OAFricke-Galindo, I., Céspedes-Garro, C., Rodrigues-Soares, F. and 6 more (...) (2016).Interethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations. Pharmacogenomics Journal,16(2) 113-123
Sosa-Macías, M., Teran, E., Waters, W. and 13 more (...) (2016).Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America. Pharmacogenomics,17(16) 1741-1747
Romo-Gutiérrez, D., Petra-Yescas, López-López, M. and 1 more (...) (2015).Genetic factors of dementia in Parkinson's disease (PD). Gaceta Medica de Mexico,151(1) 110-118
Céspedes-Garro, C., Fricke-Galindo, I., Naranjo, M.E.G. and 6 more (...) (2015).Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes. Expert Opinion on Drug Metabolism and Toxicology,11(12) 1893-1905
Monroy-Jaramillo, N., Guerrero-Camacho, J.L., Rodríguez-Violante, M. and 4 more (...) (2014).Genetic mutations in early-onset Parkinson's disease mexican patients: Molecular testing implications. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics,165(3) 235-244
López-López, M., Peñas-Lledó, E., Dorado, P. and 6 more (...) (2014).CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas. Pharmacogenomics,15(15) 1859-1865
Fricke-Galindo, I., Martínez-Juárez, I.E., Monroy-Jaramillo, N. and 5 more (...) (2014).HLA-A∗02:01:01/-B∗35:01:01/-C∗04:01:01 haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients. Pharmacogenomics,15(15) 1881-1891
De Andrés, F., Sosa-Macías, M., Lazalde-Ramos, B.P. and 44 more (...) (2013).Evaluation of drug-metabolizing enzyme hydroxylation phenotypes in Hispanic populations: The CEIBA cocktail. Drug Metabolism and Drug Interactions,28(3) 135-146
OAKumar, R., Nguyen, E.A., Roth, L.A. and 21 more (...) (2013).Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics (GALA II) study. Journal of Allergy and Clinical Immunology,132(4) 896-e1| 3 |
OAPeñas-Lledó, E.M., Trejo, H.D., Dorado, P. and 6 more (...) (2013).CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients. Molecular Psychiatry,18(1) 8-9
OAGonzález-del Rincón, M.D.L., Monroy Jaramillo, N., Suárez Martínez, A. and 4 more (...) (2013).The L444P GBA mutation is associated with early-onset Parkinson's disease in Mexican Mestizos. Clinical Genetics,84(4) 386-387

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Courses offered

*Courses are conducted in spanish

Num.Trim.Course NameLevel
1
23O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
2
23O
Temas Selectos de Farmacia Clínica y Servicios FarmacéuticosPosgrado
3
23O
Seminario IPosgrado
4
23O
Seminario IPosgrado
5
23O
Trabajo de Investigación IPosgrado
6
23O
Trabajo de Investigación IPosgrado
7
23P
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
8
23P
Trabajo de Redacción de Tesis IIIPosgrado
9
23I
Trabajo de Redacción de Tesis IIPosgrado
10
22O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
11
22O
Trabajo de Redacción de Tesis IPosgrado
12
22P
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
13
22P
Trabajo de Investigación IXPosgrado
14
22P
Trabajo de Redacción de Tesis IIIPosgrado
15
22P
Seminario VIIPosgrado
16
22I
Trabajo de Investigación VIIIPosgrado
17
22I
Trabajo de Redacción de Tesis IIPosgrado
18
21O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
19
21O
Trabajo de Investigación VIIPosgrado
20
21O
Trabajo de Redacción de Tesis IPosgrado
21
21O
Proyecto de Investigación IIIPosgrado
22
21P
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
23
21P
Trabajo de Redacción de Tesis IIIPosgrado
24
21P
Seminario VIIPosgrado
25
21P
Proyecto de Investigación IIPosgrado
26
21P
Seminario VIPosgrado
27
21P
Trabajo de Investigación VIPosgrado
28
21P
Trabajo de Investigación IXPosgrado
29
21I
Proyecto de Investigación IPosgrado
30
21I
Seminario VPosgrado
31
21I
Trabajo de Investigación VPosgrado
32
21I
Trabajo de Investigación VIIIPosgrado
33
21I
Trabajo de Redacción de Tesis IIPosgrado
34
20O
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
35
20O
Trabajo de Investigación IVPosgrado
36
20O
Trabajo de Investigación VIIPosgrado
37
20O
Trabajo de Redacción de Tesis IPosgrado
38
20O
Temas Selectos de Farmacia Clínica y Servicios FarmacéuticosPosgrado
39
20O
Seminario de Investigación IIPosgrado
40
20O
Seminario IVPosgrado
41
20P
Prevención y Control de la Propagación MicrobianaLicenciatura
42
20P
Seminario de Investigación IPosgrado
43
20P
Seminario IIIPosgrado
44
20P
Trabajo de Investigación IIIPosgrado
45
20P
Seminario VIPosgrado
46
20P
Trabajo de Investigación VIPosgrado
47
20P
Trabajo de Investigación IXPosgrado
48
20P
Seminario VIIPosgrado
49
20I
Tecnologías Moleculares para el Diagnóstico y la TerapéuticaLicenciatura
50
20I
Trabajo de Investigación IIPosgrado
51
20I
Seminario VPosgrado
52
20I
Trabajo de Investigación VPosgrado
53
20I
Trabajo de Investigación VIIIPosgrado
54
20I
Planeación y Diseño de la Investigación en Ciencias FarmacéuticasPosgrado
55
20I
Seminario IIPosgrado
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Universidad Autónoma Metropolitana, 2024.